GB2227559A - Biological or chemical test sticks - Google Patents
Biological or chemical test sticks Download PDFInfo
- Publication number
- GB2227559A GB2227559A GB8829356A GB8829356A GB2227559A GB 2227559 A GB2227559 A GB 2227559A GB 8829356 A GB8829356 A GB 8829356A GB 8829356 A GB8829356 A GB 8829356A GB 2227559 A GB2227559 A GB 2227559A
- Authority
- GB
- United Kingdom
- Prior art keywords
- liquid
- core
- layer
- reagent
- permeable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Stick has a core comprising (a) a liquid-permeable core member at one end in longitudinal alignment with (b) a liquid- impermeable core member, and around the core a sleeve comprising (c) a liquid-permeable layer in communication with the liquid-permeable core member and carrying at least one reagent and (d) an outer liquid-impermeable layer through which visible reaction products of said reagent(s) will show.
Description
TEST DEVICE
This invention relates to a device of the type for testing a fluid by formation of visible reaction product due to interaction between the fluid or a species therein and reagent carried by the device.
The invention provides, in one preferred class of embodiment, a biological or chemical test stick of this type having a (preferably substantially eylindrical) sor comprising (a) a liquid-permeable core member (e.g. plug, rod or tube) at one end in longitudinal alignment with [b] a liquid-impermeable ochre member (e.g. plug, rod or tube), and around the core a sleeve comprising [c] a liquid-permeable layer in communication with the liquid-permeable core member and carrying at least one reagent and [d] an outer liquid-impermeable (and e.g. transparent or translucent) layer through which visible reaction product of reagent(s) and test fluid or species therein will show.
In use the end [a] can be inserted into a fluid to be tested, the liquid-permeable core member acting as a wick and transferring liquid to the surrounding liquid-permeable layer [c]; the liquid permeates layer [c] and encounters the reagent(s) carried thereby to give through layer [d) a visible indication of the condition (e.g. pH) of the liquid or of the presence and/or concentration of a targeted species in the liquid.
The liquid-permeable layer (c) may carry one or more diagnostic or other reagents. The or each such reagent will usually be confined to one or more restricted zones of (c3, e.g. to a circumferential ring or rings; where a plurality of reagents is employed, they may be in separate zones, or two or more may be present in the same zone; the or each reagent zone on layer (c] will preferably be over the liquid-impermeable core member (b).
The core and sleeve of a said preferred stick according to the invention will usually be co-terminous, but liquid-permeable core member (a], or this rod or plug (a] and liquid-permeable layer c of the sleeve, might protrude at one end.
The liquid-permeable core member [a] could for example be of gathered creped paper, cotton wool, or filamentary tow; the material might be bonded to itself so as to form a rod or plug or tube which is coherent and dimensionally stable in the absence of a wrapper, it could be pre-formed with its own wrapper (which would of course be such - e.g. of liquid-permeable material and/or perforate etc. - as to permit liquid communication between the interior and surrounding sleeve layer [c)), or could be held in rod or plug form by the said sleeve.
The liquid-impermeable core member tb] could for example be of closed-cell plastics foam. It will usually be inherently dimensionally stable without a wrapper, but as with ta] it could be pre-formed with its own wrapper or held in shape by the said sleeve.
The liquid-permeable layer tc] of the sleeve may for example be of filter paper or chromatography paper. A transparent or translucent sleeve layer td] may for example be of clear plastics film, e.g. of polyester or polyethylene.
Layers [c] and [d] may be pre-laminated before application around the core; layer Ic3 might instead be a coating applied to layer (d] before application of the composite sleeve around the core.
A said preferred test stick according to the invention can be made continuously by continuously forming and advancing longitudinally a core of alternating member [a] and [b], concurrently and continuously longitudinally advancing the sleeve and applying it around the core (e.g. by means of a garniture), and cutting the resulting continuously produced composite stick into finite lengths. In a modification the core is first wrapped in sleeve layer [c], and sleeve layer [d] is subsequently applied (e.g. by wrapping in similar manner or by extrusion) before the composite is cut into finite lengths.
Test sticks according to the invention can be used for a wide variety of diagnostic/chemical/clinical tests, according to the nature of reagent(s) employed with layer [c].
Thus indicators may be used as reagent to provide a stick for pH testing; or the stick may be used for pregnancy testing, layer [c] carrying appropriate antibodies as reagent for interaction with hormones in urine.
Various modifications of the above-described preferred stick are possible. Thus all of the core may be liquid-permeable, though preferably with a portion [b] which is less so than portion [a]; where all of the core is liquid-permeable, a downstream portion preferably has a liquid-impermeable surface or wrap within sleeve [c]. In another variation, liquid-permeable core portion [a] is omitted, so that the test liquid is taken up solely and directly by sleeve layer [c]; in this case the core portion [b] could be permeable or impermeable, though in the former case it preferably has an impermeable skin or wrap. In another variation, the whole of the core is liquid-impermeable; in this case sleeve layer (d] will preferably be perforate or apertured at one end to allow easier access of test liquid to the sleeve layer [c] - this being a feature which could be employed in all described embodiments.
Accordingly, in a broad aspect, the invention provides a biological and/or chemical test stick having a (preferably substantially cylindrical) core and around the core a sleeve comprising [i] a liquid-permeable layer carrying at least one reagent and [ii] an outer liquid-impermeable layer through which visible reaction product of said reagent(s) will show, layer ti] being exposable to contact with a fluid to be tested. The core is usually of circular section.
Claims (2)
1. A biological and/or chemical test stick having a core and around the core a sleeve comprising (i] a liquid-impermeable layer carrying at least one reagent and [ii] an outer liquid-permeable layer through which visible reaction product of said reagent(s) will show, layer [i] being exposable to contact with a fluid to be tested.
2. A biological and/or chemical test stick having a core comprising [aj a liquid-permeable core member at one end in longitudinal alignment with [b] a liquid-impermeable core member, and around the core a sleeve co.mprising [cj a liquid-permeable layer in communication with the liquid-permeable core member and carrying at least one reagent and [d] an outer liquid-impermeable layer through which visible reaction products of said reagent(s) will show.
2. A biological and/or chemical test stick having a core comprising [a] a liquid-permeable core member at one end in longitudinal alignnent with [b] a liquid-impermeable core member, and around the core a sleeve comprising [c] a liquid-permeable layer in communication with the liquid-permeable core member and carrying at least one reagent and [d) an outer liquid-impermeable layer through which visible reaction products of said reagent(s) will show.
Amendments to the claims have been filed as follows 1.A biological and/or chemical test stick having a core and around the core a sleeve ocnnprising [I) a liquid-permeable layer carrying at least one reagent and [ii) an outer liquid-impermeable layer through which visible reaction product of said reagent(s) will show, layer [i] being exposable to contact with a fluid to be tested.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8829356A GB2227559B (en) | 1988-12-16 | 1988-12-16 | Biological or chemical test sticks |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8829356A GB2227559B (en) | 1988-12-16 | 1988-12-16 | Biological or chemical test sticks |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8829356D0 GB8829356D0 (en) | 1989-02-01 |
GB2227559A true GB2227559A (en) | 1990-08-01 |
GB2227559B GB2227559B (en) | 1992-04-01 |
Family
ID=10648592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8829356A Expired - Fee Related GB2227559B (en) | 1988-12-16 | 1988-12-16 | Biological or chemical test sticks |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2227559B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7326383B2 (en) | 2003-12-11 | 2008-02-05 | Taylor Technologies, Inc. | Reagent, apparatus and method for measuring cyanuric acid |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1026451A (en) * | 1961-12-18 | 1966-04-20 | Miles Lab | Improvements in or relating to indicating devices |
-
1988
- 1988-12-16 GB GB8829356A patent/GB2227559B/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1026451A (en) * | 1961-12-18 | 1966-04-20 | Miles Lab | Improvements in or relating to indicating devices |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7326383B2 (en) | 2003-12-11 | 2008-02-05 | Taylor Technologies, Inc. | Reagent, apparatus and method for measuring cyanuric acid |
Also Published As
Publication number | Publication date |
---|---|
GB8829356D0 (en) | 1989-02-01 |
GB2227559B (en) | 1992-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19961216 |