GB1541351A - 2-phenyl - 5 - (5 - tetrazolyl) - pyrimidin-4(3h)-one derivatives - Google Patents

2-phenyl - 5 - (5 - tetrazolyl) - pyrimidin-4(3h)-one derivatives

Info

Publication number
GB1541351A
GB1541351A GB5437/77A GB543777A GB1541351A GB 1541351 A GB1541351 A GB 1541351A GB 5437/77 A GB5437/77 A GB 5437/77A GB 543777 A GB543777 A GB 543777A GB 1541351 A GB1541351 A GB 1541351A
Authority
GB
United Kingdom
Prior art keywords
compounds
tetrazolyl
pyrimidin
phenyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5437/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/748,851 external-priority patent/US4082751A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1541351A publication Critical patent/GB1541351A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds of the formula I, in which the substituents have the meaning mentioned in Patent Claim 1, are obtained by reacting equimolar amounts of an appropriately substituted benzamidine with ethylethoxymethylene cyanoacetate, sodium azide and ammonium chloride in an inert organic solvent. The compounds have anti-allergic activity and are therefore suitable as medicaments, in particular for the prophylactic treatment of allergic bronchial asthma by the oral route. <IMAGE>
GB5437/77A 1976-02-13 1977-02-09 2-phenyl - 5 - (5 - tetrazolyl) - pyrimidin-4(3h)-one derivatives Expired GB1541351A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65778776A 1976-02-13 1976-02-13
US05/748,851 US4082751A (en) 1976-02-13 1976-12-08 Therapeutic agents

Publications (1)

Publication Number Publication Date
GB1541351A true GB1541351A (en) 1979-02-28

Family

ID=27097492

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5437/77A Expired GB1541351A (en) 1976-02-13 1977-02-09 2-phenyl - 5 - (5 - tetrazolyl) - pyrimidin-4(3h)-one derivatives

Country Status (14)

Country Link
JP (1) JPS52118481A (en)
AU (1) AU508970B2 (en)
CA (1) CA1083152A (en)
CH (1) CH635339A5 (en)
DE (1) DE2705609A1 (en)
DK (1) DK149044C (en)
FI (1) FI62533C (en)
FR (1) FR2340943A1 (en)
GB (1) GB1541351A (en)
IE (1) IE44603B1 (en)
LU (1) LU76722A1 (en)
NL (1) NL173055C (en)
SE (1) SE433494B (en)
YU (1) YU41567B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2383262A1 (en) * 2008-12-10 2011-11-02 Topharman Shanghai Co., Ltd. Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419357A (en) * 1982-01-18 1983-12-06 The Dow Chemical Company 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883653A (en) * 1972-10-24 1975-05-13 Pfizer Method of preventing asthmatic symptoms

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2383262A1 (en) * 2008-12-10 2011-11-02 Topharman Shanghai Co., Ltd. Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
EP2383262A4 (en) * 2008-12-10 2012-10-31 Topharman Shanghai Co Ltd Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
US8871777B2 (en) 2008-12-10 2014-10-28 Topharman Shanghai Co., Ltd. Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof

Also Published As

Publication number Publication date
IE44603L (en) 1977-08-13
CA1083152A (en) 1980-08-05
JPS6139947B2 (en) 1986-09-06
LU76722A1 (en) 1977-08-18
AU2189577A (en) 1978-08-10
DK149044C (en) 1986-06-02
AU508970B2 (en) 1980-04-17
DK57377A (en) 1977-08-14
IE44603B1 (en) 1982-01-27
JPS52118481A (en) 1977-10-04
FI770427A (en) 1977-08-14
DE2705609A1 (en) 1977-08-25
DE2705609C2 (en) 1988-12-15
FR2340943A1 (en) 1977-09-09
DK149044B (en) 1985-12-30
FI62533B (en) 1982-09-30
NL173055C (en) 1983-12-01
SE7701552L (en) 1977-09-23
FI62533C (en) 1983-01-10
NL7701483A (en) 1977-08-16
NL173055B (en) 1983-07-01
SE433494B (en) 1984-05-28
FR2340943B1 (en) 1981-01-09
YU35477A (en) 1982-10-31
YU41567B (en) 1987-10-31
CH635339A5 (en) 1983-03-31

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee