GB201315196D0 - Apparatus and method for determining the mechanical properties of cells - Google Patents

Apparatus and method for determining the mechanical properties of cells

Info

Publication number
GB201315196D0
GB201315196D0 GB201315196A GB201315196A GB201315196D0 GB 201315196 D0 GB201315196 D0 GB 201315196D0 GB 201315196 A GB201315196 A GB 201315196A GB 201315196 A GB201315196 A GB 201315196A GB 201315196 D0 GB201315196 D0 GB 201315196D0
Authority
GB
United Kingdom
Prior art keywords
cells
determining
mechanical properties
properties
mechanical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201315196A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
Original Assignee
Technische Universitaet Dresden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dresden filed Critical Technische Universitaet Dresden
Priority to GB201315196A priority Critical patent/GB201315196D0/en
Publication of GB201315196D0 publication Critical patent/GB201315196D0/en
Priority to PCT/EP2014/063532 priority patent/WO2015024690A1/en
Priority to US14/913,699 priority patent/US10571387B2/en
Priority to EP14732901.5A priority patent/EP3036520B1/en
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1023Microstructural devices for non-optical measurement
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429Signal processing
    • G01N15/1433Signal processing using image recognition
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484Optical investigation techniques, e.g. flow cytometry microstructural devices
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/11Region-based segmentation
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/40Extraction of image or video features
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693Acquisition
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V40/00Recognition of biometric, human-related or animal-related patterns in image or video data
    • G06V40/10Human or animal bodies, e.g. vehicle occupants or pedestrians; Body parts, e.g. hands
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0636Integrated biosensor, microarrays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Human Computer Interaction (AREA)
  • Medical Informatics (AREA)
  • Quality & Reliability (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
GB201315196A 2013-08-23 2013-08-23 Apparatus and method for determining the mechanical properties of cells Ceased GB201315196D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB201315196A GB201315196D0 (en) 2013-08-23 2013-08-23 Apparatus and method for determining the mechanical properties of cells
PCT/EP2014/063532 WO2015024690A1 (en) 2013-08-23 2014-06-26 Apparatus and method for determining the mechanical properties of cells
US14/913,699 US10571387B2 (en) 2013-08-23 2014-06-26 Apparatus and method for determining the mechanical properties of cells
EP14732901.5A EP3036520B1 (en) 2013-08-23 2014-06-26 Apparatus and method for determining the mechanical properties of cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201315196A GB201315196D0 (en) 2013-08-23 2013-08-23 Apparatus and method for determining the mechanical properties of cells

Publications (1)

Publication Number Publication Date
GB201315196D0 true GB201315196D0 (en) 2013-10-09

Family

ID=49355915

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201315196A Ceased GB201315196D0 (en) 2013-08-23 2013-08-23 Apparatus and method for determining the mechanical properties of cells

Country Status (4)

Country Link
US (1) US10571387B2 (en)
EP (1) EP3036520B1 (en)
GB (1) GB201315196D0 (en)
WO (1) WO2015024690A1 (en)

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EP2906928A4 (en) 2012-10-15 2016-11-09 Nanocellect Biomedical Inc Systems, apparatus, and methods for sorting particles
US20150338248A1 (en) * 2013-01-11 2015-11-26 Council Of Scientific & Industrial Research An optical fiber-based force transducer for microscale samples
EP2990742A1 (en) * 2014-08-28 2016-03-02 ABB Technology AG Method and apparatus for solidifying a polar substance
US10409704B1 (en) * 2015-10-05 2019-09-10 Quest Software Inc. Systems and methods for resource utilization reporting and analysis
GB2567788B (en) 2016-11-06 2022-04-20 Halliburton Energy Services Inc Automated inversion workflow for defect detection tools
DE102017201252A1 (en) 2017-01-26 2018-07-26 Universität Ulm Method and device for the examination of cells
DE102017008946A1 (en) * 2017-09-23 2019-03-28 Universität Greifswald Method of deforming deformable bodies and devices therefor
DE102017219565A1 (en) 2017-11-03 2019-05-09 Ernst-Moritz-Arndt-Universität Greifswald Method for quality control of cellular blood products
GB2575494A (en) * 2018-07-12 2020-01-15 Zellmechanik Dresden Gmbh Method of obtaining an indicator of patient sepsis and apparatus for such a method
CN109136081A (en) * 2018-07-30 2019-01-04 上海大学 Cancer cell separator and control system based on cells deformation amount and surface acoustic wave
DE102018221232A1 (en) 2018-12-07 2020-07-02 Universität Greifswald Diagnostic support method and apparatus therefor
CN111474106A (en) * 2019-01-23 2020-07-31 香港科技大学 Method and system for determining mechanical properties of biological cells or biological cell-like particles
EP3796212A1 (en) 2019-09-23 2021-03-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Device for image-based cell classification, method therefor and use thereof
JP7316912B2 (en) * 2019-11-12 2023-07-28 株式会社日立製作所 Cell sheet evaluation method
CN111744565B (en) * 2020-05-26 2022-03-08 东南大学 Microfluidic device and system for multi-channel parallel detection of cell deformability
CN112764596B (en) * 2021-01-18 2023-04-21 四川中微芯成科技有限公司 Capacitive touch anti-interference detection device, system and method
CN113008766B (en) * 2021-03-03 2022-08-23 北京理工大学 Cancer cell dynamic behavior detection system based on microfluidic multi-extrusion
CN113008765B (en) * 2021-03-03 2022-08-23 北京理工大学 Cancer cell dynamic behavior detection system adopting deformable micro-channel
EP4083607A1 (en) 2021-04-26 2022-11-02 ETH Zurich Method and microfluidic device for studying cell deformations
CN113533171A (en) * 2021-07-01 2021-10-22 芯峰科技(广州)有限公司 Cell deformation detection method and system based on deep learning and microfluidic chip
EP4122598B1 (en) 2021-07-20 2024-04-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A system for dissociation of solid biopsy and a method for inspection
CN114199835B (en) * 2021-11-05 2023-10-24 华南师范大学 Detection method of circulating tumor cells and application thereof
EP4209775A1 (en) 2022-01-05 2023-07-12 Friedrich-Alexander-Universität Erlangen-Nürnberg Method for determining a number of viscoelastic properties of a number of particles in a suspension, device for such a method and computer program or computer program product
US20230241611A1 (en) * 2022-01-31 2023-08-03 Tdk Corporation Devices and Methods for Sensing and Sorting Particles
EP4242658A1 (en) 2022-03-10 2023-09-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A system and method for biomolecule detection
CN114778422B (en) * 2022-04-19 2023-09-08 北京理工大学 Automatic cell sorting system and method based on micro-droplet control technology
EP4296645A1 (en) * 2022-06-24 2023-12-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and apparatus for determining rheological properties of deformable bodies
FR3140171A1 (en) 2022-09-23 2024-03-29 Centre National De La Recherche Scientifique DEVICE AND METHOD FOR THE CHARACTERIZATION OF CELLS SUBJECTED TO PHYSICAL STRAIN

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DE1815352C3 (en) 1968-12-18 1975-03-20 Wolfgang Prof. Dr. Dittrich Automatic measuring and counting device for the particles of a dispersion
FR2484077B1 (en) 1980-06-06 1984-07-06 Inst Nat Sante Rech Med METHOD AND DEVICE FOR MEASURING THE DEFORMABILITY OF LIVING CELLS, ESPECIALLY RED BLOOD CELLS
US5798827A (en) * 1996-11-26 1998-08-25 Coulter International Corp. Apparatus and method for determination of individual red blood cell shape
EP1059871B1 (en) 1998-03-04 2005-07-13 Guck Jochen Optical stretcher
JP3871456B2 (en) 1998-12-10 2007-01-24 シスメックス株式会社 Particle image analyzer
US7542131B2 (en) 2003-06-23 2009-06-02 Sewon Meditech, Inc. Apparatus for measuring blood cell deformability
US20070008528A1 (en) 2005-07-07 2007-01-11 Chi-Hung Lin Device and method for simultaneous optical trapping, stretching, and real-time detection and measurement for morphological deformation of micro-particles
EP2619545B1 (en) * 2010-09-22 2019-01-30 The Regents of The University of California System for high throughput cell deformability measurements
US9090865B2 (en) 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting

Also Published As

Publication number Publication date
US10571387B2 (en) 2020-02-25
US20160202172A1 (en) 2016-07-14
WO2015024690A1 (en) 2015-02-26
EP3036520B1 (en) 2017-07-26
EP3036520A1 (en) 2016-06-29

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Legal Events

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