GB2097397B - Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace - Google Patents

Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace

Info

Publication number
GB2097397B
GB2097397B GB8212490A GB8212490A GB2097397B GB 2097397 B GB2097397 B GB 2097397B GB 8212490 A GB8212490 A GB 8212490A GB 8212490 A GB8212490 A GB 8212490A GB 2097397 B GB2097397 B GB 2097397B
Authority
GB
United Kingdom
Prior art keywords
pharmace
aminocyclopentanol
esters
acids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8212490A
Other languages
English (en)
Other versions
GB2097397A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB8212490A priority Critical patent/GB2097397B/en
Publication of GB2097397A publication Critical patent/GB2097397A/en
Application granted granted Critical
Publication of GB2097397B publication Critical patent/GB2097397B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
GB8212490A 1981-04-29 1982-04-29 Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace Expired GB2097397B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8212490A GB2097397B (en) 1981-04-29 1982-04-29 Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8113238 1981-04-29
GB8212490A GB2097397B (en) 1981-04-29 1982-04-29 Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace

Publications (2)

Publication Number Publication Date
GB2097397A GB2097397A (en) 1982-11-03
GB2097397B true GB2097397B (en) 1984-09-19

Family

ID=10521483

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8212490A Expired GB2097397B (en) 1981-04-29 1982-04-29 Aminocyclopentanol acids and esters as prostaglandin analogues and their preparation and pharmace

Country Status (4)

Country Link
JP (1) JPS57183772A (ko)
DO (1) DOP1990004772A (ko)
GB (1) GB2097397B (ko)
ZA (1) ZA822933B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973576A (ja) * 1982-09-16 1984-04-25 グラクソ・グル−プ・リミテツド ピペリジニルシクロペンタノ−ルヘプテン酸塩
GB2127406B (en) * 1982-09-16 1986-03-05 Glaxo Group Ltd Piperidinlycyclopentanolheptenoic acid salt
AU576476B2 (en) * 1982-09-16 1988-09-01 Glaxo Group Limited Piperidinylcyclopentanol heptenoic acid salt
ES526813A0 (es) * 1982-10-28 1985-04-16 Glaxo Group Ltd Un procedimiento para preparar acidos de aminociclopentano
GB8307099D0 (en) * 1983-03-15 1983-04-20 Glaxo Group Ltd Carbocyclic compounds
US4613597A (en) * 1983-09-06 1986-09-23 Glaxo Group Limited Aminocyclopentanes and their preparation and pharmaceutical formulation
GB8601985D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Chemical process
US4968703A (en) * 1986-08-08 1990-11-06 Glaxo Group Limited Pharmaceutical compositions for the treatment of occlusive vascular diseases
GB8715333D0 (en) * 1987-06-30 1987-08-05 Glaxo Group Ltd Process
SE502288C2 (sv) * 1987-12-22 1995-09-25 Glaxo Group Ltd Vattenhaltig komposition innehållande ett piperidinylcyklopentylheptenonsyraderivat
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin
GB8811311D0 (en) * 1988-05-12 1988-06-15 Glaxo Group Ltd Medicaments
GB8814725D0 (en) * 1988-06-21 1988-07-27 Glaxo Group Ltd Medicaments

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7905375A (nl) * 1978-07-11 1980-01-15 Glaxo Group Ltd Prostanoiden, werkwijze voor het bereiden daarvan, en daarop gebaseerde farmaceutische preparaten.
ZA81114B (en) * 1980-01-09 1982-01-27 Glaxo Group Ltd Prostanoid compounds and their preparation and pharmaceutical formalation

Also Published As

Publication number Publication date
JPS57183772A (en) 1982-11-12
DOP1990004772A (es) 1996-02-02
GB2097397A (en) 1982-11-03
ZA822933B (en) 1983-04-27
JPH0352456B2 (ko) 1991-08-12

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19970429