GB2116542B - Tetrahydroisoquinoline-3-carboxylic acids - Google Patents
Tetrahydroisoquinoline-3-carboxylic acidsInfo
- Publication number
- GB2116542B GB2116542B GB08234339A GB8234339A GB2116542B GB 2116542 B GB2116542 B GB 2116542B GB 08234339 A GB08234339 A GB 08234339A GB 8234339 A GB8234339 A GB 8234339A GB 2116542 B GB2116542 B GB 2116542B
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetrahydroisoquinoline
- carboxylic acids
- carboxylic
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3931779A | 1979-05-16 | 1979-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2116542A GB2116542A (en) | 1983-09-28 |
GB2116542B true GB2116542B (en) | 1984-02-15 |
Family
ID=21904828
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8012431A Expired GB2048863B (en) | 1979-05-16 | 1980-04-15 | Tetrahydroisoquinoline-3-carboxylic acids |
GB08234339A Expired GB2116542B (en) | 1979-05-16 | 1982-12-02 | Tetrahydroisoquinoline-3-carboxylic acids |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8012431A Expired GB2048863B (en) | 1979-05-16 | 1980-04-15 | Tetrahydroisoquinoline-3-carboxylic acids |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS55153769A (en) |
BE (1) | BE883320A (en) |
DE (1) | DE3018545A1 (en) |
FR (1) | FR2456733A1 (en) |
GB (2) | GB2048863B (en) |
IT (1) | IT1133009B (en) |
NL (1) | NL8002828A (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3044236A1 (en) * | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
US4595675A (en) * | 1979-09-19 | 1986-06-17 | Hoechst Aktiengesellschaft | Bicyclic α-iminocarboxylic acid compounds having hypotensive activity |
FR2487829A2 (en) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
FR2503155A2 (en) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
US5200416A (en) * | 1980-05-12 | 1993-04-06 | Usv Pharmaceutical Corporation | Cyclic amides |
US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4432971A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4427665A (en) | 1982-05-19 | 1984-01-24 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions |
US4736066A (en) * | 1982-07-19 | 1988-04-05 | E. R. Squibb & Sons, Inc. | Intermediate for substituted peptide compounds |
US4470973A (en) * | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
US4623729A (en) | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4621092A (en) * | 1982-07-22 | 1986-11-04 | E. R. Squibb & Sons, Inc. | Substituted proline compounds, composition and method of use |
US4742067A (en) * | 1982-07-22 | 1988-05-03 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4524212A (en) * | 1982-09-27 | 1985-06-18 | E. R. Squibb & Sons, Inc. | Acyloxyketone substituted imino and amino acids |
US4642315A (en) * | 1982-11-18 | 1987-02-10 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4456595A (en) * | 1982-12-06 | 1984-06-26 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy aroly peptides |
US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
EP0187037A3 (en) * | 1984-12-21 | 1988-03-23 | Takeda Chemical Industries, Ltd. | Piperidine derivatives, their production and use |
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5572169A (en) * | 1978-11-27 | 1980-05-30 | Tanabe Seiyaku Co Ltd | Isoquinoline derivative and its preparation |
EP0018104B1 (en) * | 1979-03-26 | 1983-05-25 | Takeda Chemical Industries, Ltd. | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
FR2470767A1 (en) * | 1979-12-07 | 1981-06-12 | Science Union & Cie | N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s) |
-
1980
- 1980-04-15 GB GB8012431A patent/GB2048863B/en not_active Expired
- 1980-05-14 NL NL8002828A patent/NL8002828A/en not_active Application Discontinuation
- 1980-05-14 IT IT48675/80A patent/IT1133009B/en active
- 1980-05-14 DE DE19803018545 patent/DE3018545A1/en not_active Withdrawn
- 1980-05-14 BE BE0/200636A patent/BE883320A/en unknown
- 1980-05-14 FR FR8010941A patent/FR2456733A1/en active Granted
- 1980-05-16 JP JP6518380A patent/JPS55153769A/en active Pending
-
1982
- 1982-12-02 GB GB08234339A patent/GB2116542B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB2116542A (en) | 1983-09-28 |
JPS55153769A (en) | 1980-11-29 |
FR2456733A1 (en) | 1980-12-12 |
BE883320A (en) | 1980-11-14 |
IT1133009B (en) | 1986-07-09 |
GB2048863B (en) | 1983-06-15 |
GB2048863A (en) | 1980-12-17 |
FR2456733B1 (en) | 1983-08-26 |
NL8002828A (en) | 1980-11-18 |
DE3018545A1 (en) | 1980-11-27 |
IT8048675A0 (en) | 1980-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE20 | Patent expired after termination of 20 years |
Effective date: 20000414 |