GB2073194A - 2,4-diaryl Thiazol-5-yl-acetic Acids - Google Patents
2,4-diaryl Thiazol-5-yl-acetic Acids Download PDFInfo
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- GB2073194A GB2073194A GB8110363A GB8110363A GB2073194A GB 2073194 A GB2073194 A GB 2073194A GB 8110363 A GB8110363 A GB 8110363A GB 8110363 A GB8110363 A GB 8110363A GB 2073194 A GB2073194 A GB 2073194A
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- United Kingdom
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- formula
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- chlorophenyl
- acetic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Thiazoles of formula <IMAGE> and salts thereof, wherein R represents hydrogen or an acyl group, possess anti-inflammatory activity and have low toxicity. The compounds may be formulated as pharmaceutical compositions.
Description
SPECIFICATION
Thiazoles
This invention relates to thiazoles, possessing pharmaceutical activity, to processes for preparing them, to pharmaceutical composition containing them, and to methods of using them.
In our UK Patent Specification No. 1,145,884 there are described and claimed compounds of the general formula (A)
and acid addition salts thereof, in which R1 and R2 are the same or different and are substituted aryl radicals (which may be heteroaryl radicals) and R3 is a lower aliphatic carboxylic acid radical containing from 2 to 6 carbon atoms or a salt, ester, amide, nitrile or hydroxamic acid derivative thereof, said radical R3 being attached to the thiazole ring by a carbon atom on the aliphatic chain.
According to UK Patent Specification No. 1,145,884 the compounds of formula A possess pharmacological activity particularly anti-inflammatory activity. Examples of R' and R2 are unsubstituted phenyl and phenyl substituted by halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino, mercapto, alkylthio, alkylsulphonyl, or trihalomethyl.
The anti-inflammatory activity of specific compounds of formula A against carrageenin-induced edema in the rat hind paw was extensively reported by Brown et al, in Journal of Medicinal Chemistry, 1974, Vol. 17 No. 1 pps. 1177 to 1181. Structure activity relationship revealed that the antiinflammatory activity was found to be optimised when R2 was 4-chlorophenyl. However, the preferred
R1 group was found to be phenyl and 4-substitution of this ring reduced the anti-inflammatory activity.
Thus 4-methoxy and 4-carboxy substitution both substantially reduced activity when R2 was 4chlorophenyl.
We have now surprisingly found a series of thiazole-5-acetic acids not specifically mentioned in the general formula (A) wherein R' represents a 4-substituted-phenyl, which possess marked anti- inflammatory activity, especially when administered topically. Furthermore this series of thiazole-5acetic acids possess low toxicity.
Accordingly this invention provides a compound having the formula:
and salts thereof wherein R represents hydrogen or an acyl group, e.g. an alkanoyl group having 2 to 7 carbon atoms, preferably 2 to 5 carbon atoms. Examples of R are acetyl, propionyl, butyryl, isobutyryl, valeryl and isovaleryl.
The compounds of formula I form salts, for example acid addition salts with acids such as hydrochloric and hydrobromic acid, or alkali metal (e.g. sodium or potassium) or alkaiine earth metal (e.g. calcium) salts. Such salts may be prepared in known manner.
Compounds of formula I were tested for anti-inflammatory activity by the following procedure based on Tonelli et al, Endocrinology 77, 625 (1965):
Sprague-Dawley female rats, weighing 60 to 70 grams, are used in groups of 10. Ear edema is induced by inuncting both sides of the ear with an irritant mixture. This mixture containing 1% croton oil, 20% pyridine, 5% water and 74% diethyl ether, with or without test compound, is applied only once and only to the right ear. Six hours later the animals are sacrificed; a 9 mm diameter portion of both ears is punched out with a cork borer and weighed. The anti-inflammatory activity of the test agent is assessed by expressing the percent of the difference in average weight increase between the ears of the control groups and of the treated group.
Results found for representative compounds of formula I are tabulated below, together with results found in 3 tests for the preferred compound reported by Brown et al in J. Med. Chem. (loc-cit) namely 4-(p-chlorophenyl)-2-phenyl- thiazol e-5-acetic acid (B): Compound of formula I Dose % Inhibition
R=H 50 g 16%
500 g 33%
2.5 mg 86%
5 mg 92% R=COCH3 50 g -14%
500 g 41%
2.5 mg 85%
5 mg 100% R=COC4Hg 50,ug 41%
500 g 54% 2.5 mg 71%
5 mg 87% 50 g 30,15-7% 500,ug 10,35,52% 2.5 mg 93, 79, 89%
5 mg 92,93,93%
The compounds all show marked anti-inflammatory activity of about the same order.
Toxicity of compounds of formula I was measured by administering test compound orally to groups of 3 male and 3 femaie non-starved TFW mice at a series of dose levels. The results obtained for the compound of formula I (R=H) and the preferred compound of formula B from J. Med. Chem.
(loc-cit) are shown in the Table below:
No. Dead (hours from dosing)
Dose level Formula I (R=H) Formula B mg/kg 24 hours 7days 24 hours 7 days
450 0 0 2 3
675 1 1 3 6
1012.5 1 1 3 6
1518.8 1 1 2 4
2278.1 0 0 3 3
3417.2 0 0 5 6 These results show the compou nd compound 4-(p-chiorophenyl)-2-(p-hydroxyphenyl)thiazole-5-acetic acid to be considerably less toxic than the corresponding 2-phenyl analogue (Formula B).
This invention also provides processes for preparing compounds of formula I. Such processes are outlined in U.K. Patent Specification Nos. 1,145,884 and U.K. Patent 1,262,292. Accordingly this invention provides a process for preparing a compound of formula I or an acid addition salt thereof
which comprises:
(a) reacting an a-haloketone of general formula: p-chlorophenyl-CO-CHCH,COOH (II)
hal wherein hal is a halogen atom, with a thioamide of general formula:
wherein R is as hereinbefore defined, or
(b) dehydrating a compound of formula
wherein R is as hereinbefore defined to give a corresponding compound of formula I, or
(c) acylating a compound of formula I wherein R is hydrogen to give a compound of formula I wherein R is an acyl group, or
(d) dealkylating a compound of formula::
wherein R4 is alkyl or aralkyl, to give a compound of formula I wherein R is hydrogen, or
(e) hydrolysing a mono- or di-ester of formula:
wherein R is as hereinbefore defined and R5 is H or an alkyl or aralkyl group with the proviso that R and
R5 are not both hydrogen.
Methods for carrying out processes (a) and (b) above are extensively described in our U.K. Patent
Specification Nos. 1,145,882 and 1,262,292.
Acylation of a compound of formula I wherein R is hydrogen may be effected by standard methods using an acylating agent comprising an acyl R moiety, such as an anhydride or acyl halide e.g.
chloride.
Methods for carrying out dealkylation in process step (d) are well known in the art, for example treating the ethers with hydrogen bromide, hydrogen iodide or boron tribromide. Preferably R4 is alkyl of 1 to 4 carbon atoms, most preferably methyl.
Hydrolysis of compounds of formula (VI) may be carried out in known manner, e.g. using an alkali metal hydroxide and acidifying.
The invention provides a pharmaceutical composition comprising a compound of general formula
(I) or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier. Any suitable carrier known in the art can be used to prepare the pharmaceutical composition. In such a composition, the carrier is generally a solid or liquid, or a mixture of a solid and a liquid. In some aerosol composition the carrier may be a gas.
Solid form compositions include powders, granules, tablets, capsules (e.g. hard and soft gelatin
capsules), suppositaries and pessaries. A solid carrier can be, for example, one or more substances zilch may also act as flavouring agents, lubricants, solubilisers, suspending agents, fillers, glidants,
compression aids, binders or tablet-disintegrating agents; it can also be an encapsulating material. In
powders the carrier is a finely divided solid which is in admixture with the finely divided active
ingredient. In tablets the active ingredient is mixed with a carrier having the necessary compression properties in suitable proportions and compacted in the shape and size desired.The powders and tablets preferably contain up to 99%, e.g. from 0.03 to 99%, preferably 1 to 80% of the active ingredient Suitable solid carriers include, for example, calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, methyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidine, low melting waxes and ion exchange resins.
The term "composition" is intended to include the formulation of an active ingredient with encapsulating material as carrier to give a capsule in which the active ingredient (with or without other carriers) is surrounded by the carrier, which is thus in association with it. Similarly cachets are included.
Liquid form compositions include, for example, solutions, suspensions, emulsions, syrups, elixirs
and pressurised compositions. The active ingredient, for example, can be dissolved or suspended in a
pharmaceutically acceptable liquid carrier such as water, an organic solvent, a mixture of both or
pharmaceutically acceptable oils and faxs. The liquid carrier can contain other suitable pharmaceutical
additives such as solubilizers, emulsifiers, buffers, preservatives, sweeteners, flavouring agents, suspending agents, thickening agents, colours, viscosity regulators, stabilisers or osmo-regulators.
Suitable examples of liquid carriers for oral and parenteral administration include water (particularly
containing additives as above e.g. cellulose derivatives, preferably sodium carboxymethyi cellulose
solution), alcohols (including monohydric aldohols and polyhydric alcohols e.g. glycerol and glycols) and their derivatives, and oils (e.g. fractionated coconut oil and arachis oil). For parental administration the
carrier can also be an oily ester such as ethyl oleate and isopropyl myristate. Sterile liquid carriers are
used in sterile liquid form compositions for parental administration. The liquid carrier for pressurised
compositions can be a halogenated hydrocarbon or other pharmaceutically acceptable propellent.
Liquid pharmaceutical compositions which are sterile solutions or suspensions can be utilised by, for example, intramuscular, intraperitoneal or subcutaneous injection. Sterile solutions can also be
administered intraveously. When the compound is orally active it can be administered orally either in
liquid or solid composition form.
Preferably the pharmaceutical composition is in unit dosage form, e.g. as tablets or capsules. In
such form, the composition is sub-divided in unit dose containing appropriate quantities of the active
ingredient; the unit dosage forms can be packaged compositions, for example packeted powders, vials,
ampoules, prefilled syringes or sachets containing liquids. The unit dosage form can be, for example, a
capsule or tablet itself, or it can be the appropriate number of any such compositions in package form.
The quantity of the active ingredient in a unit dose of composition may be varied or adjusted from
0.5mg. or less to 750mg. or more, according to the particular need and the activity of the active
ingredient. The invention also includes the compounds in the absence of the carrier where the compounds are in unit dosage form.
The present invention also provides a semi-solid or aerosol pharmaceutical composition for topical administration comprising a compound of formula I or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable topical carrier.
By a 'semi-solid pharmaceutical composition' is meant an ointment, cream, salve, paste, jelly or other pharmaceutically or cosmetic composition of substantially similar consistency suitable for
application to the skin. Examples of semi-solid compositions are given in Chapter 17 of The Theory and
Practice of Industrial Pharmacy, Lachman, Lieberman and Kanig, published by Lea and Febiger (1970)
and in Chapter 67 of Remington's Pharmaceutical Sciences, 15th Edition (1975) published by Mack
Publishing Company.
Preferably, the topical compositions of the present invention contain from about 0.1% to about 20% by weight of the active ingredient. The compositions may, for example, contain from about 0.5% (preferably from about 1%) to about 10% by weight of the active ingredient.
The carrier used in the topical compositions of the present invention may be any carrier suitable for preparing topical semi-solid compositions or topical aerosol compositions. Examples of suitable carriers for semi-solid compositions are given in Lachman, Lieberman and Kanig (loc-cit) and in Chapter 67 of Remington's Pharmaceutical Sciences, (loc-cit). The carrier for the semi-solid composition may be, for example an emulsion base of the oil in water class (e.g. an emulsion of soft and liquid paraffins in water). Alternatively, the carrier may be an absorption base (e.g. a mixture of wool fat and soft paraffin). A third class of suitable carriers are water miscible bases (e.g. mixtures of high and low molecular weight polythene glycols).
When the composition is in aerosol form for topical administration, the composition may comprise the active ingredient and an easily liquifiable gas. Examples of such liquifiable gases are halogenated hydrocarbons and liquified lower hydrocarbons, both of which are well known as propellants in the aerosol art. (By "lower hydrocarbon" is meant a hydrocarbon containing up to six carbon atoms).
In addition to the active ingredient and the carrier base, the compositions of the invention may contain other ingredients such as antioxidants, buffers, emulsifying agents, perfumes, preservatives and solvents which confer on the product properties desirable in a topical formulation. In particular, buffers may be employed to adjust the pH of the composition to within the range of, for example 4 to 5.5 (e.g. 4.8) to maintain the active ingredient in its free acid form. The compositions can also contain other active ingredients.
In a further aspect, the invention provides a method of treating inflammation in warm blooded
non-human animals which comprises topically administering to the animal an anti-inflammatory
effective amount of a compound of formula I. By "topically administering" is meant administering to
the exterior skin surface. The active ingredient may be administered in the form of a composition of the
present invention.
Example 1 4-(4-Chlorophenyl )-2-(4-hydroxyphenyl)thiazole-5-acetic acid 4-(Chlorophenyl)-2-(4-methoxyphenyl)thiazole-5-acetic acid (1.26 g, 3.5 mmol) was heated to
reflux in a mixture of glacial acetic acid (10 cm3) and 48% hydrobromic acid (20 cm3) for 4 hours. On
cooling, the hydrobromide salt of the title compound crystallised (1.03 g). The crystals were collected,
washed with water and ether, and dried m.p. 239-241 0 (decomp).
Analysis:
Found: C, 47.7; H, 3.1; N, 2.4; ionic bromine 19.2.
Ca7H12CINO3S.HBrrequires: C, 47.8; H, 3.1; N, 3.3; ionic bromine 18.7%.
Example 2
4-(4-Chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5-acetic acid 3-Bromo-3-(4-chlorobenzoyl)propionic acid (27 g), and 4-hydroxy-thiobenzamide (14.6 g) were
heated to 800 in dimethylformamide (50 ml). The reactants were kept at this temperature for 1 hour,
cooled and poured onto ice. The resulting gum solidified, and was filtered, and washed with water, to
give 31.6 g of powder, m.p. 1 81 940C (decomp.). This was recrystallised from aqueous isopropanol
affording 25.4 g of the title compound, hemi-hydrate, m.p. 1 92--1940 (d).
Analysis:
Found: C, 57.7; H, 3.5; -N,3.6.
C,7H,2CINO3S.2H2O requires: C, 57.55; H, 3.7; N 3.9%.
Example 3 2-(4-Acetoxyphenyl)-4-(4-chlorophenyl Xthiazole-5-acetic acid 4-(4-Chlorophenyl)-2-(4-hydroxyphenyl)-thiazole-5-acetic acid (7.0 g, 0.016 moles) was
dissolved in 0.1 N sodium hydroxide (493 ml, 0.372 moles) and cooled to OOC. Acetic anhydride (1.5 ml, 0.016 moles) was added and the mixture left standing at room temperature for 3 hours. To the
solution was added dilute hydrochloric acid and the resulting precipitate was filtered off, washed with a
little water, dried and recrystallised from methylethylketone to give the title compound as a colourless
solid (2.4 gm), m.p. 177-1 800C.
Analysis:
Found: C, 58.94; H, 3.87; N, 3.43%.
C1gH14CINO4S requires: C, 58.84; H, 3.64; N, 3.61%.
Example 4 4-(4Chlorophenyl )-2-(4Valeryloxyphenyl)thiazole-5-acetic acid 4-[4-Chlorophenyl]-2-[4-hydroxyphenyl]-thiazole-5-acetic acid (3.81 g, 0.011 moles) was dissolved in 0.2 N sodium hydroxide (55 ml, 0.027 moles) and cooled to OOC. Valeryl anhydride (2.0 g,
0.011 moles) was added and the reaction flask shaken vigorously for 4 minutes. Dilute hydrochloric
acid was added, and the resulting gum extracted into chloroform. The chloroform layer was washed
with water, separated, dried over magnesium sulphate to give a white solid. The solid was stirred with
water at about 500C for 1/4 hour, filtered and dried to give the title compound as a colourless solid
(3.68 g), m.p. 1 97--9 OC.
Analysis:
Found: C, 61.16; H, 4.61; N, 3.11.
C22H20CINO4S requires: C, 61.46; H, 4.69; N, 3.26.
Example 5 m(4-Chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5-acetic acid
By a process analogous to Example 2, methyl-3-bromo-3-(4-chlorobenzoyl)propionate and 4hydroxy-thiobenzamide are reacted to give methyl 4-(4-chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5acetate. This compound is hydrolysed using 2N sodium hydroxide to give the title compound.
Example 6 4-(4-Chlorophenyl)-2-(4-hydroxphenyl)thiazole-5-acetic acid 2-(4-Acetoxyphenyl)-4-(4-chlorophenyl)-thiazole-5-acetic acid (prepared according to Example 3) is hydrolysed using 2N sodium hydroxide to give the title compound.
Example 7 4-(4-Chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5-acetic acid
3-Bromo-3-(4-chlorobenzoyl)propionate acid and an equimolar amount of 4-hydroxythiobenzamide are stirred in isopropyl alcohol solvent containing sodium carbonate to give 4-(4 chlorophenyl)-4-hydroxy-2-(4-hydroxyphenyl)-2-thiazolin-5-acetic acid. This compound is dehydrated by heating to give the title compound.
Claims (14)
1. A compound of formula
or a salt thereof, wherein R represents hydrogen or an acyl group.
2. A compound as claimed in Claim 1 wherein R represents alkanoyl of 2 to 7 carbon atoms.
3. 4-(4-chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5-acetic acid or a salt thereof.
4. 2-(4-acetoxyphenyl)-4-(4-chlorophenyl)th iazole-5-acetic acid or a salt thereof.
5. 4-(4-chlorophenyl)-2-(4-valeryloxyphenyl)thiazole- 5-acetic acid or a salt thereof.
6. A process for preparing a compound of formula
or a salt thereof, wherein R represents hydrogen or an acyl group, characterised in that:
(a) an a-haloketone of general formula:
wherein hal is a halogen atom, is reacted with a thioamide of general formula:
wherein R is as hereinbefore defined, or
(b) a compound of formula
wherein R is as hereinbefore defined is dehydrated to give a corresponding compound of formula I, or
(c) a compound of formula I wherein R is hydrogen is acylated to give a compound of formula I wherein R is an acyl group, or
(d) a compound of formula:
wherein R4 is alkyl or aralkyl, is dealkylated to give a compound of formula I wherein R is hydrogen, or
(e) a mono-ordi-esterofformula::
wherein R is as hereinbefore defined and R5 is H or an alkyl or aralkyl group with the proviso that R and
R5 are not both hydrogen, is hydrolysed, or
(f) a compound of formula I is converted to a salt thereof or a salt is converted to a compound of formula I.
7. A process (a) as claimed in Claim 6 wherein R represents alkanoyl of 2 to 7 carbon atoms.
8. A process (a) as claimed in Claim 6 wherein hal represent chlorine or bromine.
9. A process (d) as claimed in Claim 6 wherein R4 is alkyl of 1 to 4 carbon atoms.
10. A process for preparing a compound of formula I as defined in Claim 1 substantially as hereinbefore described with reference to any one of Examples 1 to 7.
11. A compound of formula I whenever prepared by a process as claimed in any one of Claims 6 to 10.
12. A compound of formula I as defined in Claim 1 for use as an anti-inflammatory agent.
13. A pharmaceutical composition comprising a compound of formula I as claimed in any one of
Claims 1 to 5 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
14. A pharmaceutical composition as claimed in Claim 13 which is in unit dosage form.
1 5. A pharmaceutical composition as claimed in Claim 13 which is in semi-solid or aerosol form for topical application.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8011251 | 1980-04-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2073194A true GB2073194A (en) | 1981-10-14 |
GB2073194B GB2073194B (en) | 1983-10-19 |
Family
ID=10512592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8110363A Expired GB2073194B (en) | 1980-04-03 | 1981-04-02 | 2,4-diaryl thiazol-5-yl acetic acids |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS56154472A (en) |
BE (1) | BE888252A (en) |
CS (1) | CS222694B2 (en) |
GB (1) | GB2073194B (en) |
HU (1) | HU185038B (en) |
SU (1) | SU1099844A3 (en) |
ZA (1) | ZA811691B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0431514U (en) * | 1990-07-03 | 1992-03-13 | ||
JPH04129502A (en) * | 1990-09-20 | 1992-04-30 | Morito Kk | Manufacture of slide fastener and device therefor |
DE69132944T2 (en) | 1990-11-30 | 2002-11-21 | Otsuka Pharmaceutical Co., Ltd. | Azole derivatives as inhibitors of superoxide radicals |
MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
JP4073786B2 (en) | 2001-04-16 | 2008-04-09 | 田辺三菱製薬株式会社 | High conductance calcium-sensitive K channel opener |
-
1981
- 1981-03-13 ZA ZA00811691A patent/ZA811691B/en unknown
- 1981-04-01 JP JP4999981A patent/JPS56154472A/en active Granted
- 1981-04-01 HU HU81843A patent/HU185038B/en unknown
- 1981-04-02 SU SU813264554A patent/SU1099844A3/en active
- 1981-04-02 BE BE0/204360A patent/BE888252A/en not_active IP Right Cessation
- 1981-04-02 GB GB8110363A patent/GB2073194B/en not_active Expired
- 1981-04-03 CS CS812525A patent/CS222694B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB2073194B (en) | 1983-10-19 |
CS222694B2 (en) | 1983-07-29 |
JPH0214328B2 (en) | 1990-04-06 |
SU1099844A3 (en) | 1984-06-23 |
JPS56154472A (en) | 1981-11-30 |
HU185038B (en) | 1984-11-28 |
BE888252A (en) | 1981-10-02 |
ZA811691B (en) | 1982-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
727 | Application made for amendment of specification (sect. 27/1977) | ||
727A | Application for amendment of specification now open to opposition (sect. 27/1977) | ||
727B | Case decided by the comptroller ** specification amended (sect. 27/1977) | ||
SP | Amendment (slips) printed | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 20010401 |