GB2048097A - Fluid Filtration and Collection Apparatus - Google Patents
Fluid Filtration and Collection Apparatus Download PDFInfo
- Publication number
- GB2048097A GB2048097A GB7915665A GB7915665A GB2048097A GB 2048097 A GB2048097 A GB 2048097A GB 7915665 A GB7915665 A GB 7915665A GB 7915665 A GB7915665 A GB 7915665A GB 2048097 A GB2048097 A GB 2048097A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hollow body
- sample containing
- septum
- composite piston
- hollow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D33/00—Filters with filtering elements which move during the filtering operation
- B01D33/01—Filters with filtering elements which move during the filtering operation with translationally moving filtering elements, e.g. pistons
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A fluid collection apparatus which is useful for separating blood serum or plasma from blood cellular and particulate matter, comprises an elongate, transparent, hollow body (12) closeable at both ends. Proximate one end of the hollow body is a self- sealing septum (14) which abuts a composite piston member (16) including a central passageway (20) for receiving a filter element (30), a portion (18) adapted to extend into and close one end of the hollow body, means (22) for piercing the septum to provide communication with the interior of the hollow body and a lateral flange portion (16) for sealingly engaging the inner wall surface (46) of a tube (36) containing the mixture of materials being separated. As the apparatus is pushed into the tube (36), the liquid portion (44) of the mixture passes through the filter element into the hollow body where it is collected. Upon withdrawal of the apparatus, the flange of piston (16) engages the inner wall of the tube (36) and remains therein to seal the tube.
Description
SPECIFICATION
Fluid Collection Apparatus
The present invention relates to an apparatus for the separation of mixtures and is particularly useful in separating a fluid from a solid contained therein. The apparatus is well suited for the separation of blood plasma or serum from the blood cellular and partculate matter phase. In many laboratory and clinical situations, it is desired to separate a solid or semi-solid fraction of a mixture from a liquid fraction of the mixture.
This may be accomplished in a number of fashions.
As is well known, the market place is replete with fluid separators, many of which are adapted to specialized purposes and useable only for those purposes.
United States Patent 3,586,064 shows an apparatus for the collection of blood wherein a hollow central body is closed at both ends by piercable elastomeric seals. The seals are pierced by respective needles, so that when the device is inserted into a collection tube, one of the needles allows the liquid to flow into the interior of the hollow tube, while the other needle provides a vent to atmosphere. When sufficient sample has been collected, the atmosphere vent needle is withdrawn and the septum seals itself. Thereafter, the apparatus is withdrawn from the collection tube and the second needle is withdrawn, providing a self-sealing container for the collected sample.
United States Patent 3,837,376 shows a similar apparatus wherein both ends of the collecting apparatus are exposed to the atmosphere while the liquid sample is being forced into the collection apparatus, but in this case, only one needle is used whereby the needle has two vents to be disposed within the interior of the collection apparatus. During the collection operation, liquid flows from the sample containing tube through the needle, into the hollow body through the lower one of the two vents. After the fluid has been collected in the lower portion of the collection apparatus, both ports are again free of fluid and atmospheric communication through the needle vents is established with the interior of the sample containing tube. This facilitates the removal of the collection apparatus from the sample containing tube without interference of so-called vacuum lock problems.
A similar device is shown in United States
Patent 3,983,037 wherein a flexible walled hollow tube, closed at both ends, in penetrated at one end by a needle-like structure. The end of the needle-like structure which terminates inside the collection apparatus is attached to a filter so that fluid passing through the needle-like structure from the sample containing tube is filtered before it passes into the interior of the collection apparatus. To employ this device, the collection apparatus is compressed to form a partial vacuum on the interior.The needle-like portion protruding from the closed end of the collection apparatus is inserted under the surface of the fluid to be collected, and the pressure on the collection apparatus is released, thereby causing the fluid in the sample containing tube to be drawn up into the needle, passed through the filter, and be collected on the interior of the collection apparatus.
United States Patent No, 3,693,804 shows a pressure differential sampling device wherein the collection apparatus consists of a hollow body portion having one end closed by a piston filter assembly wherein a filter is fitted within a piston structure, and the piston filter structure is fitted within the hollow body of the collection apparatus. To employ the device, the assembly is forced into a sample containing tube so that the liquid is forced through the filter device into the interior of the hollow body portion of the collection apparatus. When sufficient sample has been collected, the collection apparatus is tilted sharply within the sample containing tube to break the seal therebetween and allow withdrawal of the entire apparatus.
In a similar device, United States Patent No.
4,057,499, shows a blood collection apparatus comprising a hollow body tube having a piston member inserted into one end thereof. The piston member is generally bell-shaped with the narrowest portion of the bell structure being inserted into the hollow-body member. The piston contains a filter member through which passes fluid to be collected. In the upper end of the bellshaped piston member is a one-way valve which allows the fluid to flow through the filter material and into the interior of the hollow body member of the collection apparatus. The composite piston member has a laterally extending flange which sealingly engages the interior wall of the sample containing tube while the collection apparatus is being forced into the sample tube to collect the fluid contained therein.Upon withdrawal of the entire collection apparatus, the flange of the piston folds over itself so that an upper radially grooved portion of the flange moves from its up position into a downward position, thereby breaking the seal between the flange member and the interior walls of the sample containing tube.
Many related fluid collection devices are known. For example, see United States Patent Nos. 3,687,296, 3,850,174, 3,875,012, and 3,931,815.
A number of problems have been evident in these prior art devices. One of the major problems is that when the collection apparatus is withdrawn from the sample containing tube, the bottom of the collection apparatus is contaminated with the material contained in the tube. This material, especially in medical circumstances, may contain pathogens or toxins which should not be exposed to the laboratory environment. Additionally, another major problem exists in that the removal of the collection apparatus leaves an open sample containing tube which is similarly disadvantageous from a contamination or spillage standpoint in a
laboratory.
The instant invention comtemplates a fluid -collection apparatus for the separation of a
mixture including an elongate, thin walled,
transparent, hollow body member whic is
closeable at both ends. Disposed at one end of
the hollow body is a self-sealing septum.
Disposed adjacent the septum is a closure means
which includes a composite piston member
having a laterally extending flange portion of a
greater diameter than the diameter of the hollow
body so that the flange portion extends past the
outer edge of the hollow body. A central
passageway extends through the body of the
composite piston and allows communication with
piercing means on the innermost end of the
composite piston. Disposed within the central
passageway is a filter element to effectively
prohibit the passage of solid material which is
mixed with the fluid fraction in the mixture frompassing into the interior space in the hollow body.
The composite piston member is configured so that it will be maintained as part of the hollow body assembly while the collection apparatus is being inserted into a sample collection tube. As the collection apparatus is forced in the sample collection tube, fluid in the mixture is forced
through the filter element contained in the
passage means and is vented to the interior of the
hollow body. When sufficient sample has been collected, the path of travel of the collection apparatus is reversed. Upon such reversal, the composite piston assembly detaches itself from the collection apparatus by withdrawing the piercing means through the self-sealing septum
and remaining behind in the sample containing tube with the composite piston. This composite
piston assembly effectively seals the sample
containing tube so that no contaminating material
is exposed to the laboratory.The septum
contained within the hollow body seals itself upon
removal of the piercing means, typically a needle, from it, and thereby seals at one end the collected fluid within the hollow body. The other end of the
hollow body is then sealed by closure means,
such as a snap-on cap, to form a shippable,
contamination free fluid collection apparatus,
according to the present invention. It is an object
of the present invention to provide an apparatus
for the collection of fluids in a mixture which is of
simple and sturdy design, which can be inserted
into a sample containing tube, and which can be
withdrawn without contaminating the exterior
portion of the apparatus.
Another object of the present invention is to
provide a simple, reliable apparatus which is
useful not only for the collection of a sample in a
non-contaminated container, but also contains
means to seal the sample containing tube and
thereby maintain any contaminating or hazardous
materials therein.
A further object of the present invention is to
provide an apparatus which is very simple in
design and composed of minimal parts which can be readily and economically manufactured and assembled.
Brief Description of the Drawings
The above objects and advantages will become readily apparent to one skilled in the art from reading the following detailed description of the present invention, when considered in light of the accompanying drawings, in which:
Figure 1 is an exploded sectional perspective view of a fluid collection apparatus embodying the salient features of the present invention:
Figure 2 is an enlarged sectional view of the assembled fluid collection apparatus illustrated in
Figure 1;
Figures 3a and 3c illustrate a schematic representation of the steps necessary to operate the apparatus illustrated in Figures 1 and 2; and
Figure 4 is an e#levational, partially sectional view of a modified form of the apparatus illustrated in Figures 1 and 2.
Referring to Figures 1 and 2, the present invention is embodied in an apparatus for the collection of a fluid contained in a mixture, usually a liquid and a solid. The apparatus is well suited for the separation of blood plasma or serum from the cellular and particulate phase of centrifuged blood. There is shown a fluid collection appartatus 10 in the form of an elongate, thin walled, transparent, hollow body 12. A septum 14 is adapted to be inserted into one end of the hollow body 12. The septum 14 is typically cylindrical in shape and formed of a self sealing plastic of rubber material. The septum 14 may be provided with an internally formed cavity 15 closed at the inner end thereof by a web portion 17. A composite piston 16 is formed to fit into the hollow body 12 and abut the septum 14.The composite piston 16 includes a unitary body 18 having at its outermost face a central passageway 20 which extends through most of the length of the unitary body 18 and terminates at the point of beginning of piercing means 22. The piercing means 22 is usually a plastic or steel needle. In the embodiment shown in Figures 1 and 2, the piercing means 22 is in the form of a hollow plastic needle which is blunt-nosed at the distal end 24. Along the length of the piercing means 22 and immediately below the distal end 24 are two vents 26 and 28 which allow fluid flow into the hollow body 12 from the exterior of the apparatus. A filter element 30 is disposed within the central passageway 20. The filter element 30 is usually a porous, plastic plug which restricts the flow of solid through the central passageway 20 and piercing means 22 and into the interior of the hollow body 12, but will allow fluid flow through the same path. The outermost end of the composite piston 16 includes a peripherally extending flange 32 which serves to sealingly engage the inner walls of a sample containing tube into which the fluid collection apparatus 10 is inserted, as will be described in detail herein after. A snap-on closure 34 is formed to close the uppermost or first end of the hollow body 12 and
is removed to employ the apparatus 10.
As shown in Figure 2, the apparatus 10 is
closed at one end by placing the snap-on closure
34 on the uppermost end of the apparatus 10.
The filter element 30 is formed so that it will fit
snugly within the central passageway 20.
Alternatively, the filter element 30 may be
secured in the central passageway 20 with a suitable adhesive. I Usually, the piercing means 22 is integral with the unitary body 18 of the
composite piston 16. When the piercing means
22 is formed of a plastic material, the entire
composite piston 1 6, except for the filter element
30, can be formed in a single mold in a one step
molding operation. After the filter element 30 is
secured within the central passageway 20, the
entire composite piston assembly 1 6 is typically
inserted into the lowermost end of the hollow
body 12 and pushed inwardly until the uppermost
end of the composite piston 1 6 abuts the lowermost face of the septum 14.The piston 1 6
is formed so that the uppermost surface of the
flange 32 engages the lowermost portion of the
hollow body 12. The piercing means 22 penetrates and passes through the cavity 15 and
the web portion 17 of the septum 14 and
provides fluid communication between the
exterior and the interior of the hollow body 12.
In the embodiment of the invention shown in
Figures 1 and 2, the septum 14 can be pre
pierced to facilitate the insertion of the blunt
nosed plastic needle. Also, the flange 32 is
beveled in shape to facilitate insertion of the
apparatus 10 into a sample containing tube and
to maintain the composite piston 16 in an upright
position in the sample containing tube.
Figure 3a through c show the steps necessary
to utilize the invention described in Figures 1 and
2.
In Figure 3a, there is shown the assembled
fluid collection apparatus 10 having the hollow
body 12, the composite piston 16, with its unitary
body 18, piercing means 22, flange 32 and filter
element 30. The apparatus 10 is inserted into a
sample containing tube 36, having an open end
38, a closed end 40, and a mixture contained
therein comprising a solid fraction 42 and a fluid
fraction 44. Figure 3a shows the apparatus 10
poised just above the sample containing tube 36,
ready to be inserted therein. As the apparatus 10
is inserted into the sample containing tube 36,
the flange 32 of the composite piston 1 6 engages
the inner wall 46 of the open end 38 of the
sample containing tube 36.As the apparatus 10
is forced downwardly into the bore of the sample
containing tube 36, the fluid 44 therein is forced
through the filter element 30 and through the
piercing means 22 and is collected as it flows
from the vents 26 and 28 on the piercing means
22 into the hollow body 12.
After the fluid 44 is collected, the path of travel
of the apparatus 10 is reversed. The piercing
means 22 is withdrawn from the septum 14 due
to the flange 32 being securely engaged to the
inner wall 46 of the sample containing tube 36.
The withdrawal of the hollow body 12 causes the web portion 1 7 of the septum 14 to automatically seal and thereby form a self-sealed fluid container, the outer surface of which is essentially contamination free due to the fact that no part of the exterior surface of the hollow body 12 or septum 14 has come in contact with an fraction of the solid 42 which may be a contaminant.
After the hollow body 12 and septum 14 portion of the assembly 10 is withdrawn from the tube 36, the composite piston 16, due to the flange 32 engaging the inner wall 46 of the tube 36, remains behind to seal the solid 42 within the tube 36. This forms a contamination free disposal vessel for the disposal of the solid. Many times the solid is a biological fluid, such as blood solids for example, which may contain contaminating materials which one would not want to be exposed to in the laboratory.
Another embodiment of the invention is shown in Figure 4. The apparatus 48 embodied in Figure 4 has an elongate, thin walled, transparent, hollow body 50 which is closed at its uppermost end by a screw type closure 52, having the closure 52 fitted with internal threads to engage external threads 54 on the exterior surface of the uppermost end of the hollow body 50. A septum 56 is disposed proximate the lowermost end of the hollow body 50. The septum 56 is formed of a self-sealing material, to be described in detail hereinafter. A composite piston 58 is also fitted into the lowermost portion of the hollow body 50.
The coniposite piston 58 comprises a unitary body 60 having a central passageway 62 extending therethrough. At the uppermost end of the composite piston is piercing means 64 which is adapted to pierce the septum 56.
Communication between the exterior and the interior of the hollow body 50 is provided through the hollow bore 66 and the central passageway 62. The piercing means 64 is usually a metal needle in this embodiment, with a rigid hollow body 67 and an internal hollow bore 66. A filter element 68 is disposed within the central passageway 62 of the composite piston 58, and a flange 70 extends from the unitary body 60.
The invention embodied in Figure 4 differs from the invention embodied in Figures 1 and 2 in that the closure means 52 at the uppermost end
is a threaded closure means; the flange 70 is not
beveled; and the piercing means 64 is a stainless
steel needle with a single bore 66, not pair of side vents like 26 and 28.
In the preferred embodiment shown in Figure 1 and 2, the hollow body 12 is a clear, rigid material such as plastic or glass. A plastic is preferred and cellulose acetate butyrate tubes having an outside diameter of 11 millimeters, an inside diameter of
10 millimeters and a length of about 100 millimeters have proved satisfactory. The septum - 14 is made of a self-sealing elastomeric material such as silicone rubber. The filter element 30 is a porous, plastic material which is dimensionally stable and rigid so that it may be formed into a cartridge shape to be inserted into the central passageway 20.
Generally, a 50 micron average pore size is adequate for use with most samples of biological origin. The pore size of the filter element 30 may be adjusted to meet any sample characteristics so long as the material meets the dimensional stability and compatability requirements above.
The composite piston body 18 is made of a rigid, dimensionally stable plastic, such as polyethylene. The snap-on closure 34 is also of a plastic but usually a flexible plastic like vinyl plastisol. When a plastic needle is employed as the piercing means 22, usually it is formed as an integral part of the unitary body 1 8 and is thus of the same composition, in this case polyethylene.
In the case of the invention embodied in Figure 4, the screw type closure 52 is of a plastic composition, typically a rigid polyethylene. The piercing means 64 is a metal needle, usually stainless steel. All other components are the same as those specified for the preferred embodiment shown in Figures 1 and 2.
The septum 56 in the embodiment shown in
Figure 4 need not be pre-pierced or have a cavity and web construction, since the metal needle used easily pierces the septum 56. Also, it is to be recognized that, the plastic needle need not have two side vents 26 and 28, one will serve well in the apparatus. The two vent configuration does show the advantage of being more easily molded than does the single side vent configuration.
In any case, other suitable materials may be used so long as they conform to any standards needed in regard to rigidity, dimensional stability, or chemical inertness to the sample. For example, the snap-on closure is usually made of a flexible vinyl plastisol but could also be made of a flexible polyethylene should the needs of the user require.
Since the apparatus may be readily employed to separate a reaction precipitate from a reaction supernatant fluid, solvent resistant plastic, glass, or metal components may be used where needed.
The apparatus of the invention is well suited to the separation of the liquid or fluid fraction of blood from the solid or semi-solid fraction thereof.
In such use, the blood to be sampled must be initially subjected to centrifugation. If the apparatus is used with whole blood, some cellular debris or whole cells may pass through the filter element and be collected along with the fluid fraction of the sample. Typically, whole blood is placed in a sample containing tube and centrifuged to precipitate the blood solids from the supernatant fluid. The fluid is plasma, if an anticoagulant is added, and the cellular matter is simply precipitated. The fluid is serum when no anticoagulant is added and a unitary clot is formed as the semi-solid precipitate. In either case, the whole blood is typically centrifuged prior to the use of the apparatus.
An important feature of the invention is that essentially only the lowermost face of the composite piston 16 and the interior surfaces of the closure 34, the hollow body 12, and the septum 14 are exposed to any contamination from the sample. This results in a relatively clean, contamination free surface for the outer surfaces of the closure 34, the hollow body 12, and the septum 14, and the uppermost portion of the composite piston 16. Therefore, any contaminating matter in the sample is held on the interior of the closures 34, the hollow body 12, and the septum 14, or at the bottom of the sample containing tube which is closed by the composite piston 16 and thereby provides a clean, shippable container for the fluid fraction; and a clean, easily disposable container for the solid fraction of the sample.
While a preferred and alternative embodiment of the present invention has been illustrated and described, it is understood that various modifications may be resorted to without departing from the scope of the appended claims.
Thus it will be seen that the present invention provides an apparatus which is inserted into a sample containing tube to physically separate the liquid from the solid fraction of the mixture. The present invention provides such as apparatus which is capable of separating the liquid from the solid fraction of a mixture by the insertion of the apparatus into a sample containing tube. After the separation has been effected, a self-sealing portion of the apparatus is withdrawn from the sample containing tube as a contamination free, shippable container having the sample of the liquid collected contained therein. Remaining behind in the collection tube is the piston member which effectively seals the sample containing tube, providing a contamination free, sealed disposal means for the contaminating solid contained in the sample containing tube.
Claims (12)
1. A fluid collection apparatus for the separation of a mixture comprising:
an elongate, transparent, hollow body having a first and a second open end;
closure means for said first end;
a self-sealing septum sealingly disposed within said body adjacent said second end; and
a composite piston adapted to be inserted into said second end of said hollow body, said composite piston including a unitary body having a central passageway therethrough, hollow piercing means adapted to pierce said septum and provide communication between said central passageway and the interior of said hollow body, a filter element disposed within said central passageway, and a laterally extending flange extending beyond the outer wall of said unitary body whereby when said apparatus is inserted into a sample containing tube a filtrate is adapted to pass through said filter element through said hollow piercing means and into the interior of said hollow body, such that when said apparatus is withdrawn from the sample containing tube, said flange maintains said composite piston is the sample containing tube.
2. The apparatus of claim 1 wherein said hollow body is of a plastic composition.
3. The apparatus of claim 2 wherein said plastic is cellulose acetate butyrate.
4. The apparatus of claim 1,2 or 3 wherein said self-sealing septum is of a silicone rubber.
5. The apparatus of claim 1, 2 or 3 or 4 wherein said composite piston is of a plastic composition.
6. The apparatus of claim 5 wherein said piston is of polyethylene.
7. The apparatus of any preceding claim wherein said filter element is of a plastic composition.
8. The apparatus of any preceding claim wherein said piercing means is a hollow needle.
9. The apparatus of claim 8 wherein said needle is of a plastic composition.
10. The apparatus of claim 8 wherein said needle is of a metal composition.
11. The apparatus of any preceding claim wherein said hollow body is a right circular cylinder.
12. The apparatus of claim 11 wherein said composite piston is a right circular cylinder and flange has a greater diameter than said unitary body.
1 3. A fluid collection apparatus constructed substantially as herein described with reference to and as illustrated in the drawings.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7915665A GB2048097B (en) | 1979-05-04 | 1979-05-04 | Fluid filtration and collection apparatus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7915665A GB2048097B (en) | 1979-05-04 | 1979-05-04 | Fluid filtration and collection apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2048097A true GB2048097A (en) | 1980-12-10 |
GB2048097B GB2048097B (en) | 1982-12-22 |
Family
ID=10504971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7915665A Expired GB2048097B (en) | 1979-05-04 | 1979-05-04 | Fluid filtration and collection apparatus |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2048097B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012085006A1 (en) * | 2010-12-21 | 2012-06-28 | Ge Healthcare Uk Limited | Filtration device and method |
-
1979
- 1979-05-04 GB GB7915665A patent/GB2048097B/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012085006A1 (en) * | 2010-12-21 | 2012-06-28 | Ge Healthcare Uk Limited | Filtration device and method |
CN103370134A (en) * | 2010-12-21 | 2013-10-23 | 通用电气医疗集团英国有限公司 | Filtration device and method |
CN103370134B (en) * | 2010-12-21 | 2015-12-16 | 通用电气医疗集团英国有限公司 | Filter and method |
US9919248B2 (en) | 2010-12-21 | 2018-03-20 | Ge Healthcare Uk Limited | Filtration device and method |
Also Published As
Publication number | Publication date |
---|---|
GB2048097B (en) | 1982-12-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4210623A (en) | Fluid collection apparatus | |
US4209488A (en) | Fluid collection apparatus | |
EP0283663B1 (en) | Blood separation system | |
US4131549A (en) | Serum separation device | |
US7500569B2 (en) | Plasma on demand tube | |
US4843017A (en) | Device for the separation of the lighter fraction from the heavier fraction of a liquid sample | |
JP4846894B2 (en) | Gathering assembly | |
EP1516585B1 (en) | Non-evacuated blood collection tube | |
US9028688B2 (en) | Instrument for separating blood and apparatus for separating blood | |
US4515752A (en) | Stopper for containers for use in analyses | |
US5354483A (en) | Double-ended tube for separating phases of blood | |
US3682596A (en) | Body fluid collector and separator having improved flow rate | |
EP2046499B1 (en) | Membrane-based double-layer tube for sample collections | |
US4957637A (en) | Serum separator system for centrifuge with piercable membrane | |
US5249711A (en) | Disposable dispensing pipette | |
GB2232599A (en) | One-step blood to plasma device | |
GB2048097A (en) | Fluid Filtration and Collection Apparatus | |
US5869158A (en) | Safety sampler | |
JPS6156766B2 (en) | ||
JPH0732766B2 (en) | Blood collection needle |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |