GB1557757A - Process for preparing 16 methyl steroids - Google Patents
Process for preparing 16 methyl steroidsInfo
- Publication number
- GB1557757A GB1557757A GB1077878A GB1077878A GB1557757A GB 1557757 A GB1557757 A GB 1557757A GB 1077878 A GB1077878 A GB 1077878A GB 1077878 A GB1077878 A GB 1077878A GB 1557757 A GB1557757 A GB 1557757A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alpha
- acetoxypregna
- dioxo
- fluoro
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
To prepare 3,20-dioxo-9 alpha -fluoro-11 beta -hydroxy-16 alpha -methyl-21-acetoxypregna-1,4-diene , a methylmagnesium halide is reacted with 3,20-dioxo-9 alpha -fluoro-11 beta -hydroxy-21-acetoxypregna-1,4,16-triene in the presence of a catalytic quantity of a cuprous halide, the magnesium compound protonated, the resultant crude product acetylated by the action of an acetylating agent, the reacetylated crude product purified using an organic solvent, the product treated in solution using a peroxidising agent and again purified using an organic solvent. The compound obtained is an intermediate in the synthesis of dexamethasone 21-acetate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7708170A FR2383968A1 (en) | 1977-03-18 | 1977-03-18 | PROCESS FOR THE PREPARATION OF A 16A-METHYL STEROIDE |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1557757A true GB1557757A (en) | 1979-12-12 |
Family
ID=9188293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1077878A Expired GB1557757A (en) | 1977-03-18 | 1978-03-17 | Process for preparing 16 methyl steroids |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS53116362A (en) |
BE (1) | BE865043A (en) |
CA (1) | CA1117936A (en) |
CH (1) | CH629223A5 (en) |
DE (1) | DE2811540A1 (en) |
FR (1) | FR2383968A1 (en) |
GB (1) | GB1557757A (en) |
HU (1) | HU174829B (en) |
IE (1) | IE46586B1 (en) |
NL (1) | NL7802927A (en) |
PT (1) | PT67790A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2735501A1 (en) * | 1995-06-15 | 1996-12-20 | Payen & Cie L | Stretch cladded thick yarn prodn. covered with false twisted elements |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2244530B1 (en) * | 1973-07-27 | 1977-07-01 | Roussel Uclaf |
-
1977
- 1977-03-18 FR FR7708170A patent/FR2383968A1/en active Granted
-
1978
- 1978-02-24 CA CA000297709A patent/CA1117936A/en not_active Expired
- 1978-03-16 DE DE19782811540 patent/DE2811540A1/en active Granted
- 1978-03-17 HU HU78RO971A patent/HU174829B/en not_active IP Right Cessation
- 1978-03-17 NL NL7802927A patent/NL7802927A/en not_active Application Discontinuation
- 1978-03-17 PT PT6779078A patent/PT67790A/en unknown
- 1978-03-17 JP JP3002378A patent/JPS53116362A/en active Granted
- 1978-03-17 BE BE186056A patent/BE865043A/en not_active IP Right Cessation
- 1978-03-17 GB GB1077878A patent/GB1557757A/en not_active Expired
- 1978-03-17 CH CH294878A patent/CH629223A5/en not_active IP Right Cessation
- 1978-03-20 IE IE55378A patent/IE46586B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CH629223A5 (en) | 1982-04-15 |
DE2811540A1 (en) | 1978-09-21 |
IE780553L (en) | 1978-09-18 |
FR2383968B1 (en) | 1980-11-28 |
NL7802927A (en) | 1978-09-20 |
JPS6123799B2 (en) | 1986-06-07 |
HU174829B (en) | 1980-03-28 |
BE865043A (en) | 1978-09-18 |
FR2383968A1 (en) | 1978-10-13 |
CA1117936A (en) | 1982-02-09 |
IE46586B1 (en) | 1983-07-27 |
PT67790A (en) | 1978-04-01 |
JPS53116362A (en) | 1978-10-11 |
DE2811540C2 (en) | 1987-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940317 |