GB2220369B - Method for testing body fluids by low pressure liquid chromatography - Google Patents

Method for testing body fluids by low pressure liquid chromatography

Info

Publication number
GB2220369B
GB2220369B GB8813761A GB8813761A GB2220369B GB 2220369 B GB2220369 B GB 2220369B GB 8813761 A GB8813761 A GB 8813761A GB 8813761 A GB8813761 A GB 8813761A GB 2220369 B GB2220369 B GB 2220369B
Authority
GB
United Kingdom
Prior art keywords
low pressure
liquid chromatography
pressure liquid
body fluids
testing body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8813761A
Other versions
GB8813761D0 (en
GB2220369A (en
Inventor
Nils Magnus Hjelm
Keith Raymond Drew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Child Health UCL
Original Assignee
Institute of Child Health UCL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Child Health UCL filed Critical Institute of Child Health UCL
Priority to GB8813761A priority Critical patent/GB2220369B/en
Publication of GB8813761D0 publication Critical patent/GB8813761D0/en
Priority to EP89305720A priority patent/EP0346082A1/en
Priority to DK282189A priority patent/DK282189A/en
Priority to JP1149276A priority patent/JPH02236164A/en
Publication of GB2220369A publication Critical patent/GB2220369A/en
Priority to GB9200162A priority patent/GB2250692A/en
Priority to GB9200161A priority patent/GB2250691A/en
Application granted granted Critical
Publication of GB2220369B publication Critical patent/GB2220369B/en
Priority to US08/729,033 priority patent/US5730867A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G01N2030/565—Packing methods or coating methods packing slurry packing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00564—Handling or washing solid phase elements, e.g. beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6047—Construction of the column with supporting means; Holders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8651—Recording, data aquisition, archiving and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
GB8813761A 1988-06-10 1988-06-10 Method for testing body fluids by low pressure liquid chromatography Expired - Lifetime GB2220369B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB8813761A GB2220369B (en) 1988-06-10 1988-06-10 Method for testing body fluids by low pressure liquid chromatography
EP89305720A EP0346082A1 (en) 1988-06-10 1989-06-07 Method and apparatus for low pressure liquid chromatography
DK282189A DK282189A (en) 1988-06-10 1989-06-09 METHOD AND APPARATUS FOR LOW PRESSURE CHROMATOGRAPHY
JP1149276A JPH02236164A (en) 1988-06-10 1989-06-12 Low pressure liquid chromatography apparatus,chromatography column and manufacture thereof and aupplementary pack for low pressure liquid chromatography
GB9200162A GB2250692A (en) 1988-06-10 1992-01-06 Chromatography column for use in apparatus for low pressure chromatography and packing method therefor
GB9200161A GB2250691A (en) 1988-06-10 1992-01-06 Apparatus for low pressure liquid chromatography
US08/729,033 US5730867A (en) 1988-06-10 1996-10-09 Method and apparatus for low pressure liquid chromatography

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8813761A GB2220369B (en) 1988-06-10 1988-06-10 Method for testing body fluids by low pressure liquid chromatography
US08/729,033 US5730867A (en) 1988-06-10 1996-10-09 Method and apparatus for low pressure liquid chromatography

Publications (3)

Publication Number Publication Date
GB8813761D0 GB8813761D0 (en) 1988-07-13
GB2220369A GB2220369A (en) 1990-01-10
GB2220369B true GB2220369B (en) 1993-01-27

Family

ID=26293999

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8813761A Expired - Lifetime GB2220369B (en) 1988-06-10 1988-06-10 Method for testing body fluids by low pressure liquid chromatography

Country Status (5)

Country Link
US (1) US5730867A (en)
EP (1) EP0346082A1 (en)
JP (1) JPH02236164A (en)
DK (1) DK282189A (en)
GB (1) GB2220369B (en)

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JPH07198701A (en) * 1993-11-26 1995-08-01 Ngk Insulators Ltd Column and column device for low-pressure high-precision liquid chromatography and method for using column device
JP2000298122A (en) * 1999-04-14 2000-10-24 Shimadzu Corp Liquid chromatograph
US6299767B1 (en) 1999-10-29 2001-10-09 Waters Investments Limited High pressure capillary liquid chromatography solvent delivery system
US6460420B1 (en) * 2000-04-13 2002-10-08 Sandia National Laboratories Flowmeter for pressure-driven chromatography systems
US6893569B2 (en) * 2003-06-16 2005-05-17 Sielc Technologies Method and apparatus for high pressure liquid chromatography
US7208087B2 (en) * 2005-02-15 2007-04-24 Bio-Rad Laboratories, Inc. Dual-chamber chromatographic cartridge
US7635433B2 (en) * 2005-08-26 2009-12-22 Agilent Technologies, Inc. System and method for feature alignment
JP2011141120A (en) * 2008-10-07 2011-07-21 Arkray Inc Liquid chromatography device and liquid chromatography
CN102803948B (en) 2009-06-09 2015-11-25 通用电气健康护理生物科学股份公司 Robotization fluid handling system
JP5013560B2 (en) * 2010-02-02 2012-08-29 積水メディカル株式会社 Method for analyzing hemoglobin S and method for analyzing hemoglobin A2
US9580822B2 (en) 2011-08-23 2017-02-28 Board Of Regents, The University Of Texas System Three-electrode buffer generator and method

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USRE29454E (en) * 1972-06-26 1977-10-25 E. I. Du Pont De Nemours And Company Method for producing a gradient elution
US4437812A (en) * 1977-05-13 1984-03-20 Varian Associates, Inc. Single-pump multiple stroke proportioning for gradient elution liquid chromatography
US4116046A (en) * 1977-08-05 1978-09-26 Hoffmann-La Roche Inc. Liquid chromatography system
US4142857A (en) * 1977-12-02 1979-03-06 Isolab, Incorporated Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor
US4168147A (en) * 1977-12-02 1979-09-18 Isolab, Inc. Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor
EP0008921A1 (en) * 1978-09-08 1980-03-19 Wright Scientific Limited Column chromatography and like processes and apparatus for the practice thereof
US4243534A (en) * 1979-01-25 1981-01-06 Becton, Dickinson And Company Blood separation
US4270921A (en) * 1979-09-24 1981-06-02 Graas Joseph E Microchromatographic device and method for rapid determination of a desired substance
FR2466773A1 (en) * 1979-09-28 1981-04-10 Prolabo Sa SAMPLE SCAN AND INJECTION DEVICE AND AT LEAST ONE STANDARD FOR A CHROMATOGRAPH
US4238196A (en) * 1979-11-01 1980-12-09 Isolab, Inc. Methods to determine a diagnostic indicator of blood sugar conditions, and, liquid chromatographic columns therefor (cyanide free)
FR2484858A1 (en) * 1980-04-21 1981-12-24 Hitachi Chemical Co Ltd PRE-COLUMN AND CARTRIDGE COLUMN FOR LIQUID-PHASE CHROMATOGRAPHY
DE3021366A1 (en) * 1980-06-06 1981-12-17 Merck Patent Gmbh, 6100 Darmstadt SEPARATION COLUMN FOR THE LIQUID CHROMATOR GRAPHI
DE3143075A1 (en) * 1981-10-30 1983-05-11 Merck Patent Gmbh, 6100 Darmstadt COLUMN CLAMPING DEVICE FOR CHROMATOGRAPHY "
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US4409335A (en) * 1982-05-28 1983-10-11 Bio-Rad Laboratories, Inc. Method for eliminating glucose dependent Schiff base effect from hemoglobin A1 assay
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Also Published As

Publication number Publication date
JPH02236164A (en) 1990-09-19
EP0346082A1 (en) 1989-12-13
GB8813761D0 (en) 1988-07-13
DK282189A (en) 1990-02-16
GB2220369A (en) 1990-01-10
US5730867A (en) 1998-03-24
DK282189D0 (en) 1989-06-09

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Expiry date: 20080609