GB2014581A - Polypeptides and Methods for the Preparation Thereof - Google Patents

Polypeptides and Methods for the Preparation Thereof

Info

Publication number
GB2014581A
GB2014581A GB7847642A GB7847642A GB2014581A GB 2014581 A GB2014581 A GB 2014581A GB 7847642 A GB7847642 A GB 7847642A GB 7847642 A GB7847642 A GB 7847642A GB 2014581 A GB2014581 A GB 2014581A
Authority
GB
United Kingdom
Prior art keywords
polypeptides
seryl
methods
alamyl
asparagyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7847642A
Other versions
GB2014581B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/960,550 external-priority patent/US4232008A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB2014581A publication Critical patent/GB2014581A/en
Application granted granted Critical
Publication of GB2014581B publication Critical patent/GB2014581B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/062—Serum thymic factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Biologically active polypeptides containing the following polypeptide segment: -ALA-LYS-SER-GLN- are disclosed. Biological activity is generally retained upon substitution of an amino acid radical selected from L- asparagyl, L-glutamyl, L-threonyl, glycyl, L-valyl, L-leucyl, L-alamyl, L- seryl, sarcosyl, 2-methylalonyl, D- asparagyl, D-glutamyl, D-threonyl, D- valyl, D-leucyl, D-alamyl and D-seryl for either or both of L-alanyl in the first position and L-seryl in the third position, which polypeptides are capable of induction of the differentiation of T-lymphocytes, as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congential absence of thymus. Also provided are methods of manufacture of the polypeptides, therapeutic compositions, and methods of use of the polypeptides.
GB7847642A 1977-12-08 1978-12-07 Tetrapeptides and methods for the preparation thereof Expired GB2014581B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85849677A 1977-12-08 1977-12-08
US94053178A 1978-09-08 1978-09-08
US05/960,550 US4232008A (en) 1978-11-17 1978-11-17 Tetrapeptides and methods

Publications (2)

Publication Number Publication Date
GB2014581A true GB2014581A (en) 1979-08-30
GB2014581B GB2014581B (en) 1982-05-19

Family

ID=27420392

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7847642A Expired GB2014581B (en) 1977-12-08 1978-12-07 Tetrapeptides and methods for the preparation thereof

Country Status (19)

Country Link
JP (1) JPS5498719A (en)
CA (1) CA1120031A (en)
CH (1) CH642058A5 (en)
DE (1) DE2853002A1 (en)
DK (1) DK149595C (en)
ES (1) ES475857A1 (en)
FI (1) FI67368C (en)
FR (1) FR2411174A1 (en)
GB (1) GB2014581B (en)
GR (1) GR65013B (en)
IE (1) IE47611B1 (en)
IL (1) IL56150A (en)
IT (1) IT1110889B (en)
NL (1) NL7812004A (en)
NO (1) NO149631C (en)
NZ (1) NZ189101A (en)
PT (1) PT68883A (en)
SE (1) SE444687B (en)
YU (1) YU41322B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016611A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2 (en) * 1979-04-26 1980-11-12 Ortho Pharmaceutical Corporation Peptides and process for their preparation
WO2004004753A1 (en) * 2002-07-09 2004-01-15 Terentiev Alexandr Alexandrovi Peptide having an immunoregulatory property and the composition of said peptide

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215111A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity
US4426324A (en) * 1979-09-28 1984-01-17 Hoffmann-La Roche Inc. Immunopotentiating peptides
JPS5711950A (en) 1980-06-25 1982-01-21 Kureha Chem Ind Co Ltd Peptide and its synthesis
FR2546164B1 (en) * 1983-05-16 1987-07-17 Centre Nat Rech Scient NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ELASTASE INHIBITORS
FR2741076B1 (en) * 1995-11-15 1998-01-30 Rech De Pathologie Appliquee S PEPTIDE CONJUGATES DERIVED FROM THERMAL HORMONES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2544348C3 (en) * 1975-10-03 1979-12-13 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen L-leucine-13-motiline, process for its preparation and agent containing the same
FR2423481A2 (en) * 1978-04-21 1979-11-16 Anvar Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity
GB1572889A (en) * 1977-05-25 1980-08-06 Inst Nat Sante Rech Med Polypeptides
FR2391994A1 (en) * 1977-05-25 1978-12-22 Anvar Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016611A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0016611A3 (en) * 1979-03-14 1981-01-07 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2 (en) * 1979-04-26 1980-11-12 Ortho Pharmaceutical Corporation Peptides and process for their preparation
EP0018793A3 (en) * 1979-04-26 1981-01-07 Ortho Pharmaceutical Corporation Peptides and process for their preparation
WO2004004753A1 (en) * 2002-07-09 2004-01-15 Terentiev Alexandr Alexandrovi Peptide having an immunoregulatory property and the composition of said peptide

Also Published As

Publication number Publication date
NO784128L (en) 1979-06-11
IL56150A (en) 1982-02-28
CA1120031A (en) 1982-03-16
CH642058A5 (en) 1984-03-30
SE7812614L (en) 1979-06-09
FR2411174A1 (en) 1979-07-06
PT68883A (en) 1979-01-01
JPS6327360B2 (en) 1988-06-02
SE444687B (en) 1986-04-28
NZ189101A (en) 1984-07-06
GB2014581B (en) 1982-05-19
GR65013B (en) 1980-06-12
IT7852239A0 (en) 1978-12-07
IE47611B1 (en) 1984-05-02
IT1110889B (en) 1986-01-06
YU288078A (en) 1983-02-28
FR2411174B1 (en) 1984-05-25
DE2853002A1 (en) 1979-06-13
JPS5498719A (en) 1979-08-03
DK554078A (en) 1979-06-09
DK149595B (en) 1986-08-04
ES475857A1 (en) 1980-01-16
FI67368C (en) 1985-03-11
IE782423L (en) 1979-06-08
DK149595C (en) 1987-03-23
FI783769A (en) 1979-06-09
IL56150A0 (en) 1979-03-12
NO149631B (en) 1984-02-13
NL7812004A (en) 1979-06-12
FI67368B (en) 1984-11-30
NO149631C (en) 1984-05-23
YU41322B (en) 1987-02-28

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee