GB1513432A - Pyridopyrazines - Google Patents

Pyridopyrazines

Info

Publication number
GB1513432A
GB1513432A GB2037775A GB2037775A GB1513432A GB 1513432 A GB1513432 A GB 1513432A GB 2037775 A GB2037775 A GB 2037775A GB 2037775 A GB2037775 A GB 2037775A GB 1513432 A GB1513432 A GB 1513432A
Authority
GB
United Kingdom
Prior art keywords
lower alkyl
substituted
phenyl
hydrogen
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2037775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1513432A publication Critical patent/GB1513432A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1513432 Pyridopyrazines E R SQUIBB & SONS Inc 14 May 1975 [25 July 1974] 20377/75 Heading C2C Novel compounds of Formula I wherein R, R 3 , R 4 and R 5 each is hydrogen or lower alkyl; R 1 and R 2 each is hydrogen, lower alkyl, lower alkanoyl, di(lower alkylamino)lower alkyl, phenyl, substituted phenyl, or is an unsubstituted or substituted heterocyclic of the group consisting of pyrrolidino, piperidino, or piperazino; wherein the substituted phenyl bears one or two lower alkyl, lower alkoxy, halogen, trifluoromethyl, amino or carboxy groups, and the substituted heterocyclics bear a hydroxy-lower alkyl, one or two lower alkyl or a phenyl group; and acid addition salts thereof and lower denotes groups containing up to 7 carbon atoms are prepared by reaction of a compound R 4 CO.COR 5 with a 3,4-diamino pyridine. Many intermediate substituted pyridines are prepared. Pharmaceutical compositions in conventional forms having anti-inflammatory, and tranquillising activity comprise an above novel compound and a carrier or diluent.
GB2037775A 1974-07-25 1975-05-14 Pyridopyrazines Expired GB1513432A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49188474A 1974-07-25 1974-07-25

Publications (1)

Publication Number Publication Date
GB1513432A true GB1513432A (en) 1978-06-07

Family

ID=23954069

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2037775A Expired GB1513432A (en) 1974-07-25 1975-05-14 Pyridopyrazines

Country Status (5)

Country Link
JP (1) JPS5136495A (en)
CA (1) CA1036605A (en)
DE (1) DE2530681A1 (en)
FR (1) FR2279405A1 (en)
GB (1) GB1513432A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201309508D0 (en) * 2013-05-28 2013-07-10 Redx Pharma Ltd Compounds

Also Published As

Publication number Publication date
CA1036605A (en) 1978-08-15
DE2530681A1 (en) 1976-02-05
JPS5136495A (en) 1976-03-27
FR2279405A1 (en) 1976-02-20

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee