GB1523803A - 16-ethers of fusidic acid derivatives - Google Patents

16-ethers of fusidic acid derivatives

Info

Publication number
GB1523803A
GB1523803A GB26989/75A GB2698975A GB1523803A GB 1523803 A GB1523803 A GB 1523803A GB 26989/75 A GB26989/75 A GB 26989/75A GB 2698975 A GB2698975 A GB 2698975A GB 1523803 A GB1523803 A GB 1523803A
Authority
GB
United Kingdom
Prior art keywords
radical
hydroxy
substituted
alkyl
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26989/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to GB26989/75A priority Critical patent/GB1523803A/en
Priority to US05/693,976 priority patent/US4060606A/en
Priority to ZA763394A priority patent/ZA763394B/en
Priority to GR50927A priority patent/GR60362B/en
Priority to NZ181107A priority patent/NZ181107A/en
Priority to IE1227/76A priority patent/IE43478B1/en
Priority to AT438776A priority patent/AT345979B/en
Priority to FR7618949A priority patent/FR2315296A1/en
Priority to IT68542/76A priority patent/IT1062245B/en
Priority to PT65261A priority patent/PT65261A/en
Priority to DE2628360A priority patent/DE2628360C2/en
Priority to SE7607322A priority patent/SE7607322L/en
Priority to JP51073931A priority patent/JPS523051A/en
Priority to LU75239A priority patent/LU75239A1/xx
Priority to CA255,603A priority patent/CA1064906A/en
Priority to AU15250/76A priority patent/AU500027B2/en
Priority to FI761863A priority patent/FI55852C/en
Priority to ES449257A priority patent/ES449257A1/en
Priority to NL7606983A priority patent/NL7606983A/en
Priority to DK285776A priority patent/DK143905C/en
Priority to BE168348A priority patent/BE843446A/en
Priority to SU762374610A priority patent/SU799670A3/en
Publication of GB1523803A publication Critical patent/GB1523803A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1523803 Antibiotic compositions containing fusidic acid derivatives LEO PHARMACEUTICAL PRODUCTS Ltd AS 14 June 1976 [25 June 1975 7 Nov 1975] 26989/75 and 46229/75 Heading A5B [Also in Division C2] Antibacterial compositions for oral, parenteral, topical and rectal administration comprise a fusidic acid analogue of formula I or a pharmaceutically acceptable salt or "easily hydrolysable ester (defined) thereof in which the 24, 25-bond is single or double; Q, and Q 2 are each (H, α-OH) or oxo: A is O, S or S(O); R 1 is a C 1-8 alkyl radical optionally substituted with one or more halogen atoms or hydroxy, alkoxy, aralkoxy, aryloxy, alkanoyloxy, aralkanoyloxy, aroyloxy, mercapto, alkylthio, aralkylthio, arylthio, alkanoylthio, aroylthio, azido, nitro, cyano, thiocyanato, carboxy, alkoxycarbonyl, aryloxycarbonyl, amino, alkylamino, dialkylamino, arylamino, alkanoylamino, and aroylamino groups; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a cycloalkyl radical having from 3 to 7 carbon atoms in the ring, or a mono- or dihalo, C 1-4 alkyl, C 1-4 alkoxy or hydroxy substituted analogue thereof; an aryl, aralkyl or heterocyclylalkyl radical, which is unsubstituted Or substituted with one or more halogen atoms or nitro, C 1-4 alkyl, hydroxy or alkoxy groups; or an unsubstituted or methyl-substituted heterocyclic radical having 5 or 6 ring atoms and containing oxygen, sulphur or nitrogen atoms. The compositions may additionally contain hydrocortisone, triamcinolone, fluocinolone, amoxycillin, cephalexin, rifamycin, rifampicin, clindamycin, lincomycin, erythromycin, pivmecillinam, or tetracycline.
GB26989/75A 1975-06-25 1975-06-25 16-ethers of fusidic acid derivatives Expired GB1523803A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB26989/75A GB1523803A (en) 1975-06-25 1975-06-25 16-ethers of fusidic acid derivatives
US05/693,976 US4060606A (en) 1975-06-25 1976-06-08 16-Ethers of fusidic acid derivatives
ZA763394A ZA763394B (en) 1975-06-25 1976-06-08 New 16-ethers of fusidic acid derivatives
GR50927A GR60362B (en) 1975-06-25 1976-06-08 Preparation process of new 16-ethers of fusidic acid derivatives
NZ181107A NZ181107A (en) 1975-06-25 1976-06-09 16-hydroxycarbyloxy-16-deacet-oxyfusidic acid derivatives and analogs thereof
IE1227/76A IE43478B1 (en) 1975-06-25 1976-06-09 New 16-ethers of fusidic acid derivatives
AT438776A AT345979B (en) 1975-06-25 1976-06-16 PROCESS FOR MANUFACTURING NEW 16 ETHERS FROM FUSIDINE ACID DERIVATIVES
FR7618949A FR2315296A1 (en) 1975-06-25 1976-06-22 Antibacterial fusidinic acid derivs. - with a 16-beta-hydrocarbyl(oxy, thio or sulphinyl) substit. (NL281276)
IT68542/76A IT1062245B (en) 1975-06-25 1976-06-23 PROCEDURE FOR THE PREPARATION OF FUSIDIC ACID DERIVATIVES ETERIFIED IN POSITION 16
PT65261A PT65261A (en) 1975-06-25 1976-06-23 Process for the preparation of new 16-ethers of fusidic acid derivatives
DE2628360A DE2628360C2 (en) 1975-06-25 1976-06-24 Fusidic acid derivatives, process for their preparation and pharmaceutical agent containing them
SE7607322A SE7607322L (en) 1975-06-25 1976-06-24 PROCEDURE FOR THE PREPARATION OF 16-ETHARS OF FUSIDIC ACID DERIVATIVES
JP51073931A JPS523051A (en) 1975-06-25 1976-06-24 Production of fusidic acid derivatives and pharmaceutical agent containing the same
LU75239A LU75239A1 (en) 1975-06-25 1976-06-24
CA255,603A CA1064906A (en) 1975-06-25 1976-06-24 Process for the preparation of new 16-ethers of fusidic acid derivatives
AU15250/76A AU500027B2 (en) 1975-06-25 1976-06-24 16-ethers of fusidic acid derivatives
FI761863A FI55852C (en) 1975-06-25 1976-06-24 FORM OF FUSIDINE SYRADES
ES449257A ES449257A1 (en) 1975-06-25 1976-06-25 Production of fusidic acid derivatives and pharmaceutical agent containing the same
NL7606983A NL7606983A (en) 1975-06-25 1976-06-25 PROCESS FOR PREPARING THE 16 ETHERS OF FUSIDIC ACID DERIVATIVES.
DK285776A DK143905C (en) 1975-06-25 1976-06-25 ANALOGY PROCEDURE FOR THE PREPARATION OF FUSIC ACID DERIVATIVES
BE168348A BE843446A (en) 1975-06-25 1976-06-25 NEW 16-ETHERS OF FUSIDIC ACID DERIVATIVES, USEFUL AS ANTIMICROBIALS, AND THEIR PREPARATION PROCESS
SU762374610A SU799670A3 (en) 1975-06-25 1976-06-25 Method of preparing derivatives of fusidic acid or its salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26989/75A GB1523803A (en) 1975-06-25 1975-06-25 16-ethers of fusidic acid derivatives

Publications (1)

Publication Number Publication Date
GB1523803A true GB1523803A (en) 1978-09-06

Family

ID=10252386

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26989/75A Expired GB1523803A (en) 1975-06-25 1975-06-25 16-ethers of fusidic acid derivatives

Country Status (3)

Country Link
BE (1) BE843446A (en)
GB (1) GB1523803A (en)
ZA (1) ZA763394B (en)

Also Published As

Publication number Publication date
ZA763394B (en) 1977-05-25
BE843446A (en) 1976-12-27

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Legal Events

Date Code Title Description
PS Patent sealed
429A Application made for amendment of specification (sect. 29/1949)
429H Application (made) for amendment of specification now open to opposition (sect. 29/1949)
429D Case decided by the comptroller ** specification amended (sect. 29/1949)
SP Amendment (slips) printed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930614