GB1496232A - Preparation of 2,4-difluorobiphenyl - Google Patents

Preparation of 2,4-difluorobiphenyl

Info

Publication number
GB1496232A
GB1496232A GB6938/77A GB693877A GB1496232A GB 1496232 A GB1496232 A GB 1496232A GB 6938/77 A GB6938/77 A GB 6938/77A GB 693877 A GB693877 A GB 693877A GB 1496232 A GB1496232 A GB 1496232A
Authority
GB
United Kingdom
Prior art keywords
difluorobiphenyl
july
prepared
acid
strong organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6938/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1496232A publication Critical patent/GB1496232A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Abstract

1496232 2,4-Difluorobiphenyl MERCK & CO Inc 16 July 1975 [22 July 1974 16 April 1975 1 May 1975] 06938/77 Divided out of 1496231 Heading C2C 2,4 - Difluorobiphenyl is prepared as in reaction of where X<SP>(-)</SP> is the anion of a mineral acid or a strong organic acid in the presence of a finely divided solid copper powder or copper salt and optionally in the presence of a strong organic acid for 1 to 20 hours at a temperature in the range 5‹ C. to reflux temperature. 2,4, - Difluorobenzenediazonium fluorborate was prepared by adding a nitrite to 2,4-difluoroanaline and fluoboric acid.
GB6938/77A 1974-07-22 1975-07-16 Preparation of 2,4-difluorobiphenyl Expired GB1496232A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (1)

Publication Number Publication Date
GB1496232A true GB1496232A (en) 1977-12-30

Family

ID=27413871

Family Applications (2)

Application Number Title Priority Date Filing Date
GB29879/75A Expired GB1496231A (en) 1974-07-22 1975-07-16 Chemical products
GB6938/77A Expired GB1496232A (en) 1974-07-22 1975-07-16 Preparation of 2,4-difluorobiphenyl

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB29879/75A Expired GB1496231A (en) 1974-07-22 1975-07-16 Chemical products

Country Status (11)

Country Link
JP (1) JPS5134135A (en)
CH (1) CH615146A5 (en)
DE (1) DE2532559C3 (en)
DK (1) DK145643C (en)
FR (1) FR2288729A1 (en)
GB (2) GB1496231A (en)
IE (1) IE41582B1 (en)
LU (1) LU73032A1 (en)
NL (1) NL188689C (en)
NO (1) NO143874C (en)
SE (1) SE428560B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (en) * 1980-10-21 1986-07-24 D & D Srl PYRIDOXY DERIVATIVES FOR THERAPEUTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (en) * 1992-04-06 1993-11-09 株式会社エースプレミアム Traveling toys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (en) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (en) * 1972-05-31 1974-02-13

Also Published As

Publication number Publication date
FR2288729A1 (en) 1976-05-21
LU73032A1 (en) 1976-07-01
JPS5134135A (en) 1976-03-23
FR2288729B1 (en) 1977-12-09
CH615146A5 (en) 1980-01-15
NO143874B (en) 1981-01-19
JPS569496B2 (en) 1981-03-02
NL7508127A (en) 1976-01-26
NO143874C (en) 1981-04-29
DK145643B (en) 1983-01-10
DK145643C (en) 1983-07-11
DK310075A (en) 1976-01-23
DE2532559C3 (en) 1979-10-04
SE7507764L (en) 1976-01-23
IE41582B1 (en) 1980-02-13
SE428560B (en) 1983-07-11
NO752482L (en) 1976-01-23
GB1496231A (en) 1977-12-30
DE2532559A1 (en) 1976-02-05
IE41582L (en) 1976-01-22
NL188689C (en) 1992-09-01
DE2532559B2 (en) 1979-02-15
NL188689B (en) 1992-04-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19950715