GB2090133A - Veterinary Composition containing Vitamin E and Selenium Compounds - Google Patents

Veterinary Composition containing Vitamin E and Selenium Compounds Download PDF

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Publication number
GB2090133A
GB2090133A GB8036308A GB8036308A GB2090133A GB 2090133 A GB2090133 A GB 2090133A GB 8036308 A GB8036308 A GB 8036308A GB 8036308 A GB8036308 A GB 8036308A GB 2090133 A GB2090133 A GB 2090133A
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United Kingdom
Prior art keywords
vitamin
selenium
supplement
acid
horses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8036308A
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PATTERSON JANICE ANNE
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PATTERSON JANICE ANNE
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Filing date
Publication date
Application filed by PATTERSON JANICE ANNE filed Critical PATTERSON JANICE ANNE
Priority to GB8036308A priority Critical patent/GB2090133A/en
Publication of GB2090133A publication Critical patent/GB2090133A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An equine dietary supplement comprises an admixture of selenium which may be present as a metal selenide or thio-selenide with vitamin E, for the purpose of preventing muscle cramps in for example race horses. The supplement may be administered with a nutrient excipient which is an amino acid such as diamino caproic acid and as Lysine in a horse's dry feed. An example is given wherein other nutrients, vitamins and trace elements are also present. It is intended that the selenium should promote production of the enzyme glutathione peroxidase in the body thereby enabling the vitamin E to be utilised effectively.

Description

SPECIFICATION Improvements in and Relating to an Equine Dietary Medicament This invention relates to an equine dietary supplement for the purpose of avoiding sub clinical azoturia apparent in the occurrence of mild and low grade muscle cramps which not infrequently are suffered by race horses, causing them to 'fade' losing pace and or acceleration towards the end of a race.
In considering causology and preventative measures we have found that such symptoms may be alleviated by ingestion of vitamin E and our tests have shown that not only the vitamin but an enzyme, hereinafter called glutathione peroxidase, is necessary for vitamin E to function properly in achieving such muscle tone. The element selenium chemically analagous to sulphur and tellurium is an integral part of the molecule of glutathione peroxidase and it is believed that a dietary deficiency in selenium inhibits production of the aforesaid enzyme with consequent loss in efficiency of utilisation of vitamin E in maintaining muscle tone.
According to the invention, a dietary supplement comprises in combination selenium and vitamin E. The selenium and vitamin may be included in a high concentration vitamin mineral and amino acid supplement containing other trace elements and vitamins. The selenium may be present in the form of a metal selenide or thioselenide.
It is preferred to administer the supplement orally, i.e. with feed, rather than by injections since while good results, have been obtained by injections, a small proportion of horses reacted locally to the injection.
In trials, good results have been obtained, with the symptoms of sub clinical azoturia being reduced or absent and it is notable that in the course of trials, over 100 races have been won by horses being treated with the dietary supplement according to the invention, in particular they have not shown tendancies to fade with loss of speed and acceleration in the closing stages of a race and all finished well without exhibiting any distressing side-effects.
Analysis of normal untreated feeding stuffs for horses, namely hay, corn and live pasture grass has shown that most have very little or no selenium content, even the required trace amounts being deficient or absent, so that selenium deficiency giving rise to deficiency in the enzyme mentioned above and thus poor vitamin E utilisation is bound to occur. This clearly demonstrates a need for the dietary supplement according to the invention. Ingredients compatible in admixture fall into three main groups whereof two vitamins, undergo the synergistic recombination alluded to trace elements and amino acids ad excip, the second group including selenium, iodine and metals of Groups 2, 3 and 4A of the Periodic Table and the first group vitamins A, D and E.
Diamino caproic acid NH2 CH2: CH2: 3CH: NH2: COOH generally available as Lysine and Lomdognes having 4 to 20 carbon atoms in the molecular chain may be employed as nutrient excipient.
A supplement according to the invention wherein the quantities are in parts by weight except where stated in international units, i.u. is now set out by way of example: Ingedient quantity Vitamin A 50,000 i.u.
Vitamin D3 10,000 i.u.
Vitamin E 2,000 i.u.
Vitamin K 15 Vitamin B12 30 Vitamin B2 90 Folic Acid 60 Nicotinic Acid 1 50 Calcium Pantothenate 75 VitaminB1 113 Vitamin B6 60 Choline Chloride 900 Lysine ad 10,000 Selenium 68 Cobalt 8 lodine 1 5 Zinc 302 Manganese 225 Copper 75 Iron 300 The mixture is administered as a powder in 50 gram doses daily, the powder being mixed into horses solid feed such as ground maize.
Claims
1. As a composition of matter, a mixture comprising at least vitamin E and selenium.
2. The composition of claim 1 wherein the selenium is present in combination as a metal selenide.
3. The composition of claim 2 wherein the selenium is present in combination as a thioselenide.
4. A veterinary substance according to claim 4, wherein the vitamin E and a selenium compound are mixed with a nutrient excipient.
6. A veterinary substance according to claim 5 wherein the nutrient excipient is an amino acid.
7. A veterinary substance according to claim 6 wherein the nutrient excipient is an aliphatic diamino organic acid having from four to twenty atoms in the molecular chain.
8. A veterinary substance according to claim 7 wherein the acid is diamino caproic acid as Lysine or Lomognes.
9. A veterinary substance according to any one of the claims 4 to 8, further including further vitamins, metalic trace elements and nutrients.
10. A veterinary substance according to claim 9 as set out in the specific example hereinbefore.
11. An equine feed supplement including a
**WARNING** end of DESC field may overlap start of CLMS **.

Claims (1)

  1. **WARNING** start of CLMS field may overlap end of DESC **.
    SPECIFICATION Improvements in and Relating to an Equine Dietary Medicament This invention relates to an equine dietary supplement for the purpose of avoiding sub clinical azoturia apparent in the occurrence of mild and low grade muscle cramps which not infrequently are suffered by race horses, causing them to 'fade' losing pace and or acceleration towards the end of a race.
    In considering causology and preventative measures we have found that such symptoms may be alleviated by ingestion of vitamin E and our tests have shown that not only the vitamin but an enzyme, hereinafter called glutathione peroxidase, is necessary for vitamin E to function properly in achieving such muscle tone. The element selenium chemically analagous to sulphur and tellurium is an integral part of the molecule of glutathione peroxidase and it is believed that a dietary deficiency in selenium inhibits production of the aforesaid enzyme with consequent loss in efficiency of utilisation of vitamin E in maintaining muscle tone.
    According to the invention, a dietary supplement comprises in combination selenium and vitamin E. The selenium and vitamin may be included in a high concentration vitamin mineral and amino acid supplement containing other trace elements and vitamins. The selenium may be present in the form of a metal selenide or thioselenide.
    It is preferred to administer the supplement orally, i.e. with feed, rather than by injections since while good results, have been obtained by injections, a small proportion of horses reacted locally to the injection.
    In trials, good results have been obtained, with the symptoms of sub clinical azoturia being reduced or absent and it is notable that in the course of trials, over 100 races have been won by horses being treated with the dietary supplement according to the invention, in particular they have not shown tendancies to fade with loss of speed and acceleration in the closing stages of a race and all finished well without exhibiting any distressing side-effects.
    Analysis of normal untreated feeding stuffs for horses, namely hay, corn and live pasture grass has shown that most have very little or no selenium content, even the required trace amounts being deficient or absent, so that selenium deficiency giving rise to deficiency in the enzyme mentioned above and thus poor vitamin E utilisation is bound to occur. This clearly demonstrates a need for the dietary supplement according to the invention. Ingredients compatible in admixture fall into three main groups whereof two vitamins, undergo the synergistic recombination alluded to trace elements and amino acids ad excip, the second group including selenium, iodine and metals of Groups 2, 3 and 4A of the Periodic Table and the first group vitamins A, D and E.
    Diamino caproic acid NH2 CH2: CH2: 3CH: NH2: COOH generally available as Lysine and Lomdognes having 4 to 20 carbon atoms in the molecular chain may be employed as nutrient excipient.
    A supplement according to the invention wherein the quantities are in parts by weight except where stated in international units, i.u. is now set out by way of example: Ingedient quantity Vitamin A 50,000 i.u.
    Vitamin D3 10,000 i.u.
    Vitamin E 2,000 i.u.
    Vitamin K 15 Vitamin B12 30 Vitamin B2 90 Folic Acid 60 Nicotinic Acid 1 50 Calcium Pantothenate 75 VitaminB1 113 Vitamin B6 60 Choline Chloride 900 Lysine ad 10,000 Selenium 68 Cobalt 8 lodine 1 5 Zinc 302 Manganese 225 Copper 75 Iron 300 The mixture is administered as a powder in 50 gram doses daily, the powder being mixed into horses solid feed such as ground maize.
    Claims
    1. As a composition of matter, a mixture comprising at least vitamin E and selenium.
    2. The composition of claim 1 wherein the selenium is present in combination as a metal selenide.
    3. The composition of claim 2 wherein the selenium is present in combination as a thioselenide.
    4. A veterinary substance according to claim 4, wherein the vitamin E and a selenium compound are mixed with a nutrient excipient.
    6. A veterinary substance according to claim 5 wherein the nutrient excipient is an amino acid.
    7. A veterinary substance according to claim 6 wherein the nutrient excipient is an aliphatic diamino organic acid having from four to twenty atoms in the molecular chain.
    8. A veterinary substance according to claim 7 wherein the acid is diamino caproic acid as Lysine or Lomognes.
    9. A veterinary substance according to any one of the claims 4 to 8, further including further vitamins, metalic trace elements and nutrients.
    10. A veterinary substance according to claim 9 as set out in the specific example hereinbefore.
    11. An equine feed supplement including a composition according to claim 1, 2, or 3, or a veterinary substance according to any one of claims 4 to 10.
    12. An equine feed mixture including, in a solid feed, a composition substance or supplement according to any one of the preceeding claims.
GB8036308A 1980-11-12 1980-11-12 Veterinary Composition containing Vitamin E and Selenium Compounds Withdrawn GB2090133A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8036308A GB2090133A (en) 1980-11-12 1980-11-12 Veterinary Composition containing Vitamin E and Selenium Compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8036308A GB2090133A (en) 1980-11-12 1980-11-12 Veterinary Composition containing Vitamin E and Selenium Compounds

Publications (1)

Publication Number Publication Date
GB2090133A true GB2090133A (en) 1982-07-07

Family

ID=10517254

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8036308A Withdrawn GB2090133A (en) 1980-11-12 1980-11-12 Veterinary Composition containing Vitamin E and Selenium Compounds

Country Status (1)

Country Link
GB (1) GB2090133A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091762A1 (en) * 1982-04-07 1983-10-19 Orion-yhtymä Oy Process for the production of an iron-selenium trace element solution
AT394493B (en) * 1989-05-11 1992-04-10 Homosan Ag PHARMACEUTICAL PREPARATION FOR TREATING LIVER DISEASES

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091762A1 (en) * 1982-04-07 1983-10-19 Orion-yhtymä Oy Process for the production of an iron-selenium trace element solution
AT394493B (en) * 1989-05-11 1992-04-10 Homosan Ag PHARMACEUTICAL PREPARATION FOR TREATING LIVER DISEASES

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