GB1504589A - Substituted cephalosporin antibiotics - Google Patents
Substituted cephalosporin antibioticsInfo
- Publication number
- GB1504589A GB1504589A GB13383/75A GB1338375A GB1504589A GB 1504589 A GB1504589 A GB 1504589A GB 13383/75 A GB13383/75 A GB 13383/75A GB 1338375 A GB1338375 A GB 1338375A GB 1504589 A GB1504589 A GB 1504589A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- cephalosporin antibiotics
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 cephalosporin compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
- C07C273/1863—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process is described for the preparation of novel cephalosporin compounds of the formula I, which are substituted by a ureido radical, by reaction of a compound of the formula II with a compound of the formula (III) R''-NH-CO-N(R')-CO-A. These can be converted into the esters of the formula IV which are likewise new. The substituents in the compounds of the formula I and IV have the meanings stated in Claim 1 and Claim 10 respectively. The compounds of the formula I and IV have a high activity and a broad spectrum of action as antibiotics and are particularly suitable for the treatment of infections caused by Gram-negative microorganisms. <IMAGE>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45651674A | 1974-04-01 | 1974-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1504589A true GB1504589A (en) | 1978-03-22 |
Family
ID=23813076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13383/75A Expired GB1504589A (en) | 1974-04-01 | 1975-04-01 | Substituted cephalosporin antibiotics |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS614837B2 (en) |
| AR (1) | AR210258A1 (en) |
| AT (1) | AT337896B (en) |
| BE (1) | BE827408A (en) |
| BG (1) | BG27376A3 (en) |
| CA (1) | CA1096373A (en) |
| CH (1) | CH627471A5 (en) |
| CS (1) | CS196261B2 (en) |
| DD (1) | DD118648A5 (en) |
| DE (1) | DE2514019A1 (en) |
| DK (1) | DK130375A (en) |
| ES (1) | ES436198A1 (en) |
| FR (1) | FR2265394B1 (en) |
| GB (1) | GB1504589A (en) |
| HU (1) | HU170816B (en) |
| IE (1) | IE42705B1 (en) |
| IL (1) | IL46956A (en) |
| NL (1) | NL7503883A (en) |
| PH (1) | PH13642A (en) |
| PL (1) | PL101400B1 (en) |
| RO (1) | RO67392A (en) |
| SE (1) | SE423392B (en) |
| ZA (1) | ZA752004B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069639C (en) * | 1998-06-19 | 2001-08-15 | 山东沂蒙新华制药厂 | Preparation process of 1-chloroformyl-3-mesyl imidazolyl alkyl ketone |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4063019A (en) | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
-
1975
- 1975-03-26 DK DK130375A patent/DK130375A/da not_active Application Discontinuation
- 1975-03-28 IL IL46956A patent/IL46956A/en unknown
- 1975-03-28 HU HU75EI00000607A patent/HU170816B/en unknown
- 1975-03-29 DE DE19752514019 patent/DE2514019A1/en not_active Ceased
- 1975-03-29 BG BG7529484A patent/BG27376A3/en unknown
- 1975-03-29 PL PL1975179227A patent/PL101400B1/en unknown
- 1975-03-31 RO RO7581853A patent/RO67392A/en unknown
- 1975-03-31 PH PH16988A patent/PH13642A/en unknown
- 1975-04-01 NL NL7503883A patent/NL7503883A/en not_active Application Discontinuation
- 1975-04-01 JP JP50040203A patent/JPS614837B2/ja not_active Expired
- 1975-04-01 ZA ZA752004A patent/ZA752004B/en unknown
- 1975-04-01 CH CH411575A patent/CH627471A5/en not_active IP Right Cessation
- 1975-04-01 SE SE7503707-7A patent/SE423392B/en unknown
- 1975-04-01 CA CA223,530A patent/CA1096373A/en not_active Expired
- 1975-04-01 AT AT247675A patent/AT337896B/en not_active IP Right Cessation
- 1975-04-01 ES ES436198A patent/ES436198A1/en not_active Expired
- 1975-04-01 CS CS752206A patent/CS196261B2/en unknown
- 1975-04-01 DD DD185120A patent/DD118648A5/xx unknown
- 1975-04-01 FR FR7510143A patent/FR2265394B1/fr not_active Expired
- 1975-04-01 GB GB13383/75A patent/GB1504589A/en not_active Expired
- 1975-04-01 BE BE1006559A patent/BE827408A/en not_active IP Right Cessation
- 1975-04-02 IE IE705/75A patent/IE42705B1/en unknown
- 1975-04-10 AR AR258200A patent/AR210258A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069639C (en) * | 1998-06-19 | 2001-08-15 | 山东沂蒙新华制药厂 | Preparation process of 1-chloroformyl-3-mesyl imidazolyl alkyl ketone |
Also Published As
| Publication number | Publication date |
|---|---|
| AR210258A1 (en) | 1977-07-15 |
| JPS614837B2 (en) | 1986-02-13 |
| ATA247675A (en) | 1976-11-15 |
| CH627471A5 (en) | 1982-01-15 |
| FR2265394A1 (en) | 1975-10-24 |
| SE7503707L (en) | 1975-10-02 |
| DD118648A5 (en) | 1976-03-12 |
| BE827408A (en) | 1975-10-01 |
| PL101400B1 (en) | 1978-12-30 |
| RO67392A (en) | 1981-04-30 |
| BG27376A3 (en) | 1979-10-12 |
| PH13642A (en) | 1980-08-18 |
| AU7963775A (en) | 1976-09-30 |
| IL46956A (en) | 1979-10-31 |
| FR2265394B1 (en) | 1978-07-28 |
| HU170816B (en) | 1977-09-28 |
| SE423392B (en) | 1985-05-03 |
| IE42705L (en) | 1975-10-01 |
| DE2514019A1 (en) | 1975-10-02 |
| DK130375A (en) | 1975-10-02 |
| CS196261B2 (en) | 1980-03-31 |
| IE42705B1 (en) | 1980-10-08 |
| IL46956A0 (en) | 1975-05-22 |
| ZA752004B (en) | 1976-11-24 |
| CA1096373A (en) | 1981-02-24 |
| ES436198A1 (en) | 1977-01-01 |
| JPS50137995A (en) | 1975-11-01 |
| AT337896B (en) | 1977-07-25 |
| NL7503883A (en) | 1975-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8605405L (en) | PROCEDURE FOR PREPARING A SALT OF CLAVULANIC ACID | |
| SE7402101L (en) | ||
| GB1405886A (en) | Synergistic compositions comprising penicillin and cephalosporin antibiotics | |
| ES452361A1 (en) | Process for manufacture of 9-amino-9-deoxyclavulanates | |
| FR2255076A1 (en) | ||
| SE7501985L (en) | ||
| ES459261A1 (en) | Novel 3-acyloxymethyl-cephem compounds useful as intermediates for preparing cephalosporin antibiotics | |
| ES400452A1 (en) | Plant growth regulant compositions containing 2-haloethanesulphinic acid compounds | |
| GB1488420A (en) | Aminoglycosides | |
| GB1504589A (en) | Substituted cephalosporin antibiotics | |
| ES486023A1 (en) | Cephalosporin antibiotics | |
| GB1544819A (en) | Antibiotic substances derived from antibiotic 67-694(rosamicin)and processes for their preparation | |
| GB1066347A (en) | New derivatives of 7-amino-cephalosporamic acid and process for their manufacture | |
| GB1525626A (en) | Tetrazolethiomethyl cephalosporin compounds | |
| GB1547473A (en) | Cephalosporin compounds | |
| ES480762A1 (en) | Cephem derivatives, process for their preparation and pharmaceutical compositions containing them. | |
| SE7612961L (en) | TIENAMYCIN DERIVATIVES | |
| ES399014A1 (en) | (r)-1-(2-furoyloxy)-3-methylbutyl-pencillin compounds | |
| ES431688A1 (en) | 4-oxo-1-pyridinyl penicillin and cephalosporin derivatives | |
| GB876508A (en) | Improvements in or relating to substances having antibiotic activity | |
| JPS5646885A (en) | Novel cephamycin ester and its preparation | |
| GB1028563A (en) | Antibacterial derivative of 7-aminocephalosporanic acid | |
| ES449142A1 (en) | Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins | |
| GB1077465A (en) | Mercapto-phenoxymethyl-penicillins and a process for their manufacture | |
| GB1551672A (en) | Thienamycin derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |