GB202100754D0 - Methods for high throughput screening of chimeric antigen receptors - Google Patents

Methods for high throughput screening of chimeric antigen receptors

Info

Publication number
GB202100754D0
GB202100754D0 GBGB2100754.7A GB202100754A GB202100754D0 GB 202100754 D0 GB202100754 D0 GB 202100754D0 GB 202100754 A GB202100754 A GB 202100754A GB 202100754 D0 GB202100754 D0 GB 202100754D0
Authority
GB
United Kingdom
Prior art keywords
methods
high throughput
chimeric antigen
throughput screening
antigen receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2100754.7A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coding Bio Ltd
Original Assignee
Coding Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coding Bio Ltd filed Critical Coding Bio Ltd
Priority to GBGB2100754.7A priority Critical patent/GB202100754D0/en
Publication of GB202100754D0 publication Critical patent/GB202100754D0/en
Priority to EP22705085.3A priority patent/EP4281566A1/en
Priority to PCT/GB2022/050158 priority patent/WO2022157500A1/en
Priority to US18/261,425 priority patent/US20240067955A1/en
Priority to CA3208273A priority patent/CA3208273A1/en
Ceased legal-status Critical Current

Links

GBGB2100754.7A 2021-01-20 2021-01-20 Methods for high throughput screening of chimeric antigen receptors Ceased GB202100754D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GBGB2100754.7A GB202100754D0 (en) 2021-01-20 2021-01-20 Methods for high throughput screening of chimeric antigen receptors
EP22705085.3A EP4281566A1 (en) 2021-01-20 2022-01-20 Methods for high throughput screening of chimeric antigen receptors
PCT/GB2022/050158 WO2022157500A1 (en) 2021-01-20 2022-01-20 Methods for high throughput screening of chimeric antigen receptors
US18/261,425 US20240067955A1 (en) 2021-01-20 2022-01-20 Methods for high throughput screening of chimeric antigen receptors
CA3208273A CA3208273A1 (en) 2021-01-20 2022-01-20 Methods for high throughput screening of chimeric antigen receptors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2100754.7A GB202100754D0 (en) 2021-01-20 2021-01-20 Methods for high throughput screening of chimeric antigen receptors

Publications (1)

Publication Number Publication Date
GB202100754D0 true GB202100754D0 (en) 2021-03-03

Family

ID=74678890

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2100754.7A Ceased GB202100754D0 (en) 2021-01-20 2021-01-20 Methods for high throughput screening of chimeric antigen receptors

Country Status (1)

Country Link
GB (1) GB202100754D0 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059782A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
US20170283504A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Bcma binding molecules and methods of use thereof
US20190161553A1 (en) 2017-11-01 2019-05-30 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059782A1 (en) 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
US20170283504A1 (en) 2016-04-01 2017-10-05 Kite Pharma, Inc. Bcma binding molecules and methods of use thereof
US20190161553A1 (en) 2017-11-01 2019-05-30 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
"CAR-T design: Elements and their synergistic function", EBIOMEDICINE, vol. 58, August 2020 (2020-08-01), pages 102931
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2016, JOHN WILEY & SONS
DI ROBERTO, R. B. ET AL.: "A functional Screening strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation", MOLECULAR THERAPY, vol. 28, no. 12, pages 2564 - 2576
GHORASHIAN, S.KRAMER, A. M.ONUOHA, S.WRIGHT, G.BARTRAM, J.RICHARDSON, R. ET AL.: "Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR", NATURE MEDICINE, 2019, Retrieved from the Internet <URL:https://doi.org/10.1038/s41591-019-0549-5>
GREENSAMBROOK: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
HOLT ET AL., TRENDS BIOTECHNOL., vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 90
HUDECEK, M.LUPO-STANGHELLINI, M. T.KOSASIH, P. L.SOMMERMEYER, D.JENSEN, M. C.RADER, C.RIDDELL, S. R.: "Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells", CLINICAL CANCER RESEARCH, 2013, Retrieved from the Internet <URL:https://doi.org/10.1158/1078-0432.CCR-13-0330>
JAMES, S. E.GREENBERG, P. D.JENSEN, M. C.LIN, Y.WANG, J.TILL, B. G. ET AL.: "Press, O. W. (2008). Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane", THE JOURNAL OF IMMUNOLOGY, Retrieved from the Internet <URL:https://doi.org/10.4049/jimmunol.180.10.7028>
LIU, X.JIANG, S.FANG, C.YANG, S.OLALERE, D.PEQUIGNOT, E. C. ET AL.: "Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice", CANCER RESEARCH, 2015, Retrieved from the Internet <URL:https://doi.org/10.1158/0008-5472.CAN-15-0159>
REVETS ET AL., EXPERT OPIN BIOL THER., vol. 5, no. 1, January 2005 (2005-01-01), pages 111 - 24
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
ZHANG, Z.JIANG, D.YANG, H.HE, Z.LIU, X.QIN, W. ET AL.: "Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor", CELL DEATH AND DISEASE, 2019, Retrieved from the Internet <URL:https://doi.org/10.1038/s41419-019-1711-1>

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)