GB2138292A - Haloalkynes and their use as fungicides - Google Patents
Haloalkynes and their use as fungicides Download PDFInfo
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- GB2138292A GB2138292A GB08321930A GB8321930A GB2138292A GB 2138292 A GB2138292 A GB 2138292A GB 08321930 A GB08321930 A GB 08321930A GB 8321930 A GB8321930 A GB 8321930A GB 2138292 A GB2138292 A GB 2138292A
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- propynyl
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/20—N-Aryl derivatives thereof
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A method for controlling the growth of algae and algae-like micro-organisms, comprises contacting the micro-organisms with a urethane compound of the formula [I-C IDENTICAL C-(CH2)n-OOC-NH-]mR in which m is 1, 2 or 3; n is 1, 2 or 3; and R is an alkyl, aryl, aralkyl, alkaryl, alkenyl, cycloalkyl or cycloalkenyl compound having from 1 to 20 carbon atoms and, optionally, substituents in addition to them urethane substituents given in the formula. Certain urethanes of the given formula are novel. The urethanes can be incorporated into coating compositions, e.g. paints.
Description
SPECIFICATION
Haloalkynes and their use as fungicides
This invention relates to haloalkynes and their use as fungicides.
Known fungicides include mercury compounds. They have limited effectiveness and toxicity shortcomings. Copper compounds have practical activity, but a disadvantage, for many applications, is that they are coloured. Tributyltin oxide has been used, but it is relatively expensive and shows unsatisfactory stability for exterior exposure.
For special applications in water towers such as cooling and holding towers, materials such as chlorine and sodium hypochlorite have been used. However, these materials are presently considered unacceptable by the U.S. Environmental Protection Agency at least, and may be environmentally hazardous.
Although various compounds have been employed for limited use in lakes, ponds and areas of stagnant water, there has not been a wide recognition of the need for algacides in coatings until recently. It has been found possible to "load" certain compositions with materials such as zinc oxide, but this causes problems in pigmented paints and coatings, has low algacidal activity and gives stability problems.
Certain carbamates have been employed as insecticides and herbicides. The insecticide Seven (carbamyl or naphthylmethyl carbamate) is known to be algacidal at between 1 and 100 ppm. However, even when tested at 100 ppm, it only reduced the population of an axenic culture of Chlorella pyrenoidosa by 30% (Christie, 1969, "Pesticide Microbiology").
"Zectran", a mexacarbate formulation, has been claimed to prevent photosynthesis in blue-green algae (bacteria). However, in "normal" spray applications it did not pose a threat to aquatic algae (Snyder and Sharidan, 1974).
Phenylcarbamates, frequently employed as herbicides, have demonstrated activity against blue-green algae (bacteria). Propham, Chloropropham and Barban have caused a 50% reduction in the growth of blue-green algae in the range between 0.3 and 70 ppm (data from Hill and Wright, 1978). Barban did not inhibit all of the algae species tested.
US-A-3,923,870 describes urethanes of 1-halogen-substituted alkynes and their fungicidal activity.
US-A-4,276,21 1 describes the use of urethanes of 1-halogen-substituted alkynes and combinations of these compounds with epoxides to provide colour-stabilised fungicides for use in coatings.
According to the present invention, a method for controlling the growth of algae and algae-like micro-organism comprises contacting the micro-organisms with a urethane compound of the formula [lC=C(CH2)nOOCNH]mR in which m is 1,2 or 3; n is 1,2 or 3; and R is an alkyl, aryl, aralkyl, alkaryl, alkenyl, cycloalkyl or cycloalKenyl compound having no more than 20 carbon atoms and, optionally, substituents in addition to the m urethane substituents given in the formula.
Novel compounds of the invention are those urethane compounds of the given formula, in which R is an aralkane or substituted aryl compound.
M and n are each integers, and may be the same or different. It is often preferred that either or both should be one. A particularly preferred compound for use in the method of the invention is 3-iodo-2-propynyl
N-butylcarbamate. This compound is also known under the trade name Polyphase.
Urethane compounds used in this invention can be of considerable utility as algacides, for controlling and destroying many different species of algae and algae-like micro-organisms. They can be very stable, even when incorporated into aqueous and non-aqueous compositions. They are often deactivated and/or destroyed only by prolonged exposure to high temperatures.
The urethane compounds used in the invention can possess only low toxicity towards animals (including domestic animals), birds and other wildlife, and towards man. Consequently, their use in the algacidal compositions requires only the usual good practice and procedures in handling. Such precautions are of course well established.
Laboratory tests have indicated that the urethane compounds used in the invention can be combined with other biocides as desired. Combination can both broaden and enhance activity and extend areas of utility.
The urethane compounds used in the invention may be incorporated into protective, decorative and/or coating compositions. Such compositions may contain a wide variety of conventionai components in addition to the urethane compound. Such compositions may comprise, for example, from 0.01 to 12% by weight of the urethane compound. The exact concentration to be used will often depend on the stability of the urethane compound in the compositions in which it is used, and on the nature, e.g. aqueous or non-aqueous, of the composition. Higher concentrations, e.g. up to 40% by weight, may be necessary where it is desired to control and/or destroy particular micro-organisms, e.g. in conditions of well-established growth.
For use in the invention, the urethane compounds may be employed as premixed dispersions. They may also be prepared as solutions or dispersions and thereafter added to protective compositions. For example, 3-iodo-2-propynyl N-butylcarbamate is found to be soluble in water at a level of about 15-200 ppm.
Urethanes may be used, according to the invention, in a variety of compositions requiring protection and freedom from algal growth, including wood, mortar, many paints, coatings, corkings and fillers. Urethanes can be used against algal species found in marine, fresh water, terrestial and aerial loci. They can be used against algae found in water-cooling towers and irrigation canals.
Compositions in which the urethane compounds may be incorporated include all types of water-based latex paints including acrylic and pva latex paints, chlorinated rubber-vinyl paints, oil alkyl paints, oil-based stains, pigmented paints and protective and decorative compositions, rubber and/or asphalt-containing roof coatings, inorganic and polymeric caulkings, moulding materials, sealants, silicone compositions and liquid compositions, both aqueous and non-aqueous, adapted for painting, dipping or spraying.
It has been found that the urethane compounds used in the invention are particularly valuable for applications in, for example, irrigation ditches, canals and conduits clogged by Batrachospermun (red algae).
It is also possible to use these algacidal compounds for control of the so-called "red tide" problem which is generally caused by one or more algal species from the class Dinophyceae.
The compounds may also be used to prevent odours by controlling, limiting and/or destroying the algal population in water, such as in irrigation systems, water towers, recirculating sewage water systems and similar water-holding and transporting systems.
Algal groups which can be treated effectively by the method of this invention include algae in the divisions
Chlorophyta (green algae), Chrysophyta (yeliow-green algae), Cyanophyta (blue-green algae or bacteria),
Euglenophyta (euglenoides), Phaeophyta (brown algae) and Rhodophyta (red algae).
The following Examples illustrate the invention, or are for the purposes of comparison.
It is well known that it is usually easier to control or prevent growth than it is to kill an already-growing algal population. It is also known to be easier to control a small ratherthan a large population of algal organisms. The Examples are especially intended to show the algacidal properties of the tested compounds, and compositions containing them, and particularly to show illustrative data on the effectiveness of the compositions for such species as are protected by thick capsules as well as those which grow and multiply rapidiy as thick colonies, such as Scytonema species which have thick capsules and Nostoc species which grow as thick colonies.
The algae used for testing the compounds and compositions for algae control and algacidal activity were obtained from Ward's Natural Science Establishment of Rochester, N.Y., U.S.A.
Example 1
3-lodo-2-propynyl N-(4-chlorophenyl) carbamate 0.2 mole 3-hydroxy-1-iodopropyne (HIP) as a 70% solution in ether, dried with an hydros sodium sulfate, was mixed with 0.2 mole p-chlorophenyl isocyanate.
Afew drops of dibutyltin dilaurate were added, as catalyst. An exothermic reaction took place. The mixture was refluxed until the reaction was complete. A yield of 21 g of pale cream precipitate, approximate m.p.
95-100"C, was filtered from the clear filtrate. Partial evaporation yielded 22 g of additional precipitate, m.p.
93-95"C. % iodine = 36.8; theoretical = 37.8%
Example 2
3-lodo-2-propynyl N-(3-methyl phenyl )ca rbamate
The procedure of Example 1 was followed, except that m-tolyi isocyanate was used instead of p-chlorophenyl isocyanate. The product was isolated from the reaction mixture after standing in a freezer overnight, after an initial filtration to remove a small amount of sediment. The yield was 37 g of paie cream crystals, melting point 93"C. % lodene = 39.97; theoretical = 40.2%.
Example 3
Di(3-iodo-2-propynyl) N,N'-toluene-2,4- and 2,6-dicarbamate
HIP was reacted with a commercial preparation of mixed isomers (80% 2,4- and 20% 2,6-isomers) of toluene diisocyanate known an MondurTD-30, a product produced by Mobay Chemical Co.
60 g of a 72% solution of HIP in ether were mixed with 200 g methylene chloride and 0.33 cc dibutyltin dilaurate, and 19.2 g Mondur TD-30 were added slowly over a period of 50 minutes. When all reactant had been added, the mixture was heated to reflux and methylene chloride was added as required (about 250 g in ali) to keep the precipitate that forms dispersed. The reaction mixture was held at reflux for 2.5 hours and allowed to stand overnight. The following morning, it was filtered to obtain 51 g of a cream-coloured powder melting at 174-177"C.
Example 4
Di(3-iodo-2-propynyl) N,N'-diphenylmethane-4,4'-dicarbamate
The procedure of Example 3 was followed except that the isocyanate used was diphenylmethane-4,4'isocyanate, obtained as Mondur M from Mobay Chemical. The reaction of 39 g HIP and 25 g Mondur M yielded 55.5 g of a cream-coloured powder, m.p. 165-168"C and iodine content 40% (theoretical = 41.4%).
Example 5
Di(3-iodo-2-propynyl) N,N'-toluene-2,4-dicarbamate The procedure of Example 3 was followed except that toluene-2,4-diisocyanate (Mondur TDS, Mobay
Chemical) was used. The yield was 52 g of a cream-coloured powder, approximate m.p. 181-184"C and iodine content 47% (theoretical = 47.2%).
Example 6
3-lodo-2-propynyl N-(phenyl methyl)carbamate
14.6 g HIP were dissolved in 20 cc ether. 0.1 cc dibutyltin dilaurate was added 16.7 g benzyl isocyanate were added over 0.5 hour. The temperature rose to 39"C and there was precipitation. Mixing was continued for an additional 0.5 hour. The reaction mixture was filtered and washed with ether to yield 20.5 g of a cream-coloured powder, m.p. 107-1 10'C. This product was reslurried with ether; refiltration yielded 17.5 g of very pale cream crystals, m.p. = 112-113"C. % iodine = 39.4; theoretical = 40.3%.
Example 7
Polyphase (3-iodo-2-propynyl N-butylcarbamate) was tested for algacidal activity. Erdschreiber's solution (a well-known marine salt growth medium) was combined in various amounts with various quantities of an aqueous solution containing 100 mg/1 Polyphase or, in a final experiment, water, to a total of 7 ml, in screw-capped tubes. The tubes were each inoculated with 3 ml of an active culture of Prorocentrum (which grows well on the medium).The amounts of medium and resultant Polyphase concentrations are set out in
Table 1:
TABLE 1
Erdschreiber's Polyphase
solution concentration
(ml) (mg/1)
7.00 0
6.50 5.0
6.00 10.0
5.50 15.0
5.00 20.0
4.50 25.0
4.00 30.0
3.50 35.0
3.00 40.0
2.50 45.0
2.00 50.0
2.00 0
After the tubes were inoculated with Prorocentrum, they were incubated under cool whire fluorescent light (40W) at about 20"C for 2 days. They were then examined microscopically. Viable (motile) cells were observed both in control tubes without Polyphase and in the tubes containing 5 mg of Polyphase per 1. No viable cells were observed in the tubes containing concentrations of 10 mg/l or more Polyphase.
When species of green algae were employed as the inoculum, chlorosis (the bleaching or disappearance of the green colour) could often be employed to detect the toxic level of Polyphase to the algae. Microscopic examination, chlorosis or both was employed to study these species. These techniques were repeated with other unicellular and/or microscopic algal species, the test results being shown in Table 2.
Example 8
Further solutions were prepared as described, in Examples 7, except that the final volume in each instance, without the inoculum, was 10 ml. The inocuium consisted of filaments of algal species such as Spirogyra and
Scytonema, cut pieces of large marine algae such as Ulva, and marble size colonies of species such as
Nostoc. The small amount of water adhering to the filaments, pieces and colonies was ignored. Chlorosis was employed to detect the algacidal acitivity of Polyphase.
Both fresh-water and marine species were tested as described in Example 7, the results being summarised in Table 2. It was shown that Polyphase demonstrated excellent algacidal acitivity against both groups of organisims. Marine algae are separated in Table 3. That shows that Polyphase at least could have applications in the treatment of marine algal blooms, such as "red tides".
Since Polyphase is soluble in water to the extent of about 175 ppm, and analogues of varying solubility in water are available, it was concluded that saturated solutions in water would contain sufficient biocide to control the hardiest algae.
TABLE 2
Toxic Level of
Organism Polyphase (mg/1)
Division Chlorophyta (Green Algae) 5 - 40
Class Chlorophyceae
Order Volvocales 10-20 1. Carteria s p. 10
2. Chlamydomonas rhinhardtii 15 3. Eudorina s p. 20
4. Haematoccus sp. 10 5. Pandorina s p. 20
6. Platymonas sp. 10
7. Volvoxsp 20
Order Ulotrichales
8. Ulothrixsp. 40
Order Ulvales 9.Ulvasp. 30
Order Oedogoniales 10. Oedogonium sp. 15
Order Cladophorales 11. Cladophorasp. 25 12. Pithophora sp. 25
Order Chlorococcales 5 - 20 13. Ankistrodesmus sp. 10 14. Chlorella pyreniodosa 20 15.Hydrodictyon sp. 5 16. Protosiphon sp. 10 17.Scenedesmus sp. 5 Order Zygnematales 15-30 18. Closterium sp. 30 19. Mougeotia sp 20 20. Spirogyra sp. 15
Class Charophyceae
Order Charales 21. Nftella sp. 5
Division Chrysophyta (Yellow-Green Algae) 15 - 35
Class Xanthophyceae
Order Heterotrichales 22. Botrydiopsis sp. 30 23. Tribonemasp. 15
Order Heterosiphonales 24. Botrydium s p. 20 25. Vaucheria sp. 10
Class Chrysophyceae
Order Chrysomonadales 26. Synnra sp. 15
Class Baclllariophyceae Order Pennales 27. Navicula sp. 35
Division Euglenophyta
Order Eugleniales 28. Astasia sp. 15 29. Euglena gracllis (green form) 35 30. Phacus sp. 15 31.Trachelomonas sp. 5
Division Pyrrophyta (Desmokontes and
Dinoflagellates)
Class Desmokontae
Order Desmonadales 32. Prorocentrum sp. 10
Class Dinophyceae order Perdiniales 33. Peridinium sp. 15
Division Rhodophyta (Red Algae)
Subclass Bangiodeae 34. Porphyridium sp. 15
Subclass Florideae 35. Batrachospermun sp. 35
Uncertain Systematic Position 36. Rhodochorton sp. 30
Uncertain Systematic Position
Class Cryptophyceae
Order Cryptomonodales 37. Chilomonas sp. 25
Division Cyanophyta (CyanobacteriaJ Class Myxophyceae fMyxobacteria) [Blue-Green Algae (Bacteria)l 15 - 75
Order Chroococcales 40 - 60 38. Anacystis sp. 60 39. Gloeocapsa sp. 40 40. Merismopedia sp. 55 order Oscillatoriales 15 - 75 41.Anabaenaxp. 35 42. Cylindrospermum sp. 15 43. Gloeotrichia sp. 40 44. Lyngbya sp. 65 45. Nostoc sp. 55 46. Osclllatoria sp. 60 47. Phormidium sp. 75 48. Scytonema sp. 60 49. Spirulina sp. 25 50. Tolypothrixsp. 40
TABLE 3
Toxic level of
Organism Polyphase (mg/1)
Division Chlorophyta (Green Algae)
Order Volvocales 1. Platymonas sp. 20
Order Ulvales 2. Ulna sup 30
Division Chrysophyta (Yellow Green Algae)
Order Chrysomonadales 3. Synura sp. 15
Division Pyrrophyta
Order Desmonadales 4. Prorocentrum sp. 10
Division Rhodophyta
Order Bangiales 5. Posphridium sp. 15
Uncertain Systematic Position 6. Rhodochorton sp. 30
Division Cyanobacteria 7. Spirulina 25
Division Phaeophyta (Brown Algae) 8.Fuscus 65
Protease agar plates were prepared and seeded with a "lawn" of Chlorella pyrenoidosa from an axenic culture. Treated, air-dried discs, containing Polyphase, or an analogue as identified in Table 4, were placed in the centre of each plate. The dishes were incubated under a cool white fluorescent light (40W) at about 20"C until algal growth was obtained (about 6 days). The size of the zone of inhibition was measured from the edge of the disc to the edge of the algal growth. The data obtained are reported in Table 5.
TABLE 4
Compound (see given formula) Reference (Example) m n R 1 1 1-butyl A(Polyphase) 1 2 methyl B 1 1 phenyl C 1 1 ethyl D 1 1 cyclopropyl E 1 1 1-hexyl F 1 1 1-octyl G 1 1 4-chlorophenyl H (1) 1 1 m-tolyl 1(2) f 80% 2,4-tolyl 2 1 , J (3) 20% 2,6-toloyg 2 1 4,4'-diphenylmethane K (4) 2 1 2,4-tolyl L (5) 1 1 benzyl M (6) TABLE 5
Compound Concentration Inhibitory Zone
(%) (mm)
A 1.0 10
A 2.0 11
A 5.0 12
A 40.0 13
B 1.0 14
C 1.0 9
D 1.0 14
E 0.5 10
F 1.0 8
G 1.0 7
H 1.0 13
1.0 9
1.0 20
J 1.0 6
K 1.0 5
L 1.0 5
M 1.0 42
Example 9
Schleicher and Schnell Analytical Paper (No. 740-E, 12 mm) discs were dipped into 1-40% acetone
solutions of the compound to be tested. A 'T' pin pushed through the centre of each disc was employed to
hold it during dipping and subsequent drying. The treated discs were air-dried by holding them on the 'T'
pins pushed into corkboard.
Example 10
An oil alkyd paint was prepared from the following:
Material Amout (1.)
Heat-bodied linseed oil 127
Alkali-refined linseed oil 45
Beckosol P296-60 (60% dry weight) 45
Mineral Spirits 136
Cobalt drier 6% 1.4
Calcium drier 6% 2.7
Anti-skinning agent 0.9
Non-chalking titanium dioxide 40
Talc 57
Suspending agent 1.4
Polyphase was added at various levels. Filter paper sheets were coated or treated with the formulations (or
without Polyphase) and dried. Discs 12 mm in diameter were cut from the sheets. These discs were placed
on plates containing proteose agar which had been seeded with a lawn of Chlorella pyrenoidosa and
incubated as described in Example 9. Zones of inhibition were measured as described in Example 9. The test
results are recorded in Table 6.
Example 11
A white alkyd oil stain was prepared from the following:
Material Amout (1.)
Titanium dioxide 6.64
Suspension agent 1.36
Beckosol P296-60 82.7
Raw linseed oil 49.78
Mineral spirits 313.0
Cobalt drier 6% 0.55
Calcium drier 6% 1.59
Anti-skimming agent 0.59
This was tested as described in Example 10, and inhibition zone measurements are recorded in Table 6.
Example 12
An acrylic latex paint was prepared from the following:
Material Amount (1.)
Water 193
Cellosize QP-1 5000 1.4
Tamol 731 (25% dry weight) 5.0
Lecithin 0.9
Ethylene glycol 7.3
Carbitol 5.5
Defoamer-999 5.9
Titanium dioxide 36.8
Talc 16.4
Mica 9.5
Rhoplex AC35 (46% dry weight) 183
This was tested as described in Example 11, and inhibition zone measurements are recorded in Table 6.
TABLE 6
Example Polyphase (g/l) Zone of
Inhibition (mm)
10 0 (control) 4
10 2 6
10 4 10
10 6 13
11 0(control) 6
11 3 8
11 4 10
11 6 13
12 0 (control) 0 12 6 4
It was observed that a small zone of inhibition was obtained on controls (which did not contain Polyphase)
This apparent anomaly is caused by the solvents and biocides which are normally added to paints and other coatings to protect them from bacterial growth. However, after application as coatings, these toxic agents are removed by weathering, leaving the coatings unprotected. Larger zones of inhibition were observed in
Polyphase-protected coatings. These results clearly demonstrate the added and prolonged protection of
Polyphase use.
Example 13
Traycote is a protective roofing coating having the following composition:
Material Amout (g/l)
Ethylene glycol 23.3
Natrasol 250HR 4.0
Water 197.8
Nopco NYZ 93.2
Tamol 250 4.7
Calcium carbamate 93.2
Titanium dioxide 65.3
Talc 279.5
Acrylic latex resin 442.6
Aqueous ammonia (26 Baume) 1.9
Troysan 174 2.5
(Troysan 174 is a volatile bactericide employed for "in-can" preservation).
Polyphase was added at levels between 0.1 and 1.0% w/v to this roof coating material. The compositions were coated onto 25 mm x 76 mm glass microscope slides, allowed to dry for 2 days, and then leached with distilled water for 3 days. The coatings were cut from the slides using a razor blade and plated onto proteose agar covered with a lawn of Chlorella pyrenoidosa cells. The plates were incubated under cool white fluorescent light (40W) for 2 days and examined. A green "lawn" of algal cells was observed growing to the edge of a control coating (without Polyphase). The observation included growth under the surface of the control coating (as viewed in reflected light); however, no growth whatever was observed under coating samples containing at least 0.4% Polyphase. In addition, zones of inhibition between 0.5 and 4.0 mm wide were observed around the protected coatings.
Example 14
A commercially-available rubberised asphalt roof coating composition was tested, which has the following composition:
Material
Asphalt 50
Attagel (thickener) 15 Kraton rubber < 5
Lecithin and surfactants < 1
Aromatic process oil < 5
High flash naphtha 24-25
This coating material was combined with Troysan Polyphase Af-1 formulation. The active Polyphase content of this formulation is 40% and the remaining inert ingredients are solvents. Various mixtures contained 0.0, 0.5, 1.0, 1.5 or 2.0 % Polyphase AF-1 (0.0, 0.2,0.4, 0.6 or 0.8 % w/w active Polyphase).
These samples were applied to glass slides with a wooden tongue depressor, and dried for 3 days. They were removed from the slides with a razor blade and placed, smooth surface down, on the surface of proteose agar plates seeded with Chlorella pyrenoidosa. The samples were incubated for 7 days under 40W white fluorescent light at ambient temperature (about 22"C).
Chlorella pyrenoidosa grew up to and under the surface of the control sample (not containing Polyphase).
Its growth was inhibited and it failed to grow under the surface of samples containing Polyphase at all concentration levels. Zones of inhibition were observed at 0.6 and 0.8% active Polyphase.
Example 15
Solutions of Poylphase in ethanol were prepared at levels of 0.0, 0.1, 0.2,0.4, 0.6, 0.8 and 1.0 g/1 00 ml. The solutions were transferred to an "Omit" air dispenser and sprayed onto the surface of proteose agar in Petri dishes. The proteose agar had previously been inoculated with Chlorella pyrenoidosa which would grow to produce a "lawn" of cells upon the surface. The Petri dishes were incubated under 40W cool white fluorescent light for one week at ambient temperature (about 22"C).
Chlorella pyrenoidosa grew covering the surface of the agar sprayed with ethanol which did not contain
Polyphase. Some spotty growth occurred at the 0.1 and 0.2 9/100 ml Polyphase levels. No growth at all was observed on plates having higher levels of Polyphase.
Claims (13)
1. A method for controlling the growth of algae and algae-like micro-organisms, which comprises contacting the micro-organisms with a urethane compound of the formula [I-CsC(CH2)nOOCNH]mR in which m is 1,2 or 3; n is 1,2 or 3; and R is an alkyl, aryl, aralkyl, alkaryl, alkenyl, cycloalkyl or cycloalkenyl compound having from 1 to 20 carbon atoms and, optionally, substituents in addition to the m urethane substituents given in the formula.
2. A method according to claim 1, in which m is 1.
3. A method according to claim 1 or claim 2, in which n is 1.
4. A method according to claim 1, in which the urethane compound is 3-iodo-2-propynyl Nbutylcarbamate.
5. A urethane compound of the formula defined in any of claims 1 to 3, in which R is an aralkane or substituted aryl compound.
6. 3-lodo-2-propynyl N-(4-chlorophenyl)carbamate.
7. 3-lodo-2-propynyl N-(3-methyl phenyl )ca rba mate.
8. Di(3-iodo-2-propynyl) N,N'-toluene-2,4-dicarbamate.
9. Di(3-iodo-2-propynyl) N,N '-tol uene-2,6-dicarbamate.
10. Di(3-iodo-2-propynyl) N,N '-diphenylmethane-4,4'-dicarbamate.
11. 3-lodo-2-propynyl N-(phenylmethyl)carbamate.
12. A method according to claim 1, in which the urethane compound is as claimed in any of claims 5 to 11.
13. A composition adapted to coat a substrate, which comprises a urethane of the formula defined in any of claims 1 to 4 or as claimed in any of claims 5 to 11.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08409835A GB2140299B (en) | 1983-04-18 | 1984-04-16 | Use of haloalkynyl carbamates in treating micro-organisms |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48578683A | 1983-04-18 | 1983-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2138292A true GB2138292A (en) | 1984-10-24 |
GB2138292B GB2138292B (en) | 1986-09-03 |
Family
ID=23929436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08321930A Expired GB2138292B (en) | 1983-04-18 | 1983-08-15 | Haloalkynes and their use as fungicides |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS59193860A (en) |
AU (1) | AU583010B2 (en) |
CA (1) | CA1259626A (en) |
GB (1) | GB2138292B (en) |
NL (1) | NL8302643A (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257888A2 (en) * | 1986-08-26 | 1988-03-02 | Sumitomo Chemical Company, Limited | An iodopropargyl carbamate derivative, a method for its production and fungicidal compositions containing it as an active ingredient |
EP0258030A2 (en) * | 1986-08-26 | 1988-03-02 | Sumitomo Chemical Company, Limited | A fungicidal composition containing an iodopropargyl carbamate |
US4915909A (en) * | 1988-10-05 | 1990-04-10 | Nalco Chemical Company | Method of controlling algae growth |
EP0365121A1 (en) * | 1988-08-24 | 1990-04-25 | Buckman Laboratories International, Inc. | Ester of carbamic acid useful as a microbicide and preservative |
US5071479A (en) * | 1990-01-22 | 1991-12-10 | Troy Chemical Corporation | Biocidal compositions |
EP0522398A1 (en) * | 1991-07-11 | 1993-01-13 | Bayer Ag | Microbicidal compositions |
EP0547480A1 (en) * | 1991-12-19 | 1993-06-23 | Bayer Ag | Microbicidal agents |
WO1993024010A1 (en) * | 1992-05-29 | 1993-12-09 | Henkel Kommanditgesellschaft Auf Aktien | Active biocidal agents |
WO1994002451A1 (en) * | 1992-07-24 | 1994-02-03 | Troy Chemical Corporation | Halo alkynyl urea derivatives, a method for their production and fongicidal compositions containing them |
WO1996039836A1 (en) * | 1995-06-07 | 1996-12-19 | Troy Chemical Company | Method of stabilizing biocidal compositions of haloalkynyl compounds |
US5707929A (en) * | 1995-05-08 | 1998-01-13 | Troy Chemical Corporation | Biocidal compositions comprising mixtures of haloproynyl compounds and sulfur containing triazines |
US5916930A (en) * | 1996-11-20 | 1999-06-29 | Troy Corporation | Stabilization of biocidal activity in air drying alkyds |
US5938825A (en) * | 1998-05-21 | 1999-08-17 | Troy Technology Corporation Inc. | Stabilized antimicrobial compositions containing halopropynyl compounds |
US6059991A (en) * | 1997-12-12 | 2000-05-09 | Troy Technology Corporation, Inc. | Stabilized composition containing halopropynyl compounds |
US6140370A (en) * | 1998-09-21 | 2000-10-31 | Troy Technology Corporation, Inc. | Stabilized alkyd based compositions containing halopropynl compounds |
US6472424B1 (en) | 2000-06-07 | 2002-10-29 | Troy Technology Corporation, Inc. | Stabilized antimicrobial compositions containing halopropynyl compounds and benzylidene camphors |
EP2366554A3 (en) * | 2010-03-16 | 2012-10-24 | Ricoh Company, Ltd. | Thermosensitive recording medium |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1258227A (en) * | 1983-04-18 | 1989-08-08 | Charles C. Versfelt | Repellents and toxicants for aquatic invertebrate animals from urethanes of 1-halogen substituted alkynes and compositions containing same and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923870A (en) * | 1973-07-11 | 1975-12-02 | Troy Chemical Corp | Urethanes of 1-halogen substituted alkynes |
EP0014032B1 (en) * | 1979-01-22 | 1983-03-23 | Imperial Chemical Industries Plc | Process for the preparation of iodoalkynyl carbamates |
US4276211A (en) * | 1980-03-10 | 1981-06-30 | Troy Chemical Corporation | Stabilization composition for coating composition |
-
1983
- 1983-07-22 CA CA000432968A patent/CA1259626A/en not_active Expired
- 1983-07-25 NL NL8302643A patent/NL8302643A/en active Search and Examination
- 1983-08-04 JP JP14198083A patent/JPS59193860A/en active Granted
- 1983-08-15 GB GB08321930A patent/GB2138292B/en not_active Expired
- 1983-08-15 AU AU17998/83A patent/AU583010B2/en not_active Ceased
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257888A2 (en) * | 1986-08-26 | 1988-03-02 | Sumitomo Chemical Company, Limited | An iodopropargyl carbamate derivative, a method for its production and fungicidal compositions containing it as an active ingredient |
EP0258030A2 (en) * | 1986-08-26 | 1988-03-02 | Sumitomo Chemical Company, Limited | A fungicidal composition containing an iodopropargyl carbamate |
EP0257888A3 (en) * | 1986-08-26 | 1988-09-21 | Sumitomo Chemical Company, Limited | An iodopropargyl carbamate derivative, a method for its production and fungicidal compositions containing it as an active ingredient |
EP0258030A3 (en) * | 1986-08-26 | 1988-09-21 | Sumitomo Chemical Company, Limited | A fungicidal composition containing an iodopropargyl carbamate |
US4841088A (en) * | 1986-08-26 | 1989-06-20 | Sumitomo Chemical Company, Limited | Iodopropargyl carbamate derivative, a method for its production and fungicidal compositions containing it as an active ingredient |
US4933366A (en) * | 1986-08-26 | 1990-06-12 | Sumitomo Chemical Company, Limited | Fungicidal composition |
EP0365121A1 (en) * | 1988-08-24 | 1990-04-25 | Buckman Laboratories International, Inc. | Ester of carbamic acid useful as a microbicide and preservative |
US4915909A (en) * | 1988-10-05 | 1990-04-10 | Nalco Chemical Company | Method of controlling algae growth |
US5071479A (en) * | 1990-01-22 | 1991-12-10 | Troy Chemical Corporation | Biocidal compositions |
US5190580A (en) * | 1990-01-22 | 1993-03-02 | Troy Chemical Corporation | Process of using biocidal compositions |
EP0522398A1 (en) * | 1991-07-11 | 1993-01-13 | Bayer Ag | Microbicidal compositions |
US5332765A (en) * | 1991-12-19 | 1994-07-26 | Bayer Aktiengesellschaft | Microbicidal agents |
EP0547480A1 (en) * | 1991-12-19 | 1993-06-23 | Bayer Ag | Microbicidal agents |
WO1993024010A1 (en) * | 1992-05-29 | 1993-12-09 | Henkel Kommanditgesellschaft Auf Aktien | Active biocidal agents |
WO1994002451A1 (en) * | 1992-07-24 | 1994-02-03 | Troy Chemical Corporation | Halo alkynyl urea derivatives, a method for their production and fongicidal compositions containing them |
US5948730A (en) * | 1995-05-08 | 1999-09-07 | Troy Chemical Corporation | Biocidal compositions comprising mixtures of haloproynyl compounds and sulfur containing triazines |
US5707929A (en) * | 1995-05-08 | 1998-01-13 | Troy Chemical Corporation | Biocidal compositions comprising mixtures of haloproynyl compounds and sulfur containing triazines |
US6017955A (en) * | 1995-06-07 | 2000-01-25 | Troy Technology Corporation, Inc. | Method of stabilizing biocidal compositions of haloalkynyl compounds |
WO1996039836A1 (en) * | 1995-06-07 | 1996-12-19 | Troy Chemical Company | Method of stabilizing biocidal compositions of haloalkynyl compounds |
US6124350A (en) * | 1995-06-07 | 2000-09-26 | Troy Technology Corporation, Inc. | Method of stabilizing biocidal compositions of haloalkynyl compounds |
EP1312261A1 (en) * | 1995-06-07 | 2003-05-21 | Troy Technology Corporation, Inc. | Aqueous compositions containing a haloalkynyl compound and a buffer for providing biocidal activity and for stabilising end-use formulations |
US5916930A (en) * | 1996-11-20 | 1999-06-29 | Troy Corporation | Stabilization of biocidal activity in air drying alkyds |
US6059991A (en) * | 1997-12-12 | 2000-05-09 | Troy Technology Corporation, Inc. | Stabilized composition containing halopropynyl compounds |
US6353021B1 (en) | 1997-12-12 | 2002-03-05 | Troy Technology Corporation, Inc. | Stabilized composition containing halopropynyl compounds |
US5938825A (en) * | 1998-05-21 | 1999-08-17 | Troy Technology Corporation Inc. | Stabilized antimicrobial compositions containing halopropynyl compounds |
US6140370A (en) * | 1998-09-21 | 2000-10-31 | Troy Technology Corporation, Inc. | Stabilized alkyd based compositions containing halopropynl compounds |
US6472424B1 (en) | 2000-06-07 | 2002-10-29 | Troy Technology Corporation, Inc. | Stabilized antimicrobial compositions containing halopropynyl compounds and benzylidene camphors |
EP2366554A3 (en) * | 2010-03-16 | 2012-10-24 | Ricoh Company, Ltd. | Thermosensitive recording medium |
US8709974B2 (en) | 2010-03-16 | 2014-04-29 | Ricoh Company, Ltd. | Thermosensitive recording medium |
Also Published As
Publication number | Publication date |
---|---|
AU583010B2 (en) | 1989-04-20 |
JPH049766B2 (en) | 1992-02-21 |
JPS59193860A (en) | 1984-11-02 |
NL8302643A (en) | 1984-11-16 |
GB2138292B (en) | 1986-09-03 |
AU1799883A (en) | 1984-10-25 |
CA1259626A (en) | 1989-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19990815 |