GB1537903A - 7-(alpha-(2-oxo-imidazolidin-1-yl-carbonylamino)-phenylacetamido)-cephalosporins processes for their preparation and their use as medicaments - Google Patents
7-(alpha-(2-oxo-imidazolidin-1-yl-carbonylamino)-phenylacetamido)-cephalosporins processes for their preparation and their use as medicamentsInfo
- Publication number
- GB1537903A GB1537903A GB44421/76A GB4442176A GB1537903A GB 1537903 A GB1537903 A GB 1537903A GB 44421/76 A GB44421/76 A GB 44421/76A GB 4442176 A GB4442176 A GB 4442176A GB 1537903 A GB1537903 A GB 1537903A
- Authority
- GB
- United Kingdom
- Prior art keywords
- medicaments
- cephalosporins
- phenylacetamido
- imidazolidin
- carbonylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Fodder In General (AREA)
Abstract
Novel cephalosporins of the formula <IMAGE> in which R1 represents hydrogen, alkyl or acyl and R2 represents hydrogen, alkyl or aryl and which can be present with respect to the centre of chirality C* in the two possible configurations R and S and as mixtures of the diastereomers resulting therefrom, and their non-toxic, pharmaceutically tolerable salts are prepared. These compounds are obtained by reacting an appropriate cephalosporin, which has an acetoxymethyl group in the 3-position, with a 5-mercapto-1,2,4-thiadiazole substituted in the 3-position by R1 in the presence of a base. Resulting compounds can be converted into the free acid and pharmaceutically tolerable salts. The novel cephalosporins are used as medicaments, in particular as antibacterial agents in infectious diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752548247 DE2548247A1 (en) | 1975-10-28 | 1975-10-28 | CEPHALOSPORINE, THE METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1537903A true GB1537903A (en) | 1979-01-10 |
Family
ID=5960287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44421/76A Expired GB1537903A (en) | 1975-10-28 | 1976-10-26 | 7-(alpha-(2-oxo-imidazolidin-1-yl-carbonylamino)-phenylacetamido)-cephalosporins processes for their preparation and their use as medicaments |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5253893A (en) |
| AT (1) | AT351163B (en) |
| AU (1) | AU502402B2 (en) |
| BE (1) | BE847729A (en) |
| CA (1) | CA1104562A (en) |
| CH (1) | CH623056A5 (en) |
| DD (1) | DD127949A5 (en) |
| DE (1) | DE2548247A1 (en) |
| DK (1) | DK485676A (en) |
| ES (1) | ES452779A1 (en) |
| FI (1) | FI763047A (en) |
| FR (1) | FR2329284A1 (en) |
| GB (1) | GB1537903A (en) |
| GR (1) | GR61406B (en) |
| IE (1) | IE44029B1 (en) |
| IL (1) | IL50761A (en) |
| LU (1) | LU76071A1 (en) |
| NL (1) | NL7611855A (en) |
| SE (1) | SE7611925L (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069639C (en) * | 1998-06-19 | 2001-08-15 | 山东沂蒙新华制药厂 | Preparation process of 1-chloroformyl-3-mesyl imidazolyl alkyl ketone |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK401088A (en) * | 1987-07-21 | 1989-01-22 | Kyoto Pharma Ind | CEPHALOSPOR CONNECTION, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION CONTAINING IT |
-
1975
- 1975-10-28 DE DE19752548247 patent/DE2548247A1/en not_active Withdrawn
-
1976
- 1976-10-25 IL IL50761A patent/IL50761A/en unknown
- 1976-10-25 CH CH1345476A patent/CH623056A5/en not_active IP Right Cessation
- 1976-10-26 GR GR52017A patent/GR61406B/en unknown
- 1976-10-26 NL NL7611855A patent/NL7611855A/en not_active Application Discontinuation
- 1976-10-26 FI FI763047A patent/FI763047A/fi not_active Application Discontinuation
- 1976-10-26 GB GB44421/76A patent/GB1537903A/en not_active Expired
- 1976-10-26 DD DD7600195465A patent/DD127949A5/en unknown
- 1976-10-26 JP JP51127903A patent/JPS5253893A/en active Pending
- 1976-10-26 LU LU76071A patent/LU76071A1/xx unknown
- 1976-10-26 CA CA264,207A patent/CA1104562A/en not_active Expired
- 1976-10-27 DK DK485676A patent/DK485676A/en unknown
- 1976-10-27 IE IE2375/76A patent/IE44029B1/en unknown
- 1976-10-27 SE SE7611925A patent/SE7611925L/en unknown
- 1976-10-27 ES ES452779A patent/ES452779A1/en not_active Expired
- 1976-10-28 AT AT802276A patent/AT351163B/en not_active IP Right Cessation
- 1976-10-28 AU AU19101/76A patent/AU502402B2/en not_active Expired
- 1976-10-28 FR FR7632616A patent/FR2329284A1/en active Granted
- 1976-10-28 BE BE171863A patent/BE847729A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069639C (en) * | 1998-06-19 | 2001-08-15 | 山东沂蒙新华制药厂 | Preparation process of 1-chloroformyl-3-mesyl imidazolyl alkyl ketone |
Also Published As
| Publication number | Publication date |
|---|---|
| AT351163B (en) | 1979-07-10 |
| IE44029B1 (en) | 1981-07-29 |
| IL50761A (en) | 1979-11-30 |
| AU1910176A (en) | 1978-05-04 |
| BE847729A (en) | 1977-04-28 |
| ES452779A1 (en) | 1978-01-01 |
| IE44029L (en) | 1977-04-28 |
| ATA802276A (en) | 1978-12-15 |
| GR61406B (en) | 1978-11-11 |
| FI763047A (en) | 1977-04-29 |
| LU76071A1 (en) | 1977-05-31 |
| AU502402B2 (en) | 1979-07-26 |
| JPS5253893A (en) | 1977-04-30 |
| CA1104562A (en) | 1981-07-07 |
| CH623056A5 (en) | 1981-05-15 |
| DK485676A (en) | 1977-04-29 |
| SE7611925L (en) | 1977-04-29 |
| FR2329284B1 (en) | 1978-12-15 |
| DE2548247A1 (en) | 1977-05-05 |
| NL7611855A (en) | 1977-05-02 |
| IL50761A0 (en) | 1976-12-31 |
| DD127949A5 (en) | 1977-10-19 |
| FR2329284A1 (en) | 1977-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |