GB1531418A - Perfluoro polycyclic compounds for use as synthetic blood and perfusion media - Google Patents

Perfluoro polycyclic compounds for use as synthetic blood and perfusion media

Info

Publication number
GB1531418A
GB1531418A GB50472/75A GB5047275A GB1531418A GB 1531418 A GB1531418 A GB 1531418A GB 50472/75 A GB50472/75 A GB 50472/75A GB 5047275 A GB5047275 A GB 5047275A GB 1531418 A GB1531418 A GB 1531418A
Authority
GB
United Kingdom
Prior art keywords
emulsions
transplanted
organs
perfluorination
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB50472/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Sun Ventures Inc
Original Assignee
Cincinnati Childrens Hospital Medical Center
Sun Ventures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center, Sun Ventures Inc filed Critical Cincinnati Childrens Hospital Medical Center
Publication of GB1531418A publication Critical patent/GB1531418A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Abstract

An emulsion for flushing organs to be transplanted is described, which contains perfluorinated hydrocarbons, dispersed in water, and additionally a non-toxic emulsifier. It must contain a total of more than 40% by volume of water. The perfluorinated materials are the perfluorination products of either (1) polycyclic hydrocarbons having at least two bridge head carbon atoms linked to each other via a bridge containing at least one carbon atom and which are not adamantane, or (2) methyladamantane, ethyladamantane, ethylmethyladamantane, ethyldimethyladamantane or triethyladamantane. These perfluorination products have an excellent dissolving capacity for oxygen and carbon dioxide and they form highly stable emulsions with good resistance to the high shearing forces which are applied to the emulsions when they flow through apparatuses which load the emulsions with the necessary oxygen, which they transport to the organs to be transplanted. The emulsions permit organs which are to be transplanted to be stored for a long time, and when, on the other hand, part of the emulsions reaches the human body as the organs through which the emulsions flow are transplanted, they are not toxic there and are excreted again after some time by way of respiration and via the skin.
GB50472/75A 1974-12-09 1975-12-09 Perfluoro polycyclic compounds for use as synthetic blood and perfusion media Expired GB1531418A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53079174A 1974-12-09 1974-12-09
US57976675A 1975-05-22 1975-05-22

Publications (1)

Publication Number Publication Date
GB1531418A true GB1531418A (en) 1978-11-08

Family

ID=27063372

Family Applications (1)

Application Number Title Priority Date Filing Date
GB50472/75A Expired GB1531418A (en) 1974-12-09 1975-12-09 Perfluoro polycyclic compounds for use as synthetic blood and perfusion media

Country Status (12)

Country Link
JP (1) JPS5753762B2 (en)
CA (1) CA1058081A (en)
CH (1) CH629938A5 (en)
DE (1) DE2555408A1 (en)
DK (1) DK154605C (en)
FI (1) FI54560C (en)
FR (1) FR2313024A1 (en)
GB (1) GB1531418A (en)
IT (1) IT1050731B (en)
NL (1) NL184995C (en)
NO (1) NO754103L (en)
SE (2) SE7513814L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2373289A2 (en) * 2008-12-08 2011-10-12 University of Utah Research Foundation Stable perfluorocarbon emulsion for use as an artificial oxygen carrier

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515198A1 (en) * 1981-10-22 1983-04-29 Centre Nat Rech Scient AQUEOUS MICROEMULSIONS OF FLUOROCARBONS INDUFINIMENTALLY STABLE AT A DATA TEMPERATURE, PROCESS FOR OBTAINING AND APPLICATION AS OXYGEN TRANSPORTERS
US4569784A (en) * 1980-11-17 1986-02-11 Adamantech, Inc. Preparation of a gel having gas transporting capability
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE4100059C2 (en) * 1991-01-03 1994-08-25 Adatomed Pharma & Med Treatment liquid for reapplication (detached) of detached retina to the choroid of the eye

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (en) * 1970-09-05 1978-09-15 Green Cross Corp
GB1343870A (en) * 1971-05-19 1974-01-16 Green Cross Corp Emulsions and the preparation thereof
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
JPS5331209B2 (en) * 1973-10-05 1978-09-01

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2373289A2 (en) * 2008-12-08 2011-10-12 University of Utah Research Foundation Stable perfluorocarbon emulsion for use as an artificial oxygen carrier
EP2373289A4 (en) * 2008-12-08 2014-07-02 Univ Utah Res Found Stable perfluorocarbon emulsion for use as an artificial oxygen carrier

Also Published As

Publication number Publication date
FI54560B (en) 1978-09-29
NL7514202A (en) 1976-06-11
FI54560C (en) 1979-01-10
NL184995B (en) 1989-08-01
JPS5198318A (en) 1976-08-30
NL184995C (en) 1990-01-02
CA1058081A (en) 1979-07-10
FR2313024A1 (en) 1976-12-31
DE2555408C2 (en) 1988-06-23
DE2555408A1 (en) 1976-06-10
DK154605B (en) 1988-12-05
NO754103L (en) 1976-06-10
JPS5753762B2 (en) 1982-11-15
IT1050731B (en) 1981-03-20
CH629938A5 (en) 1982-05-28
DK154605C (en) 1989-06-05
FI753442A (en) 1976-06-10
FR2313024B1 (en) 1980-05-23
DK554675A (en) 1976-06-10
SE7513814L (en) 1976-06-10
SE8300422D0 (en) 1983-01-27
SE8300422L (en) 1983-01-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19951208