GB1500582A - Cephalosporin derivatives - Google Patents
Cephalosporin derivativesInfo
- Publication number
- GB1500582A GB1500582A GB1439875A GB1439875A GB1500582A GB 1500582 A GB1500582 A GB 1500582A GB 1439875 A GB1439875 A GB 1439875A GB 1439875 A GB1439875 A GB 1439875A GB 1500582 A GB1500582 A GB 1500582A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- phenyl
- alkylamino
- thiadiazolyl
- tetrazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1500582 Cephalosporin-derived thiocarbamates and thiocarbonates E R SQUIBB & SONS Inc 8 April 1975 [10 May 1974 30 Aug 1974] 14398/75 Heading C2C [Also in Division C3] The invention comprises compounds of formula wherein R is H, C 1-7 alkyl, phenyl-C 1-7 alkyl a salt forming ion or the group and in addition, tri C 1-7 -alkyl)stannyl or phenyl when R<SP>1</SP> 2 is C 1-7 alkylthio; R 1 is H, C 1-7 alkyl, phenyl, thienyl, furyl or pyridyl; R<SP>1</SP> 2 is C 1-7 alkylthio, C 1-7 alkylamino or phenyl-C 1-7 -alkylamino; R 3 is C 1-7 alkyl, thiadiazolyl (C 1-7 alkyl), thiadiazolyl, triazolyl, tetrazolyl or (C 1-7 alkyl)- tetrazolyl when R<SP>1</SP> 2 is C 1-7 alkylthio, and when R<SP>1</SP> 2 is C 1-7 alkylamino or phenyl-C 1-7 -alkylamino, R 3 is thiadiazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, tetrazolyl, 1-oxidopyridyl or their C 1-7 alkyl derivatives; and R 4 is C 1-7 alkyl, phenyl or phenyl-C 1-7 -alkyl. In examples, these compounds are prepared by (1) N-acylating their 7-aminocephem analogues, or (2) converting R = CHPh 2 to H using CF 3 CO 2 H. Therapeutic compositions having antibacterial activity comprise compounds of the above formula and may be administered orally or parenterally.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US468727A US3929776A (en) | 1974-05-10 | 1974-05-10 | 3-Heterothio derivatives of {8 (thioalkoxycarbonyl)thioacetyl{9 cephalosporins |
US05/501,902 US3931170A (en) | 1974-08-30 | 1974-08-30 | 3-Heterothio derivatives of (carbamoylthioacetyl)cephalosporins |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1500582A true GB1500582A (en) | 1978-02-08 |
Family
ID=27042510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1439875A Expired GB1500582A (en) | 1974-05-10 | 1975-04-08 | Cephalosporin derivatives |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS50154285A (en) |
CA (1) | CA1056815A (en) |
DE (1) | DE2520829A1 (en) |
FR (1) | FR2269955B1 (en) |
GB (1) | GB1500582A (en) |
-
1975
- 1975-04-02 CA CA223,673A patent/CA1056815A/en not_active Expired
- 1975-04-08 GB GB1439875A patent/GB1500582A/en not_active Expired
- 1975-05-06 FR FR7514147A patent/FR2269955B1/fr not_active Expired
- 1975-05-09 DE DE19752520829 patent/DE2520829A1/en not_active Withdrawn
- 1975-05-10 JP JP5589875A patent/JPS50154285A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2269955B1 (en) | 1978-07-28 |
JPS50154285A (en) | 1975-12-12 |
FR2269955A1 (en) | 1975-12-05 |
DE2520829A1 (en) | 1975-11-20 |
CA1056815A (en) | 1979-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |