GB2221157B - Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same - Google Patents

Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same

Info

Publication number
GB2221157B
GB2221157B GB8916679A GB8916679A GB2221157B GB 2221157 B GB2221157 B GB 2221157B GB 8916679 A GB8916679 A GB 8916679A GB 8916679 A GB8916679 A GB 8916679A GB 2221157 B GB2221157 B GB 2221157B
Authority
GB
United Kingdom
Prior art keywords
cyclosporin
preparing
same
pharmaceutical composition
intravenous pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8916679A
Other versions
GB8916679D0 (en
GB2221157A (en
Inventor
Erno Orban
Tibor Balogh
Lajos Ila
Gabor Ambrus
Antonia Jekkel
Sandor Elek
Eva Tomori
Lajos Siklosi
Sarudy Eva Toth
Imre Moravcsik
Istvan Elekkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of GB8916679D0 publication Critical patent/GB8916679D0/en
Publication of GB2221157A publication Critical patent/GB2221157A/en
Application granted granted Critical
Publication of GB2221157B publication Critical patent/GB2221157B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
GB8916679A 1988-07-21 1989-07-21 Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same Expired - Lifetime GB2221157B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU883796A HU201567B (en) 1988-07-21 1988-07-21 Process for production of intravenous medical compositions containing cyclosphorin

Publications (3)

Publication Number Publication Date
GB8916679D0 GB8916679D0 (en) 1989-09-06
GB2221157A GB2221157A (en) 1990-01-31
GB2221157B true GB2221157B (en) 1991-12-18

Family

ID=10965544

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8916679A Expired - Lifetime GB2221157B (en) 1988-07-21 1989-07-21 Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same

Country Status (26)

Country Link
US (1) US5047396A (en)
JP (1) JPH07116051B2 (en)
KR (1) KR0137674B1 (en)
AR (1) AR243382A1 (en)
AT (1) AT402258B (en)
AU (1) AU614862B2 (en)
BE (1) BE1004323A4 (en)
CA (1) CA1332712C (en)
CH (1) CH679120A5 (en)
DD (1) DD283934A5 (en)
DE (1) DE3924207A1 (en)
DK (1) DK175540B1 (en)
FI (1) FI92556C (en)
FR (1) FR2635265B1 (en)
GB (1) GB2221157B (en)
GR (1) GR1002184B (en)
HU (1) HU201567B (en)
IL (1) IL91069A (en)
IT (1) IT1231434B (en)
LU (1) LU87560A1 (en)
NL (1) NL194578C (en)
NO (1) NO175287C (en)
NZ (1) NZ230036A (en)
PT (1) PT91246B (en)
SE (1) SE509174C2 (en)
ZA (1) ZA895588B (en)

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US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
GB2251186A (en) * 1990-12-04 1992-07-01 Randall Neal Gatz Polypeptide for use in treatment of autoimmune disease
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
ATE147619T1 (en) 1992-05-13 1997-02-15 Sandoz Ag OPTHALMIC COMPOSITIONS CONTAINING A CYCLOSPORIN
ES2168271T3 (en) 1992-09-25 2002-06-16 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
DE4412201A1 (en) * 1993-04-20 1994-11-10 Rentschler Arzneimittel New pharmaceutical preparations for oral administration containing cyclosporin
CH686761A5 (en) 1993-05-27 1996-06-28 Sandoz Ag Pharmaceutical formulations.
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
DE4340781C3 (en) * 1993-11-30 2000-01-27 Novartis Ag Liquid preparations containing cyclosporin and process for their preparation
KR0146671B1 (en) * 1994-02-25 1998-08-17 김충환 Cyclosporin-containing powder composition
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
WO1997007787A1 (en) * 1995-08-25 1997-03-06 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US20050053594A1 (en) * 1995-11-16 2005-03-10 Dario Alessi RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK
DE19544507B4 (en) * 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
DE29824679U1 (en) 1997-01-30 2002-03-28 Novartis Ag Pharmaceutical compositions
JP4718653B2 (en) * 1997-03-12 2011-07-06 アボツト・ラボラトリーズ Hydrophilic two-component system for administration of cyclosporine
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
AT408186B (en) * 1998-12-15 2001-09-25 Sanochemia Pharmazeutika Ag AQUEOUS PREPARATION OF BETA CAROTINE
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10015814A1 (en) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture
FR2826517B1 (en) * 2001-06-20 2004-03-12 Somfy SUPPLY DEVICE FOR MOTORIZED BLIND OR THE LIKE
AR036852A1 (en) * 2001-10-19 2004-10-06 Isotechnika Inc PRE-CONCENTRATED OF A MICROEMULSION OF CYCLOSPORINE ANALOGS, ITS PREPARATION METHOD AND METHODS TO PRODUCE IMMUNOSUPPRESSION
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
JP4815418B2 (en) * 2007-10-19 2011-11-16 カヤバ工業株式会社 Pneumatic shock absorber
WO2010029374A1 (en) * 2008-09-12 2010-03-18 Critical Pharmaceuticals Limited Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
FR2948568B1 (en) * 2009-07-30 2012-08-24 Sanofi Aventis PHARMACEUTICAL FORMULATION
PT2683406T (en) 2011-03-11 2019-07-08 Beth Israel Deaconess Medical Ct Inc Anti-cd40 antibodies and uses thereof
CN116063481A (en) 2015-09-04 2023-05-05 普里玛托普医疗股份有限公司 Humanized anti-CD 40 antibodies and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3658M (en) * 1964-02-18 1965-11-02 Michel Marie Andre Guerbet Oily composition for intravascular injection.
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
DE2907460A1 (en) * 1978-03-07 1979-09-13 Sandoz Ag NEW RESORBABLE GALENIC COMPOSITIONS
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU534955B2 (en) * 1980-01-23 1984-02-23 Sandoz Ag Cyclosporin a to treat lymphoproliferative disorders
DE3339235A1 (en) * 1983-10-28 1985-05-09 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING POLYURETHANES
DE3339236A1 (en) * 1983-10-28 1985-05-09 Bayer Ag PREPARATION OF MEDICINAL PRODUCTS
EP0336976A4 (en) * 1987-10-02 1990-06-27 Vsesojuznyj Kardiologitsches Pharmaceutical preparation for curing multiple sclerosis and lateral amyotrophic sclerosis.
GB8729153D0 (en) * 1987-12-14 1988-01-27 Efamol Ltd Fatty acid compositions
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
DE3832362A1 (en) * 1988-09-23 1990-03-29 Sandoz Ag NEW CYCLOPEPTOLIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE

Also Published As

Publication number Publication date
AR243382A1 (en) 1993-08-31
KR900001364A (en) 1990-02-27
DE3924207A1 (en) 1990-01-25
BE1004323A4 (en) 1992-11-03
CH679120A5 (en) 1991-12-31
LU87560A1 (en) 1991-02-18
HUT50851A (en) 1990-03-28
FR2635265A1 (en) 1990-02-16
DK362189A (en) 1990-01-22
NO175287B (en) 1994-06-20
IT1231434B (en) 1991-12-04
AU3884589A (en) 1990-02-01
PT91246B (en) 1995-05-04
GB8916679D0 (en) 1989-09-06
FI893520A0 (en) 1989-07-21
DK175540B1 (en) 2004-11-29
ZA895588B (en) 1990-07-25
GR1002184B (en) 1996-03-12
DD283934A5 (en) 1990-10-31
ATA176789A (en) 1996-08-15
DE3924207C2 (en) 1992-07-09
CA1332712C (en) 1994-10-25
JPH03115227A (en) 1991-05-16
SE509174C2 (en) 1998-12-14
KR0137674B1 (en) 1998-05-15
FI92556C (en) 1994-12-12
AT402258B (en) 1997-03-25
NZ230036A (en) 1991-02-26
SE8902588D0 (en) 1989-07-21
JPH07116051B2 (en) 1995-12-13
FI893520A (en) 1990-01-22
DK362189D0 (en) 1989-07-21
NO892995L (en) 1990-01-22
GR890100467A (en) 1990-06-27
FI92556B (en) 1994-08-31
NL8901902A (en) 1990-02-16
NO175287C (en) 1994-09-28
NL194578C (en) 2002-08-05
PT91246A (en) 1990-02-08
US5047396A (en) 1991-09-10
AU614862B2 (en) 1991-09-12
HU201567B (en) 1990-11-28
IL91069A (en) 1993-07-08
IT8921259A0 (en) 1989-07-21
FR2635265B1 (en) 1995-03-17
NO892995D0 (en) 1989-07-21
GB2221157A (en) 1990-01-31
SE8902588L (en) 1990-01-22
NL194578B (en) 2002-04-02

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20090720