GB1530975A - Halogenated derivatives of the 16alpha-methylpregnane series processes for preparing them and pharmaceutical compositions containing them - Google Patents
Halogenated derivatives of the 16alpha-methylpregnane series processes for preparing them and pharmaceutical compositions containing themInfo
- Publication number
- GB1530975A GB1530975A GB8713/77A GB871377A GB1530975A GB 1530975 A GB1530975 A GB 1530975A GB 8713/77 A GB8713/77 A GB 8713/77A GB 871377 A GB871377 A GB 871377A GB 1530975 A GB1530975 A GB 1530975A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylpregnane
- 16alpha
- preparing
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1530975 9,11 - Dihalo - 16 - methyl steroids ROUSSEL UCLAF 2 March 1977 [2 March 1976] 08713/77 Heading C2U The invention comprises compounds of formula (wherein L is H or C 1-18 acyl, and either X is Cl or Br and Y is Cl, or X is Cl and Y is F); and their preparation from the corresponding 9(11)- enes by halogenation, e.g. with an N-X-succinimide or -acetamide in conjunction with HY or LiY, optionally followed by acylation/deacylation interconversions at C-21. Topical anti-inflammatory compositions comprise a compound I and a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7605854A FR2342738A1 (en) | 1976-03-02 | 1976-03-02 | NEW HALOGEN DERIVATIVES OF THE 16A-METHYL PREGNANE SERIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1530975A true GB1530975A (en) | 1978-11-01 |
Family
ID=9169832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8713/77A Expired GB1530975A (en) | 1976-03-02 | 1977-03-02 | Halogenated derivatives of the 16alpha-methylpregnane series processes for preparing them and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS52106855A (en) |
| AT (1) | AT355237B (en) |
| AU (1) | AU509948B2 (en) |
| BE (1) | BE851944A (en) |
| CA (1) | CA1082170A (en) |
| CH (1) | CH619969A5 (en) |
| DE (1) | DE2709078C2 (en) |
| DK (1) | DK156401C (en) |
| FR (1) | FR2342738A1 (en) |
| GB (1) | GB1530975A (en) |
| IE (1) | IE44866B1 (en) |
| LU (1) | LU76867A1 (en) |
| NL (1) | NL7702166A (en) |
| PT (1) | PT66261B (en) |
| SE (1) | SE7702250L (en) |
| ZA (1) | ZA771078B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2127827A (en) * | 1982-10-05 | 1984-04-18 | Roussel Uclaf | Pregnane compounds |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2462443A1 (en) * | 1979-07-26 | 1981-02-13 | Roussel Uclaf | NEW HALOGENIC DERIVATIVE OF THE 16A-METHYL PREGNANE SERIES, PREPARATION METHOD AND APPLICATION AS MEDICINE |
| DE4433374A1 (en) * | 1994-09-20 | 1996-03-21 | Hoechst Ag | 17-deoxi-corticosteroid-21- / O / -carboxylic acid ester, process for their preparation and medicaments containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB928302A (en) * | 1958-06-20 | 1963-06-12 | Scherico Ltd | í¸-pregnene compounds |
| US3049554A (en) * | 1959-06-01 | 1962-08-14 | Schering Corp | 9, 11-dihalogeno-3, 20-diketopregnanes and processes for their manufacture |
-
1976
- 1976-03-02 FR FR7605854A patent/FR2342738A1/en active Granted
-
1977
- 1977-02-23 ZA ZA00771078A patent/ZA771078B/en unknown
- 1977-02-28 JP JP2039977A patent/JPS52106855A/en active Granted
- 1977-03-01 AT AT136577A patent/AT355237B/en not_active IP Right Cessation
- 1977-03-01 CA CA272,894A patent/CA1082170A/en not_active Expired
- 1977-03-01 SE SE7702250A patent/SE7702250L/en not_active Application Discontinuation
- 1977-03-01 LU LU76867A patent/LU76867A1/xx unknown
- 1977-03-01 AU AU22808/77A patent/AU509948B2/en not_active Expired
- 1977-03-01 DK DK088277A patent/DK156401C/en not_active IP Right Cessation
- 1977-03-01 NL NL7702166A patent/NL7702166A/en not_active Application Discontinuation
- 1977-03-01 BE BE175355A patent/BE851944A/en not_active IP Right Cessation
- 1977-03-02 PT PT66261A patent/PT66261B/en unknown
- 1977-03-02 CH CH264177A patent/CH619969A5/en not_active IP Right Cessation
- 1977-03-02 DE DE2709078A patent/DE2709078C2/en not_active Expired
- 1977-03-02 IE IE462/77A patent/IE44866B1/en unknown
- 1977-03-02 GB GB8713/77A patent/GB1530975A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2127827A (en) * | 1982-10-05 | 1984-04-18 | Roussel Uclaf | Pregnane compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2342738B1 (en) | 1979-10-12 |
| AU2280877A (en) | 1978-09-07 |
| PT66261A (en) | 1977-04-01 |
| DK156401C (en) | 1990-01-08 |
| BE851944A (en) | 1977-09-01 |
| SE7702250L (en) | 1977-09-03 |
| ATA136577A (en) | 1979-07-15 |
| DE2709078A1 (en) | 1977-09-08 |
| DE2709078C2 (en) | 1986-09-11 |
| JPS6150960B2 (en) | 1986-11-06 |
| IE44866L (en) | 1977-09-02 |
| FR2342738A1 (en) | 1977-09-30 |
| LU76867A1 (en) | 1977-09-26 |
| DK88277A (en) | 1977-09-03 |
| IE44866B1 (en) | 1982-04-21 |
| AT355237B (en) | 1980-02-25 |
| NL7702166A (en) | 1977-09-06 |
| PT66261B (en) | 1979-01-17 |
| ZA771078B (en) | 1978-04-26 |
| CH619969A5 (en) | 1980-10-31 |
| JPS52106855A (en) | 1977-09-07 |
| CA1082170A (en) | 1980-07-22 |
| AU509948B2 (en) | 1980-06-05 |
| DK156401B (en) | 1989-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940302 |