GB2049703B - Dipeptide preparation utilising an insolubilised-metalloproteinase - Google Patents
Dipeptide preparation utilising an insolubilised-metalloproteinaseInfo
- Publication number
- GB2049703B GB2049703B GB8011159A GB8011159A GB2049703B GB 2049703 B GB2049703 B GB 2049703B GB 8011159 A GB8011159 A GB 8011159A GB 8011159 A GB8011159 A GB 8011159A GB 2049703 B GB2049703 B GB 2049703B
- Authority
- GB
- United Kingdom
- Prior art keywords
- insolubilised
- metalloproteinase
- utilising
- dipeptide
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4017079A JPS55135595A (en) | 1979-04-03 | 1979-04-03 | Preparation of dipeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2049703A GB2049703A (en) | 1980-12-31 |
GB2049703B true GB2049703B (en) | 1983-01-12 |
Family
ID=12573284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8011159A Expired GB2049703B (en) | 1979-04-03 | 1980-04-02 | Dipeptide preparation utilising an insolubilised-metalloproteinase |
Country Status (10)
Country | Link |
---|---|
US (1) | US4284721A (en) |
JP (1) | JPS55135595A (en) |
BE (1) | BE882603A (en) |
CA (1) | CA1133841A (en) |
CH (1) | CH645341A5 (en) |
DE (1) | DE3012693A1 (en) |
FR (1) | FR2453137B1 (en) |
GB (1) | GB2049703B (en) |
IT (1) | IT1147338B (en) |
NL (1) | NL8001902A (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57146595A (en) * | 1981-02-02 | 1982-09-10 | Searle & Co | Production of amino protected-l- aspartyl-l-phenylalanine alkyl ester |
US4506011A (en) * | 1981-09-05 | 1985-03-19 | Toyo Soda Manufacturing Co., Ltd. | Process for preparation of aspartylphenylalanine alkyl esters |
DE3361649D1 (en) * | 1982-01-26 | 1986-02-13 | Imahori Kazutomo | Process for synthesizing peptides or peptide derivatives |
EP0092228B1 (en) * | 1982-04-19 | 1988-01-20 | Nissan Motor Co., Ltd. | Method and apparatus for controlling reduction ratio of continuously variable transmission |
JPH0724587B2 (en) * | 1982-07-08 | 1995-03-22 | 三井東圧化学株式会社 | Reaction method using enzyme |
JPS5917997A (en) * | 1982-07-23 | 1984-01-30 | Toyo Soda Mfg Co Ltd | Preparation of addition compound from dipeptide ester and amino acid ester |
DE3479214D1 (en) * | 1983-04-28 | 1989-09-07 | Ajinomoto Kk | Process for the production of l-aspartyl-l-phenylalanine methyl ester or l-aspartyl-l-phenylalanine |
DE3690076T1 (en) * | 1985-02-15 | 1987-03-12 | ||
US4873359A (en) * | 1985-10-21 | 1989-10-10 | W. R. Grace & Co. - Conn. | Process for preparing as partyl-phenylalanine dipeptides |
NZ217813A (en) * | 1985-10-21 | 1991-01-29 | Grace W R & Co | Dipeptides and process for their preparation using an enzyme coupling agent |
US4810817A (en) * | 1985-10-21 | 1989-03-07 | W. R. Grace & Co. | Aspartyl-beta substituted phenylalanine dipeptides |
FR2589480B1 (en) * | 1985-11-05 | 1988-09-16 | Hoechst France | BIOLOGICAL PROCESS FOR THE PREPARATION OF METHYL N-(N-BENZYLOXYCARBONYL L-ASPARTYL-1) L-PHENYLALANINATE |
US4935355A (en) * | 1986-04-15 | 1990-06-19 | Synthetech, Inc. | Preparation of dipeptides |
CA1339674C (en) * | 1986-11-21 | 1998-02-17 | Genencor, Inc. | Enzymatic l-aspartyl-l-phenylalanine alkyl ester production |
US4892820A (en) * | 1987-06-10 | 1990-01-09 | The Nutrasweet Company | Solvent system for enzymatic coupling process |
JPH0279993A (en) * | 1987-12-11 | 1990-03-20 | Fan Shun Mou Ii Yuu Shen Kun Tsu | Production of l, l-dipeptide aspartame |
EP0344803B1 (en) * | 1988-06-03 | 1995-09-13 | Sharp Kabushiki Kaisha | Electronic device with calendar function |
US5002872A (en) * | 1989-05-10 | 1991-03-26 | W. R. Grace & Co.-Conn. | Enzyme mediated coupling reactions |
KR930002966B1 (en) * | 1990-11-24 | 1993-04-16 | 주식회사 미 원 | Process for producing dipeptide |
DE4408534A1 (en) * | 1994-03-14 | 1995-09-28 | Hoechst Ag | Substituted N-ethyl-glycine derivatives for the production of PNA and PNA / DNA hybrids |
US6465650B1 (en) | 1995-03-13 | 2002-10-15 | Aventis Pharma Deutschland Gmbh | Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids |
CA2172022A1 (en) * | 1995-03-20 | 1996-09-21 | Tsugio Murakami | Method for crystallizing alpha-l-aspartyl-l-phenylalanine methyl ester |
ATE202146T1 (en) * | 1995-10-11 | 2001-06-15 | Holland Sweetener Co | IMPROVED ENZYMATIC COUPLING REACTION OF N-PROTECTED L-ASPARAGIC ACID AND PHENYLALANINE METHYL ESTER |
EP0768384B1 (en) * | 1995-10-11 | 2001-06-13 | Holland Sweetener Company V.o.F. | Improved enzymatic coupling reaction of N-protected-L-aspartic acid and phenylalanine methyl ester |
US5837483A (en) * | 1996-10-15 | 1998-11-17 | Holland Sweetener Company V.O.F. | Enzymatic method for producing N-formyl-α-L-aspartyl-L-phenylalanine methyl ester |
WO1999062354A1 (en) * | 1998-06-05 | 1999-12-09 | Wm. Wrigley Jr. Company | Method of controlling release of n-substituted derivatives of aspartame in chewing gum and gum produced thereby |
US6692778B2 (en) * | 1998-06-05 | 2004-02-17 | Wm. Wrigley Jr. Company | Method of controlling release of N-substituted derivatives of aspartame in chewing gum |
CN112301081B (en) * | 2020-10-26 | 2022-07-22 | 江南大学 | Method for synthesizing phenylalanine oligopeptide-lysine oligopeptide copolymer through enzyme catalysis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972773A (en) * | 1975-04-29 | 1976-08-03 | Sagami Chemical Research Center | Process for producing peptide |
US4119493A (en) * | 1975-10-23 | 1978-10-10 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing a peptide |
DE2857828C2 (en) * | 1977-01-27 | 1990-06-07 | Toyo Soda Mfg. Co., Ltd., Shinnanyo, Yamaguchi, Jp |
-
1979
- 1979-04-03 JP JP4017079A patent/JPS55135595A/en active Granted
-
1980
- 1980-03-27 CA CA348,800A patent/CA1133841A/en not_active Expired
- 1980-04-01 NL NL8001902A patent/NL8001902A/en not_active Application Discontinuation
- 1980-04-01 US US06/136,347 patent/US4284721A/en not_active Expired - Lifetime
- 1980-04-01 DE DE19803012693 patent/DE3012693A1/en active Granted
- 1980-04-02 IT IT21154/80A patent/IT1147338B/en active
- 1980-04-02 BE BE0/200093A patent/BE882603A/en not_active IP Right Cessation
- 1980-04-02 GB GB8011159A patent/GB2049703B/en not_active Expired
- 1980-04-03 FR FR8007552A patent/FR2453137B1/en not_active Expired
- 1980-04-03 CH CH263880A patent/CH645341A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1147338B (en) | 1986-11-19 |
US4284721A (en) | 1981-08-18 |
NL8001902A (en) | 1980-10-07 |
DE3012693A1 (en) | 1980-10-16 |
BE882603A (en) | 1980-10-02 |
CH645341A5 (en) | 1984-09-28 |
JPS615399B2 (en) | 1986-02-18 |
JPS55135595A (en) | 1980-10-22 |
FR2453137B1 (en) | 1985-06-07 |
DE3012693C2 (en) | 1990-04-26 |
GB2049703A (en) | 1980-12-31 |
FR2453137A1 (en) | 1980-10-31 |
IT8021154A0 (en) | 1980-04-02 |
CA1133841A (en) | 1982-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19950402 |