GB2019214A - Anti-diabetic use of anthranilic acid derivatives - Google Patents

Anti-diabetic use of anthranilic acid derivatives

Info

Publication number
GB2019214A
GB2019214A GB7913457A GB7913457A GB2019214A GB 2019214 A GB2019214 A GB 2019214A GB 7913457 A GB7913457 A GB 7913457A GB 7913457 A GB7913457 A GB 7913457A GB 2019214 A GB2019214 A GB 2019214A
Authority
GB
United Kingdom
Prior art keywords
acid derivatives
anthranilic acid
hydrogen
diabetic use
6alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7913457A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB2019214A publication Critical patent/GB2019214A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pharmaceutical compositions containing anthranilic acid derivatives of formula I, <IMAGE> in which R0 is fluorine, chlorine, bromine, nitro or trifluoromethyl, R is hydrogen, C1-6alkyl or C2-4 alkanoyl, and R1 is hydrogen or C1-6alkyl, provided that a) when each of R and R1 is hydrogen, R0 is other than 5-chloro; and b) when R is acetyl and R1 is hydrogen, R0 is other than 5- or 6-chloro, 5-bromo or 5-trifluoromethyl, are indicated for use in treating diabetes.
GB7913457A 1978-04-20 1979-04-18 Anti-diabetic use of anthranilic acid derivatives Withdrawn GB2019214A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89816078A 1978-04-20 1978-04-20

Publications (1)

Publication Number Publication Date
GB2019214A true GB2019214A (en) 1979-10-31

Family

ID=25409043

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7913457A Withdrawn GB2019214A (en) 1978-04-20 1979-04-18 Anti-diabetic use of anthranilic acid derivatives

Country Status (12)

Country Link
JP (1) JPS54141747A (en)
AU (1) AU4610479A (en)
BE (1) BE875669A (en)
DE (1) DE2914935A1 (en)
FR (1) FR2430230A1 (en)
GB (1) GB2019214A (en)
IL (1) IL57090A0 (en)
IT (1) IT7948749A0 (en)
NL (1) NL7902908A (en)
NZ (1) NZ190206A (en)
SE (1) SE7903231L (en)
ZA (1) ZA791894B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0055629A1 (en) * 1980-12-29 1982-07-07 Hooker Chemicals & Plastics Corp. Process for preparing fluoroanthranilic compounds
EP0210574A2 (en) * 1985-07-31 1987-02-04 Hoechst Aktiengesellschaft N-substituted 5-nitro anthranilic acids, process for their preparation, their use and pharmaceutical compositions based on these compounds
US5741926A (en) * 1997-02-12 1998-04-21 Shaman Pharmaceuticals, Inc. Aniline derivatives having antihyperglycemic activity

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN152997B (en) * 1979-08-17 1984-05-19 Council Scient Ind Res
US5476849A (en) * 1984-03-19 1995-12-19 The Rockefeller University Methods for glycosylation inhibition using amino-benzoic acids and derivatives
US5514676A (en) * 1984-03-19 1996-05-07 The Rockefeller University Amino-benzoic acids and derivatives, and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7409M (en) * 1968-06-28 1969-11-03
DE2311020A1 (en) * 1973-03-06 1974-09-12 Pfizer SUBSTITUTED BENZOIC ACIDS AND MEDICINAL PRODUCTS
US4060638A (en) * 1975-05-27 1977-11-29 Sandoz, Inc. Anthranilic acid amides

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0055629A1 (en) * 1980-12-29 1982-07-07 Hooker Chemicals & Plastics Corp. Process for preparing fluoroanthranilic compounds
EP0210574A2 (en) * 1985-07-31 1987-02-04 Hoechst Aktiengesellschaft N-substituted 5-nitro anthranilic acids, process for their preparation, their use and pharmaceutical compositions based on these compounds
EP0210574A3 (en) * 1985-07-31 1988-07-20 Hoechst Aktiengesellschaft N-substituted 5-nitro anthranilic acids, process for their preparation, their use and pharmaceutical compositions based on these compounds
US5741926A (en) * 1997-02-12 1998-04-21 Shaman Pharmaceuticals, Inc. Aniline derivatives having antihyperglycemic activity

Also Published As

Publication number Publication date
DE2914935A1 (en) 1979-10-31
NZ190206A (en) 1981-07-13
NL7902908A (en) 1979-10-23
ZA791894B (en) 1980-11-26
JPS54141747A (en) 1979-11-05
BE875669A (en) 1979-10-18
AU4610479A (en) 1979-10-25
FR2430230A1 (en) 1980-02-01
SE7903231L (en) 1979-10-21
IL57090A0 (en) 1979-07-25
IT7948749A0 (en) 1979-04-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)