GB1537199A - Intermediates in the preparation of sterols - Google Patents

Intermediates in the preparation of sterols

Info

Publication number
GB1537199A
GB1537199A GB30845/77A GB3084577A GB1537199A GB 1537199 A GB1537199 A GB 1537199A GB 30845/77 A GB30845/77 A GB 30845/77A GB 3084577 A GB3084577 A GB 3084577A GB 1537199 A GB1537199 A GB 1537199A
Authority
GB
United Kingdom
Prior art keywords
alpha
sterols
intermediates
preparation
cyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30845/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/708,821 external-priority patent/US4058538A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1537199A publication Critical patent/GB1537199A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Derivatives of 3 alpha ,5 alpha -cyclo-6 beta -alkoxy- DELTA <22>-25-hydroxysterol of the formula <IMAGE> in which R represents an alkyl radical having 1 to 6 carbon atoms and R<1>, R<2> and R<3>, which can be identical or different, represent hydrogen or methyl, are prepared. These compounds are obtained by reacting a 3 alpha ,5 alpha -cyclo-6 beta -alkoxynorcholane aldehyde with a corresponding ylide. The said compounds can be used for preparing 25-hydroxy cholesterol derivatives and 25-hydroxy vitamin D metabolites.
GB30845/77A 1976-07-26 1977-07-22 Intermediates in the preparation of sterols Expired GB1537199A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/708,821 US4058538A (en) 1975-01-27 1976-07-26 3α,5α-Cyclo-6β-alkoxy-α22 -bis-nor cholestene derivatives

Publications (1)

Publication Number Publication Date
GB1537199A true GB1537199A (en) 1978-12-29

Family

ID=24847311

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30845/77A Expired GB1537199A (en) 1976-07-26 1977-07-22 Intermediates in the preparation of sterols

Country Status (7)

Country Link
JP (1) JPS5318555A (en)
CH (1) CH631186A5 (en)
DE (1) DE2733116A1 (en)
FR (1) FR2400526A2 (en)
GB (1) GB1537199A (en)
IL (1) IL52435A0 (en)
NL (1) NL7707612A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3061478D1 (en) * 1979-05-18 1983-02-03 Hoffmann La Roche Process for the preparation of cholestene derivatives and intermediates in this preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994934A (en) * 1975-01-27 1976-11-30 The Upjohn Company Process for preparing Δ22 -25-oxy substituted sterol derivatives

Also Published As

Publication number Publication date
FR2400526B2 (en) 1982-07-09
FR2400526A2 (en) 1979-03-16
IL52435A0 (en) 1977-10-31
CH631186A5 (en) 1982-07-30
DE2733116A1 (en) 1978-02-02
JPS5318555A (en) 1978-02-20
NL7707612A (en) 1978-01-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee