GB2081089A - Method of preparing a ginseng injection - Google Patents
Method of preparing a ginseng injection Download PDFInfo
- Publication number
- GB2081089A GB2081089A GB8114627A GB8114627A GB2081089A GB 2081089 A GB2081089 A GB 2081089A GB 8114627 A GB8114627 A GB 8114627A GB 8114627 A GB8114627 A GB 8114627A GB 2081089 A GB2081089 A GB 2081089A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ginseng
- injection
- gonadotrophin
- extract
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A method of preparing a ginseng injection from ginseng roots comprising the steps of making a highly concentrated extract of ginseng roots and adding a quantity of gonadotrophin to the extract. A ginseng injection thus prepared is easily absorbed into the human or animal body. The ginseng injection according to the invention thus provides a means of administering ginseng by injection which avoids the unwanted side effects normally associated with the injection of ginseng extract.
Description
SPECIFICATION
Method of preparing a ginseng injection
This invention relates to a method of preparing a ginseng injection.
The use of the ginseng root or extracts thereof as a medicinal panacea is well known. In the past ginseng has only been administered orally. Medicines and pharmaceuticals are often considerably more effective though when administered by injection. In this case not only is any medicinal effect likely to occur more quickly but the amount of the medicine required to achieve the same effect as is obtained by oral administration is often less. As ginseng is expensive and rapid medical results highly desirable there are considerable advantages to be gained in preparing ginseng for administration by injection.
Hitherto the administration of ginseng by injection has been hindered by the fact that pure ginseng or ginseng extract administered by injection is not easily absorbed into the human body. Previous attempts to produce preparations of ginseng for injection have thus been unsuccessful and use of such preparations is accompanied by unwanted side effects.
According to the present invention there is provided a method of preparing a ginseng injection comprising preparing an extract of ginseng roots and adding a quantity of gonadotrophin to said extract.
The present invention provides a ginseng extract which may be administered by injection and yet still be easily absorbed by the human body without the side effects normally associated with the injection of ginseng extract. Clinical trials have shown that the presence of the gonadotrophin does not appear to have any undesired side effects and furthermore appears to produce a synergistic effect with the ginseng extract. The theoretical basis of the invention has not been established. However, the present invention has the advantage that it renders possible the administration of highly concentrated ginseng extract without apparently incurring any unwanted side effects. The gonadotrophin used preferably comprises a human placental gonadotrophin such as human chorionic gonadotrophin.
An embodiment of the present invention will now be described by way of example with reference to the accompanying examples and tables.
Roots of undried ginseng plants preferably between 5 and 6 years old are first heated using steam to a temperature preferably between 60 to 1000C at which temperature they are kept for a period of time preferably from 2 to 5 hours. More preferably a low heating temperature preferably 70"C should be used to avoid destruction of the active ingredients of the ginseng.
The roots are then dried in the sun for a day and the process repeated three times so as to obtain purified ginseng roots which resemble steamed and dried red ginseng roots.
600 grams of the purified ginseng thus obtained is then immersed in 3 litres of distilled water and 1 litre of the water evaporated by heating. The resulting solution is then cooled and stored in a cool dark place, preferably for between 24 and 36 hours. The solution is then filtered preferably using a No. 19 filter paper and a centrifuge operating at 3000 r.p.m.
for twenty minutes. The filtered solution thus obtained comprises a highly concentrated extract of ginseng.
Gonadotrophin in an amount preferably between 2-7 mg. per 2 ml. is then added to the above obtained extract and the solution stirred well and stored in a dark place preferably for between 2448 hours. Having thus obtained a homogenous stabilized solution, asbestos and bacteriological filtration of the solution are carried out. When adding the gonadotrophin to the ginseng extract other nutrients and/or antiseptics may be added simultaneously as desired.
The resulting solution may then be used as a ginseng injection in accordance with the Korean Pharmacoepia in measures preferably of 2 ml. per unit. A unit measure of a ginseng injection prepared according to the preferred embodiment of the present invention described above would be comprised as follows:
Concentrated ginseng extract (containing the extract of 600 mg of ginseng) 2 ml
Gonadotrophin 5 mg
Edible Salt 0.018 mg
Carbolic acid (antiseptic) 0.01 ml
Preferably 20 ml of the ginseng injection according to the present invention is administered daily or every other day by subcutaneous or intramuscular injection. Such use has been shown to be effective in treating a number of medical conditions as is shown by the results of clinical trials shown in tables 1 and 2.The ginseng injection according to the present invention has been used to treat general debility, symptoms of senility, pernicious anaemia, adynamia, neuralgia, hepatitis, poor constitution and/or appetite and other conditions.
Table 1
Name ofdisease Total number % ofsamples Numberofexamples treated Effective Some effect No effect of examples showing an effect showing an effect Degenerative arthritis 4 2 6 66.6 4 Genu arthritis and coxitis 2 4 1 7 85.7 6 16 81.2 13 Rheumatoid arthritis 10 3 3 16 81.2 13 (Supplied by the Orthopedy of the Medicinal College, the Choongnam University, Korea)
Table2
Numberof examples Numberof %of examples examples Name ofdisease Optimum Total number showing an showing an treated effect Effective Some effect No effect of examples effect effect Cerebral hemorrhage sequelae 3 3 100 3 Cerebral thrombosis sequelae 2 2 100 2 Cerebral trauma sequelae 1 1 6 8 100 8 7 Hypertensive cerebral diseases 1 1 100 1 Headache 5 1 6 83 5 Epilepsy 2 4 6 33 2 Parkinson's syndrome (disease) 1 1 0 0 Insomnia 1 1 100 1 Spinal syphilis 1 1 0 0 Spinal trauma sequelae 1 1 100 1 Neurosis 4 4 100 4 Spinitis 1 1 0 0 {Supplied by the Neurological Dept., The National Medical Center, Korea)
The following tests were also carried out to show the effectiveness of the present invention in enabling rapid absorption of ginseng administered by injection.
Test example 1
1 ml portions of a highly concentrated ginseng extract of pH between 6.00 and 7.00 were prepared in the manner described above but without the addition of gonadotrophin (each 1 ml contained the extract of 300 mg of ginseng root) for use in forming control injections.
3 ml of the above extract was administered to the' hips of a dog (weight 13 kg) and a rabbit (weight3 kg) by subcutaneous injection once a day. Such administration was repeated five times, observations conceming the absorbability of the injected ginseng extract thus being carried out continuously for five (5) days. It was found thatthe ginseng injec tion was not absorbed by the test dog or rabbit, and that a lump formed by the unabsorbed injection appeared on the injected portion of the test animal.
Mild rubbing of the lumps by hand for 30 minutes each day for about six (6) days, resulted in the disappearance of the lump and after three days, the test dog and rabbit had recovered their normal eating, sleeping and motion habits.
Test example 2
An injection solution made from 2 ml amounts of highly concentrated ginseng extract prepared according to the present invention each containing the extract of 600 mg of ginseng root and 5 mg of gonadotrophin was administered to the hips of a dog and a rabbit having the same body weights as in the above Example 1 by the subcutaneous injection of 3 ml of the above solution once a day. It was found that the injection was completely absorbed into the test animals within one hour of the injection time, and that there were no changes observed in the eating, sleeping or motion behaviour of the animals as compared with their behaviour prior to injection.
From the above clinical demonstrations and the above test results, it has been shown that the ginseng injection according to the present invention may be quickly absorbed into the human or animal body without any side effects. More particularly, the gonadotrophin used, according to the present invention is intimately mixed with the ginseng extract, and is quickly absorbed into the human body without any side effects as a result of its own high permeating power in the human body. Furthermore, a synergistic effect over and above the effect of the gonadotrophin and the effect of the ginseng may be obtainable.
Claims (11)
1. A ginseng injection comprising an extract of ginseng roots and a quantity of gonadotrophin.
2. An injection according to claim 1 wherein said gonadotrophin is a human placental gonadotrophin.
3. An injection according to claim 1 or claim 2 further comprising an antiseptic.
4. A method of preparing a ginseng injection comprising the steps of:
(a) heating ginseng roots with steam and then drying them,
(b) immersing said dried ginseng roots in water and heating said water to evaporate a part of it and subsequently cooling the resultant solution,
(c) storing said resultant solution in the dark and then filtering said solution,
(d) adding a quantity of gonadotrophin to said filtered solution.
5. A method according to claim 4 wherein step (a) is performed more than once before step (b).
6. A method according to claim 4 or claim 5 wherein the ratio of said dried ginseng roots to said water is 600 g ginseng root per 3000 ml water.
7. A method according to any one of claims 4 to 6 wherein said ratio of said gonadotrophin to said filtered solution is from 2 to 7 mg gonadotrophin per 2 ml filtered solution.
8. A method according to claim 7 wherein said ratio of gonadotrophin to said filtered solution is 5 mg gonadotrophin per 2 ml filtered solution.
9. A method according to any one of claims 4 to 8 wherein said solution resulting from step (b) is stored for between 24 and 36 hours.
10. A ginseng injection according to claim 1 substantially as described herein.
11. A method of producing a ginseng injection substantially as described herein.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019800003107A KR810001952B1 (en) | 1980-08-05 | 1980-08-05 | Process for preparing infusion of ginseng |
Publications (1)
Publication Number | Publication Date |
---|---|
GB2081089A true GB2081089A (en) | 1982-02-17 |
Family
ID=19217351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8114627A Withdrawn GB2081089A (en) | 1980-08-05 | 1981-05-13 | Method of preparing a ginseng injection |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS5732214A (en) |
KR (1) | KR810001952B1 (en) |
GB (1) | GB2081089A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2532179A1 (en) * | 1982-08-25 | 1984-03-02 | Tsumura Juntendo Kk | PHARMACEUTICAL PREPARATION TO IMPROVE THE SYMPTOMS OF CANCER |
US6010702A (en) * | 1998-05-14 | 2000-01-04 | Geong Mok Lee | Herbal drug composition for the prevention and treatment of dementia |
-
1980
- 1980-08-05 KR KR1019800003107A patent/KR810001952B1/en active
-
1981
- 1981-04-04 JP JP5006881A patent/JPS5732214A/en active Pending
- 1981-05-13 GB GB8114627A patent/GB2081089A/en not_active Withdrawn
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2532179A1 (en) * | 1982-08-25 | 1984-03-02 | Tsumura Juntendo Kk | PHARMACEUTICAL PREPARATION TO IMPROVE THE SYMPTOMS OF CANCER |
GB2126084A (en) * | 1982-08-25 | 1984-03-21 | Tsumura Juntendo Kk | Composition for mitigating the side-effects of anti-cancer agents |
US6010702A (en) * | 1998-05-14 | 2000-01-04 | Geong Mok Lee | Herbal drug composition for the prevention and treatment of dementia |
Also Published As
Publication number | Publication date |
---|---|
KR810001952B1 (en) | 1981-12-01 |
JPS5732214A (en) | 1982-02-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |