GB202100754D0 - Methods for high throughput screening of chimeric antigen receptors - Google Patents
Methods for high throughput screening of chimeric antigen receptorsInfo
- Publication number
- GB202100754D0 GB202100754D0 GBGB2100754.7A GB202100754A GB202100754D0 GB 202100754 D0 GB202100754 D0 GB 202100754D0 GB 202100754 A GB202100754 A GB 202100754A GB 202100754 D0 GB202100754 D0 GB 202100754D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- methods
- high throughput
- chimeric antigen
- throughput screening
- antigen receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2100754.7A GB202100754D0 (en) | 2021-01-20 | 2021-01-20 | Methods for high throughput screening of chimeric antigen receptors |
EP22705085.3A EP4281566A1 (en) | 2021-01-20 | 2022-01-20 | Methods for high throughput screening of chimeric antigen receptors |
PCT/GB2022/050158 WO2022157500A1 (en) | 2021-01-20 | 2022-01-20 | Methods for high throughput screening of chimeric antigen receptors |
US18/261,425 US20240067955A1 (en) | 2021-01-20 | 2022-01-20 | Methods for high throughput screening of chimeric antigen receptors |
CA3208273A CA3208273A1 (en) | 2021-01-20 | 2022-01-20 | Methods for high throughput screening of chimeric antigen receptors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2100754.7A GB202100754D0 (en) | 2021-01-20 | 2021-01-20 | Methods for high throughput screening of chimeric antigen receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
GB202100754D0 true GB202100754D0 (en) | 2021-03-03 |
Family
ID=74678890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB2100754.7A Ceased GB202100754D0 (en) | 2021-01-20 | 2021-01-20 | Methods for high throughput screening of chimeric antigen receptors |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB202100754D0 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007059782A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
US20170283504A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Bcma binding molecules and methods of use thereof |
US20190161553A1 (en) | 2017-11-01 | 2019-05-30 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides |
-
2021
- 2021-01-20 GB GBGB2100754.7A patent/GB202100754D0/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007059782A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
US20170283504A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Bcma binding molecules and methods of use thereof |
US20190161553A1 (en) | 2017-11-01 | 2019-05-30 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen and encoding polynucleotides |
Non-Patent Citations (12)
Title |
---|
"CAR-T design: Elements and their synergistic function", EBIOMEDICINE, vol. 58, August 2020 (2020-08-01), pages 102931 |
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 2016, JOHN WILEY & SONS |
DI ROBERTO, R. B. ET AL.: "A functional Screening strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation", MOLECULAR THERAPY, vol. 28, no. 12, pages 2564 - 2576 |
GHORASHIAN, S.KRAMER, A. M.ONUOHA, S.WRIGHT, G.BARTRAM, J.RICHARDSON, R. ET AL.: "Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR", NATURE MEDICINE, 2019, Retrieved from the Internet <URL:https://doi.org/10.1038/s41591-019-0549-5> |
GREENSAMBROOK: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS |
HOLT ET AL., TRENDS BIOTECHNOL., vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 90 |
HUDECEK, M.LUPO-STANGHELLINI, M. T.KOSASIH, P. L.SOMMERMEYER, D.JENSEN, M. C.RADER, C.RIDDELL, S. R.: "Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells", CLINICAL CANCER RESEARCH, 2013, Retrieved from the Internet <URL:https://doi.org/10.1158/1078-0432.CCR-13-0330> |
JAMES, S. E.GREENBERG, P. D.JENSEN, M. C.LIN, Y.WANG, J.TILL, B. G. ET AL.: "Press, O. W. (2008). Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane", THE JOURNAL OF IMMUNOLOGY, Retrieved from the Internet <URL:https://doi.org/10.4049/jimmunol.180.10.7028> |
LIU, X.JIANG, S.FANG, C.YANG, S.OLALERE, D.PEQUIGNOT, E. C. ET AL.: "Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice", CANCER RESEARCH, 2015, Retrieved from the Internet <URL:https://doi.org/10.1158/0008-5472.CAN-15-0159> |
REVETS ET AL., EXPERT OPIN BIOL THER., vol. 5, no. 1, January 2005 (2005-01-01), pages 111 - 24 |
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546 |
ZHANG, Z.JIANG, D.YANG, H.HE, Z.LIU, X.QIN, W. ET AL.: "Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor", CELL DEATH AND DISEASE, 2019, Retrieved from the Internet <URL:https://doi.org/10.1038/s41419-019-1711-1> |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AT | Applications terminated before publication under section 16(1) |