GB2040175A - Bubble oxygenator - Google Patents
Bubble oxygenator Download PDFInfo
- Publication number
- GB2040175A GB2040175A GB8000793A GB8000793A GB2040175A GB 2040175 A GB2040175 A GB 2040175A GB 8000793 A GB8000793 A GB 8000793A GB 8000793 A GB8000793 A GB 8000793A GB 2040175 A GB2040175 A GB 2040175A
- Authority
- GB
- United Kingdom
- Prior art keywords
- blood
- oxygenator
- heat exchanger
- foam
- accordance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
- A61M1/322—Antifoam; Defoaming
- A61M1/325—Surfactant coating; Improving wettability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Abstract
The disposable oxygenator is for use in an extracorporeal blood circuit and provides for blood from the patient to be oxygenated as it passes through the centre of a tubular sparger (22) with porous walls which supplies oxygen bubbles of the optimum size. The foaming blood is delivered to the top of the main oxygenator body where it is distributed by gravity flow downward across heat exchanger tubing (40). The heat exchanger is wound as a flat coil with all connections outside of the oxygenator body. A silicone-coated sponge (54) is located below the heat exchanger so that downwardly flowing foaming blood is defoamed as it passes through the sponge. Carbon dioxide and other gases are vented, and liquid blood gravitates into a tapered arterial reservoir (82). <IMAGE>
Description
SPECIFICATION
Bubble oxygenator
This invention is directed to an oxygenator for oxygenating and temperature-controlling blood in extracorporeal circulation during surgery.
Extracorporeal circulation has been a routine procedure in the operating room for several years.
An important component in the extracorporeal blood circuit is the blood oxygenator. The function of the oxygenator is to transfer oxygen into the venous blood so that the oxygen reacts with the hemoglobin with the resultant absorption of the oxygen and release of carbon dioxide. A historical survey of blood oxygenators was published in the December, 1961 issue of Surgery. The article was entitled "Theme and Variations of Blood Oxygenators," by
R.A. DeWall, et. al.
The three principle types of blood oxygenators are known. In the membrane oxygenator, a semipermeable membrane separates the blood from the oxygen, and gas exchange takes place by diffusion through the membrane. One type of membrane oxygenator is described in U.S. patent 3,413,095.
In the film oxygenator, a thin film of blood is exposed to an oxygen atmosphere. One type of film oxygenator is described in the December 1956 issue of The Lancet, page 1246, in an article entitled "Design of An Artificial Lung Using Polyvinyl Formal
Sponge."
The bubble oxygenator introduces bubbles of oxygen directly into the blood. In the bubble oxygenator described in U.S. patent 3,578,411, the bubble chamber has a continuous convoluted path to promote the intermixing of the blood and the oxygen. U.S. patent No. 3,807,958 describes a bubble oxygenator which employs a plurality of vertical tubes through which the blood and oxygen mixture rises. U.S. patent No. 3,898,045 describes a bubble oxygenator having a lattice chamber tightly packed with spherical beads which are asserted to improve gas exchange.In a bubble oxygenator described in an article published in the August, 1957 issue of
Surgery, which was entitled "Preliminary Studies On the Sponge-Oxygenator," by Adriano Bencini, et. al.
a long multi-perforated needle is positioned in a cylindrical piece of polyurethane sponge. In U.S,
patent 4,067,696, the rising flow of the blood and oxygen admixture passes through a three
dimensional open cell material which is asserted to
aid in gas exchange on the hemoglobin.
The present invention provides a blood oxygenator comprising: a substantially rigid housing, blood foaming means carried by said housing, including a venous blood inlet passageway, an oxygen inlet
passageway and porous sparger means associated with said blood and oxygen inlet passageways to
provide a flow of oxygen bubbles into the venous
blood to create a venous blood foam, blood foam
passage means communicating between said blood foaming means and an upper portion of said hous
ing, a heat exchanger carried in said housing below
said upper portion to control the temperature of
blood foam, and passage means for delivering blood foam to said heat exchanger, defoaming means carried in said housing below said heat exchanger to receive by gravitational flow the blood foam from the heat exchanger and to separate liquid blood and gas and thereby defoam the blood and an arterial blood reservoir, including an outlet therefrom, defined in said body below said defoaming means to collect liquid blood gravitating from said defoaming means.
Reference is now made to the accompanying drawings, wherein
Figure 7 is a plan view of an oxygenator of this invention.
Figure 2 is a perspective thereof on reduced scale showing the manner in which the oxygenator is connected to a system and is mounted.
Figure 3 is an isometric view similar to Figure 2, but showing the oxygenator mounted on a stand.
Figure 4 is a section taken generally along the line 4-4 of Figure 1, with parts broken away and parts taken in section.
Figure 5 is a section taken generally along the line 5-5 of Figure 4, with parts broken away.
Figure 6 is a detailed isometric view of the support clamp.
The preferred embodiment of the oxygenator of this invention is generally indicated at 10 in Figures 1 through 4. Oxygenator 10 is manufactured as a permanently assembled, low-cost, disposable unit which is principally made of injection-moulded parts so as to produce a substantially rigid structure which can be presterilized. The use of injection-moulded parts makes for high quality, reliable parts which can be inexpensively reproduced and assembled, and yet provide for the cleanliness and reproducibility which is important in such a structure.
In studying oxygenator 10 in structural and functional detail, it will be considered in the direction of blood flow therethrough. Venous blood inlet connection 12 is directed downwardly. This permits the venous connection tubing 14 (see Figure 2) which is directly connected to a venous cannula in the patient to hang in a half loop which makes it impossible for gas bubbles from the oxygenator to escape back towards the patient. Side fitting 16 is also an inlet fitting and is for the connection of tubing 18 from a cardiotomy reservoir, if one is used. If no cardiotomy reservoir is used in the procedure, then tubing 18 is clamped. Sample port 19 is connected by line 21 to connector 12 to obtain venous blood sample. A Luer
opening is provided for the sample syringe.
Sparger assembly 20, seen in sectional detail in
Figure 4, has a cylindrical tubular body within which
is fitted sparger tube 22. An exterior, cylindrical, tubular space around the sparger tube is open for the receipt of oxygen from oxygen connector 24. The
interior of sparger tube 22 has approximately the
interior diameter of venous blood inlet 12. Sparger tube 22 is a porous sparger. The porosity of sparger tube 22 is critical because it determines the size of the bubbles emitted. A porosity in the range of 90 "TEGRAGLAS," as manufactured by 3M company,
of Minneapolis, Minnesota, is proper, although
another similar structure may be used. If the oxygen
bubbles are too small, they oxygenate the blood but do not remove carbon dioxide. If the bubbles are too large, the opposite occurs with removal of carbon dioxide, but with inadequate oxygenation.With the porosity indicated, less than 1:1 gas-to-blood flow ratio produces the correct bubble size. A lesser oxygen flow produces smaller bubbles and more oxygenation and vice versa.
The tubular shape of the spargertube ensures that the entire volume of oxygen is evenly mixed with blood in a non-traumatic fashion. Since the oxygen bubbles flow inward into the blood, the blood is virtually floated over the inner surface of the sparger tube.
The sparger tube 22 may be made of or coated with a hydrophobic material. This would prevent the outward flow of blood therethrough should the oxygen supply lose pressure. Furthermore, the outside of the sparger tube 22 may have the coating thereon which serves as an anti-bacterial filter, to filter from the oxygen flow particles graded larger than 0.2 micron. The coating is a layer of paste which dries to a porous surface.
Some of the oxygenation and consequent carbon dioxide removal takes place in the initial bubbling phase as the blood foams in sparger tube 22 and as the foaming mass rises. The blood with the entrained oxygen bubbles (with oxygen-CO2 exchange beginning) proceeds upwardly propelled by gas flow, buoyancy, and the venous inflow of blood.
Manifold 26 guides the upward flowing, foaming blood into the top of dome 28 of the main body 30 of oxygenator 10. The dome 28 is part of the cover of the lower part of the body. Within dome 28, flat distributor plate 32 receives the foaming blood. The foaming blood proceeds horizontally across distributor plate 32. As the blood foam flows across flat distributor plate 32, it is visible because the cover of the dome is transparent. Thus, it is easy to inspect the blood to see that it becomes bright red (as compared to the dark red venous blood at the inlet) as the blood acquires oxygen. Should the inflow of venous flow be uneven (for example, the result of a suction that is too high), waves of foam can be seen traversing flat distributor plate 32. This serves as a good indicaTor to the perfusionist who will then reduce the inflow rate.
The path through which the blood foam travels is torturous, thus insuring total mixing and gas exchange. This makes it possible to use small amounts of oxygen per volume of blood. The low oxygen-toblood ratios mean less agitation of the blood, and thus less trauma to the blood cells. The lower oxygen ratio also produces less foaming so that less defoaming is required, together with the reduced oxygen cost.
Flat distributor plate 32 is spaced about 1/4 inch from the outside shell of dome 28, and thus the foaming blood is distributed around the edges where it descends by gravity onto perforated distributor plate 34. The flow space 36 around the edge of flat distributor plate 32 allows the blood foam to flow downward without allowing any large gas bubble accumulation. Perforations 38 may be circular holes or slots. The slots may be radially or angularly directed, or arranged in any distribution to evenly disburse the foam as it passes downward through the perforations 38.
A thin disc-shaped dispersing layer 39 of foam may be placed below distribution plate 34 and above heat exchanger 40. The foam is open-celled to permit blood flowtherethrough. The layer 39 may be uncoated to act as a distributor to evenly distribute the blood foam over heat exchanger 40, but preferably the foam layer 39 is silicone-coated. The silicone coating starts the vapour-liquid separation from the blood foam. This improves liquid blood contact with the coils of heat exchanger 40 to improve heat exchange efficiency. This layer is not always necessary.
Heat exchanger 40 is a pair of pancake-wound flat coil heat exchanger coils. Cone 42 in the centre of the coils is inserted to prevent the blood escaping through the centre of coils without heat exchanging.
The coils of heat exchanger 40 are wound in opposite spirals in the two pancakes and are wound onto a mandrel which produces the interior opening into which cone 42 is inserted. The heat exchanger coils have a small space between the pancake windings, such as small space 44 and, with the pancakes wound in opposite spirals, inevitably there are small spaces between the coils of the two pancakes. These spaces permit the downward flow of the blood foam between the coils, and yet with the small space, heat exchange is efficient.
The positioning of the coiled heat exchanger tubing is horizontal; the pancake position provides for slow, parallel blood flow on the surface of the coils and through the openings between the coils.
This also results in less cell damage. The horizontal positioning of the heat exchanger is useful in producing a low overall structure and in maximizing the arterial reservoir volume. The coils may be silicone-coated to encourage wet blood flow directly on the heat exchange coils without the insulating effect of entrained gas bubbles which provide the foam.
Another design feature presented by the particular heat exchange structure is the fact that the point where the heat exchanger tubing enters and leaves the oxygenator shell is above the blood level line at its highest point. In this way, complex sealing structures are not required, and there is no blood loss at the tube juncture and the body. There are no tubing joints within the body 30 of the oxygenator, but both free ends of the heat exchanger tubing are brought out of the body. As is seen in Figure 1 through 4, the coil ends 46 and 48 are shaped to have downwardly directed connections. This permits the connection of water tubing, such as tubing 50 and 52 (see Figure 2) by which the water circulation is established through the heat exchanger tubing.
Without a joint in the tubing within the shell, there is no danger of water leakage into the blood. The downwardly directed water connections enable the water-filled, heavily loaded lines to drape naturally.
Three-eighths or one-half inch outside diameter aluminium tubing is the preferred material to use as the heat exchanger. Such material is easily formed and sterilized, is inexpensive, and has good heat exchange properties. However, other suitable mate rials can alternatively be used.
Defoamer 54 is located interiorly of body 30 below heat exchanger 40. The foaming blood flow which is distributed all overthe heat exchanger coil descends from the heat exchanger coil onto defoamer 54. An open cell synthetic polymer composition material such as "Scottfoam," which is coated with silicone, is employed as the defoamer. The surface effect of the silicone separates the entrained gas from the liquid blood so that the gas moves upward and can be vented. Vent 56 is an opening in the cover of dome 28 for the addition of fluids and medications.
Gap 60 is provided at the periphery of dome 28 where it extends down around the top of the main body of the oxygenator.
The vent fitting 58 is provided so that vacuum can be attached to conduct harmful gases away from the oxygenator. Some of the anaesthetic gases used in the operating room are placed in the blood and are vented along with the carbon dioxide into the operating room when no other provision is made.
This may harm operating room personnel. (There have been some reported cases of trauma in operating room personnel caused by exposure to such anaesthetic gases.) Vent connector 58 permits the employment of vacuum to withdraw the vented gases out of the operating room. Dome 28 engages over body 30 and seals thereagainst, except the gap 60 is a vent opening which allows the free escape of the waste gases to the atmosphere. This escape is provided for those cases where it is not necessary to vent the gases out of the operating room. When vacuum is used through vent connector 58, free air is sucked into vent opening 60 and thus prevents lowering the pressure within the oxygenator 60 to subatmosphere.
Dome 28 has skirt 62 depending downwardly therefrom. This skirt guides the downwardly flowing blood foam onto the top of defoamer 54, and at the same time, provides an outer passage through which the separated gases can escape. Another circumferential body of defoamer sponge 64 is provided in this annular opening to ensure that no blood foam reaches the chamber 84 or outside of the oxygenator through vent connection 58 or vent opening 60.
Tray 66 supports the lower part of defoamer body 54 and has exterior walls 68 which constrain the sponge around the outer periphery. Tray 66 has feet 99 to rest on reservoir 84 of oxygenator body 30.
Gases or blood may pass between upper and lower parts of oxygenator 10. Filter section 72 is part of the tray and is a conical or cylindrical structure 72 having a bottom 74. The filter section 72 has its interior open to the space above tray 66 and may contain defoamer body 76. Filter 80 is a woven filter which presents little resistance to the flow of blood which passes down from the defoamer body 54 interiorly of filter section 72. Alternatively, filter 72 may be a moulded homogeneous porous structure. The blood outflowing through filter 80 from filter section 72 is thus subjected to final filtration. Filter 80 is preferably a woven mesh made from blood-compatible synthetic polymer composition material with a preferred porosity between 100 and 250 microns. The filter material is blood-wettable so that, when it is wet with blood, it prevents gaseous bubbles from passing through.This is the final separation of gas from the blood with the gas constrained on the inside of filter section 72. Despite this constraint, the arterial reservoir 82 also has its top open to the vents by the opening between the fit of the tray 66 onto shoulder 70 by means of feet 99.
Arterial reservoir 82 has enlarged large volumes at the top by means of shoulders 108 and 84 and a small volume at the bottom by the tapered body 86 of the arterial reservoir. This shape provides more resolution at the bottom end with a larger storage capacity at the top. The top end widens suddenly by shoulder 84, but this is at a level which is normally above the usual, normal blood level. Thus, should sudden reservoir capacity be required, it is available in a manner which requires little vertical space.
Further space is in shoulder 84 until reservoir overflow through vent opening 60.
Outlet pocket 88 is formed on the bottom of tapered body 86 of the reservoir. Outlet fittings 90 and 92 are for connection to outlet tubes 94 and 96.
The arterial outlet fitting 92 and its arterial tube line 96 deliver blood to the arterial pump and thence to the patient. Arterial fitting 90 and its tube 94 serve as a coronary perfusion outlet. Anti-vortex plate 98 is positioned over arterial outlet 88 to prevent vortex formation. Blood flow is unobstructed around the edges of the plate. The vortex plate permits the blood level to be drawn considerably lower in arterial reservoir 82 without ingesting air into the arterial outlet line by means of vortexing. The arterial outlet fittings 90 and 92 are directed downward so that outflow is straight downward. This permits the arterial tubing to hang down in a natural arch under the arterial reservoir without kinking.
Sample port 110 has a Luer opening for arterial blood sample-taking. The sample is taken through a tube positioned inside filter 80 and near the bottom of reservoir 82. If air is blown in through arterial sample port 110, the bubbles stay inside filter 80 and do not pass into the main arterial blood reservoir.
In use in the operating room, the heart-lung pump console usually has a vertical support rod 100 secured thereto. Clamp 102 carries an open metal hoop 104 thereon. Hoop 104 fits under shoulder 70 of body 30. Hoop 104 pivots around pin 105 so that the oxygenator can swing to any convenient position. The open gap 106 permits the oxygenator to be removed while the tubing is still attached to it without the necessity of removal or cutting the tubing. This makes removal and clean up more convenient, yet allows the operator to rotate the oxygenator into the desired position. Thus, the oxygenator 10 is easy to use.
The shape of the oxygenator is such that it can be placed close to the floor when in use, and thus blood can be drained into it more efficiently. Little priming volume is required so that the biological priming fluid or blood used for priming prior to surgery is of smaller volume to result in less cost, weight, and less risk of material contamination. Dynamic hold up is reduced to produce fast response.
Dimple 97 supports the filter structure and can receive an arterial reservoir temperature sensor.
This invention having been described in its preferred embodiment, it is clear that it is susceptible to numerous modifications and embodiments within the ability of those skilled in the art and without the exercise of the inventive faculty. Accordingly, the scope of this invention is defined by the scope of the following claims.
Claims (11)
1. A blood oxygenator comprising: a substantially rigid housing; blood foaming means carried by said housing, including a venous blood inlet passageway, an oxygen inlet passageway and porous sparger means associated with said blood and oxygen inlet passageways to provide a flow of oxygen bubbles into the venous blood to create venous blood foam; blood foam passage means communicating between said blood foaming means and an upper portion of said housing; a heat exchanger carried in said housing below said upper portion to control the temperature of blood foam, and passage means for delivering blood foam to said heat exchanger; defoaming means carried in said housing below said heat exchanger to receive by gravitational flow the blood foam from the heat exchanger and to separate liquid blood and gas and thereby defoam the blood; and an arterial blood reservoir, including an outlet therefrom, defined in said body below said defoaming means to collect liquid blood gravitating from said defoaming means.
2. An oxygenator in accordance with Claim 1, wherein said sparger is made of hydrophobic material and generally tubular shaped, with said venous blood inlet passageway extending therethrough.
3. An oxygenator in accordance with Claim 1 or 2 further comprising an oxygen filter on the exterior of said sparger to filter oxygen passing therethrough.
4. An oxygenator in accordance with Claim 1, 2 or 3, wherein said heat exchanger is horizontally disposed and substantially spans the flow path of blood foam between said blood foam passage means and said defoaming means.
5. An oxygenator in accordance with Claim 4 wherein said heat exchanger comprises a flat wound tubular coil.
6. An oxygenator in accordance with any preceding Claim, further comprising distributor means above said heat exchanger for receiving venous blood foam from said venous blood foam passage means and distributing it to said heat exchanger, said distributor means comprising a substantially flat, imperforate distributor plate adjacent the blood foam passage means and a perforated distributor plate therebelow, said perforated plate having perforations above said heat exchanger to relatively evenly deliver blood foam to said heat exchanger.
7. An oxygenator in accordance with any preceding Claim, wherein said heat exchanger comprises a continuous tube, the ends of which extend through said housing above the blood foaming level in said housing.
8. An oxygenator in accordance with any preceding Claim, further comprising an interior funnelshaped support member carried in said housing below said heat exchanger, said member carrying said defoaming means at its upper end and tapering toward its lower end to direct blood into said reservoir.
9. An oxygenator in accordance with Claim 8, further comprising filter means carried at the lower end of said support member to filter blood received from said support member as it passes into said reservoir.
10. An oxygenator in accordance with Claim 9, wherein said filter means comprises a tubular frame depending from said support element and carrying a synthetic polymer filter fabric.
11. An oxygenator constructed substantially as herein described with reference to the accompanying drawings.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US399479A | 1979-01-16 | 1979-01-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2040175B GB2040175B (en) | |
GB2040175A true GB2040175A (en) | 1980-08-28 |
Family
ID=21708599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8000793A Withdrawn GB2040175A (en) | 1979-01-16 | 1980-01-10 | Bubble oxygenator |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5596160A (en) |
AR (1) | AR221522A1 (en) |
AU (1) | AU5451380A (en) |
BE (1) | BE881131A (en) |
BR (1) | BR8000217A (en) |
CA (1) | CA1128827A (en) |
CH (1) | CH634995A5 (en) |
DE (1) | DE3001018A1 (en) |
ES (1) | ES487768A1 (en) |
FI (1) | FI794070A (en) |
FR (1) | FR2446642A1 (en) |
GB (1) | GB2040175A (en) |
IE (1) | IE49063B1 (en) |
IL (1) | IL58990A (en) |
IT (1) | IT1129511B (en) |
NL (1) | NL8000200A (en) |
SE (1) | SE8000306L (en) |
ZA (1) | ZA80159B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4396584A (en) * | 1981-06-01 | 1983-08-02 | Mike Burgess | Blood oxygenator |
EP0145158A1 (en) * | 1983-10-14 | 1985-06-19 | Texas Medical Products, Inc. | Bubble oxygenator |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758431A (en) * | 1980-04-14 | 1988-07-19 | Thomas Jefferson University | Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
US4830849A (en) * | 1980-04-14 | 1989-05-16 | Thomas Jefferson University | Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
US4795423A (en) * | 1980-04-14 | 1989-01-03 | Thomas Jefferson University | Oxygenated perfluorinated perfusion of the ocular globe to treat ischemic retinopathy |
US4840617A (en) * | 1980-04-14 | 1989-06-20 | Thomas Jefferson University | Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue |
US4657532A (en) * | 1985-07-19 | 1987-04-14 | Thomas Jefferson University | Intra-peritoneal perfusion of oxygenated fluorocarbon |
US4686085A (en) * | 1980-04-14 | 1987-08-11 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
JPS6411560A (en) * | 1987-07-07 | 1989-01-17 | Terumo Corp | Blood storage tank |
DE19919234A1 (en) | 1999-04-28 | 2000-11-16 | Fontaine Eng & Maschinen Gmbh | Coating system |
DE102008045621A1 (en) | 2008-09-03 | 2010-03-04 | Novalung Gmbh | Gas transfer device and use of a structured membrane |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1312112A (en) * | 1961-11-30 | 1962-12-14 | Device for blood processing | |
US3768977A (en) * | 1972-03-31 | 1973-10-30 | R Brumfield | Integral blood oxygenator and heat exchanger |
US3807958A (en) * | 1972-06-05 | 1974-04-30 | Harvey Res Corp William | A bubble oxygenerator including a blood foam return exchanger device |
US4268476A (en) * | 1975-06-06 | 1981-05-19 | Bentley Laboratories, Inc. | Blood oxygenator |
US4065264A (en) * | 1976-05-10 | 1977-12-27 | Shiley Laboratories, Inc. | Blood oxygenator with integral heat exchanger for regulating the temperature of blood in an extracorporeal circuit |
GB1604956A (en) * | 1977-12-23 | 1981-12-16 | Shiley Inc | Heat exchangers for regulating the temperature of blood in an extracorporeal circuit |
US4158693A (en) * | 1977-12-29 | 1979-06-19 | Texas Medical Products, Inc. | Blood oxygenator |
DE2907961A1 (en) * | 1978-03-02 | 1979-09-06 | Dso Metalchim | Apparatus for the enrichment of oxygen in blood |
-
1979
- 1979-12-18 IL IL58990A patent/IL58990A/en unknown
- 1979-12-26 JP JP17402679A patent/JPS5596160A/en active Pending
- 1979-12-27 FI FI794070A patent/FI794070A/en not_active Application Discontinuation
-
1980
- 1980-01-07 CA CA343,137A patent/CA1128827A/en not_active Expired
- 1980-01-10 GB GB8000793A patent/GB2040175A/en not_active Withdrawn
- 1980-01-10 ZA ZA00800159A patent/ZA80159B/en unknown
- 1980-01-10 AU AU54513/80A patent/AU5451380A/en not_active Abandoned
- 1980-01-11 AR AR279609A patent/AR221522A1/en active
- 1980-01-12 NL NL8000200A patent/NL8000200A/en not_active Application Discontinuation
- 1980-01-12 DE DE19803001018 patent/DE3001018A1/en not_active Withdrawn
- 1980-01-14 BR BR8000217A patent/BR8000217A/en unknown
- 1980-01-14 BE BE0/198952A patent/BE881131A/en not_active IP Right Cessation
- 1980-01-14 IT IT19211/80A patent/IT1129511B/en active
- 1980-01-15 SE SE8000306A patent/SE8000306L/en not_active Application Discontinuation
- 1980-01-15 IE IE83/80A patent/IE49063B1/en unknown
- 1980-01-15 CH CH31980A patent/CH634995A5/en not_active IP Right Cessation
- 1980-01-15 FR FR8000790A patent/FR2446642A1/en active Pending
- 1980-01-16 ES ES487768A patent/ES487768A1/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4396584A (en) * | 1981-06-01 | 1983-08-02 | Mike Burgess | Blood oxygenator |
EP0145158A1 (en) * | 1983-10-14 | 1985-06-19 | Texas Medical Products, Inc. | Bubble oxygenator |
Also Published As
Publication number | Publication date |
---|---|
DE3001018A1 (en) | 1980-07-17 |
FR2446642A1 (en) | 1980-08-14 |
ZA80159B (en) | 1981-01-28 |
IT1129511B (en) | 1986-06-04 |
BR8000217A (en) | 1980-09-23 |
IE800083L (en) | 1980-07-16 |
IT8019211A0 (en) | 1980-01-14 |
CH634995A5 (en) | 1983-03-15 |
SE8000306L (en) | 1980-07-17 |
ES487768A1 (en) | 1980-09-16 |
FI794070A (en) | 1980-07-17 |
CA1128827A (en) | 1982-08-03 |
IE49063B1 (en) | 1985-07-24 |
IL58990A0 (en) | 1980-03-31 |
BE881131A (en) | 1980-05-02 |
AR221522A1 (en) | 1981-02-13 |
JPS5596160A (en) | 1980-07-22 |
AU5451380A (en) | 1980-07-24 |
IL58990A (en) | 1983-06-15 |
NL8000200A (en) | 1980-07-18 |
GB2040175B (en) |
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