GB2005019A - Magnetically attractable material for use in immunoassay - Google Patents

Magnetically attractable material for use in immunoassay

Info

Publication number
GB2005019A
GB2005019A GB7838582A GB7838582A GB2005019A GB 2005019 A GB2005019 A GB 2005019A GB 7838582 A GB7838582 A GB 7838582A GB 7838582 A GB7838582 A GB 7838582A GB 2005019 A GB2005019 A GB 2005019A
Authority
GB
United Kingdom
Prior art keywords
mixture
immunoassay
particulate
magnetically attractable
attractable material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7838582A
Other versions
GB2005019B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Priority to GB7838582A priority Critical patent/GB2005019B/en
Publication of GB2005019A publication Critical patent/GB2005019A/en
Application granted granted Critical
Publication of GB2005019B publication Critical patent/GB2005019B/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28026—Particles within, immobilised, dispersed, entrapped in or on a matrix, e.g. a resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28009—Magnetic properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/40—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the monomer composition prior to polymerisation

Abstract

A method of immunoassay of a liquid sample in which a reaction mixture is formed and one or more components of the mixture are selectively removed by contacting the mixture with a particulate reagent comprising a polymeric matrix having a selective absorbent material and magnetic particles incorporated therein. By applying a magnetic field, the particulate reagent can be separated from the mixture. The method may be effected by discrete manual techniques or by automated continuous flow analysis. The particulate reagents and their method of production constitute a further aspect of the invention.
GB7838582A 1977-09-28 1978-09-28 Magnetically attractable material Expired GB2005019B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7838582A GB2005019B (en) 1977-09-28 1978-09-28 Magnetically attractable material

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4037777 1977-09-28
GB7838582A GB2005019B (en) 1977-09-28 1978-09-28 Magnetically attractable material

Publications (2)

Publication Number Publication Date
GB2005019A true GB2005019A (en) 1979-04-11
GB2005019B GB2005019B (en) 1982-08-18

Family

ID=26264380

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7838582A Expired GB2005019B (en) 1977-09-28 1978-09-28 Magnetically attractable material

Country Status (1)

Country Link
GB (1) GB2005019B (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2454098A1 (en) * 1979-04-13 1980-11-07 Corning Glass Works SOLID-PHASE IMMUNOLOGICAL DETERMINATION METHOD USING MAGNETIC SUPPORT AND REAGENT USED IN THIS METHOD
EP0030087A1 (en) * 1979-11-13 1981-06-10 Technicon Instruments Company Limited Immunoassay method and apparatus and kit for carrying out the method
EP0111999A2 (en) * 1982-10-13 1984-06-27 Unitika Ltd. Spherical ion exchange resin, method for producing the same and method for adsorption treatment using the same
WO1988002866A1 (en) * 1986-10-14 1988-04-21 Serono Diagnostics Partners Automated analytical apparatus for measuring antigens or antibodies in biological fluids
WO1989006156A1 (en) * 1988-01-07 1989-07-13 Laube Hans Juergen Molecular sieve arrangement
US5698450A (en) * 1986-10-14 1997-12-16 Ringrose; Anthony Method for measuring antigens or antibodies in biological fluids
US5705402A (en) * 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5746974A (en) * 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
US5770459A (en) * 1986-04-30 1998-06-23 Igen International, Inc. Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5798083A (en) * 1988-11-03 1998-08-25 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
EP1152888A1 (en) * 1999-01-20 2001-11-14 Reference Diagnostics, Inc. Magnetically responsive gel particle
US6325973B1 (en) 1991-02-06 2001-12-04 Igen International, Inc. Methods and apparatus for improved luminescence assays
US6881589B1 (en) 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
CN102304231A (en) * 2011-05-30 2012-01-04 北京理工大学 Method for preparing super-absorbent material embedding object
US8211279B2 (en) 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
US8268264B2 (en) 2009-02-09 2012-09-18 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2454098A1 (en) * 1979-04-13 1980-11-07 Corning Glass Works SOLID-PHASE IMMUNOLOGICAL DETERMINATION METHOD USING MAGNETIC SUPPORT AND REAGENT USED IN THIS METHOD
EP0030087A1 (en) * 1979-11-13 1981-06-10 Technicon Instruments Company Limited Immunoassay method and apparatus and kit for carrying out the method
EP0111999A2 (en) * 1982-10-13 1984-06-27 Unitika Ltd. Spherical ion exchange resin, method for producing the same and method for adsorption treatment using the same
EP0111999A3 (en) * 1982-10-13 1985-04-10 Unitika Ltd. Spherical ion exchange resin, method for producing the same and method for adsorption treatment using the same
US5770459A (en) * 1986-04-30 1998-06-23 Igen International, Inc. Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection
WO1988002866A1 (en) * 1986-10-14 1988-04-21 Serono Diagnostics Partners Automated analytical apparatus for measuring antigens or antibodies in biological fluids
US5698450A (en) * 1986-10-14 1997-12-16 Ringrose; Anthony Method for measuring antigens or antibodies in biological fluids
US6881589B1 (en) 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
WO1989006156A1 (en) * 1988-01-07 1989-07-13 Laube Hans Juergen Molecular sieve arrangement
AU612777B2 (en) * 1988-01-07 1991-07-18 Hjl Projects & Developments Ltd Molecular sieve arrangement
US5149435A (en) * 1988-01-07 1992-09-22 H J L Projects & Developments Ltd. Molecular sieve arrangement and filtering method for removal of a selected constituent
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5746974A (en) * 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
US5798083A (en) * 1988-11-03 1998-08-25 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
US6078782A (en) * 1988-11-03 2000-06-20 Igen International Inc. Methods for improved particle electrochemiluminescence assays
US5705402A (en) * 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US6325973B1 (en) 1991-02-06 2001-12-04 Igen International, Inc. Methods and apparatus for improved luminescence assays
EP1152888A4 (en) * 1999-01-20 2003-08-06 Reference Diagnostics Inc Magnetically responsive gel particle
EP1152888A1 (en) * 1999-01-20 2001-11-14 Reference Diagnostics, Inc. Magnetically responsive gel particle
US8211279B2 (en) 2005-06-03 2012-07-03 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
US8702958B2 (en) 2005-06-03 2014-04-22 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
US8840774B2 (en) 2005-06-03 2014-09-23 Board Of Regents Of The University Of Texas System Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
US8268264B2 (en) 2009-02-09 2012-09-18 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles
CN102304231A (en) * 2011-05-30 2012-01-04 北京理工大学 Method for preparing super-absorbent material embedding object

Also Published As

Publication number Publication date
GB2005019B (en) 1982-08-18

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950928