GB1494781A - Unsymmetrically substituted 1,4-dioxane-2,5-diones - Google Patents
Unsymmetrically substituted 1,4-dioxane-2,5-dionesInfo
- Publication number
- GB1494781A GB1494781A GB1003/75A GB100375A GB1494781A GB 1494781 A GB1494781 A GB 1494781A GB 1003/75 A GB1003/75 A GB 1003/75A GB 100375 A GB100375 A GB 100375A GB 1494781 A GB1494781 A GB 1494781A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diones
- dioxane
- alpha
- formula
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Dental Preparations (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The 1,4-dioxane-2,5-diones conform to the formula <IMAGE> in which R1, R2, R3 and R4 are as defined in Claim 1. They are prepared by a1) reacting an alpha -halo-, alpha -(lower alkanoyl)oxy- or alpha -(lower alkyl)sulphonyloxyacetic acid which is appropriately substituted by R1 and R2 with an alpha -hydroxyacetic acid which is appropriately substituted by R3 and R4 in the presence of a strongly acidic catalyst, or a2) reacting monochloroacetic acid with L-lactide or poly-(D,L-lactic acid) in the presence of antimony trioxide, titanium dioxide or tetraisopropyl titanate, b) rendering the resultant product alkaline, and c) cyclising the product. The homopolymers and copolymers of the 1,4-dioxane-2,5-diones of the formula I are compatible with living human and mammal tissue, can be used surgically and are biodegradable to give tissue-compatible components which are absorbed by living tissues. At least 2% by weight of the 1,4-dioxane-2,5-diones are copolymerised with compounds of the formula <IMAGE> in which R5, R6, R7 and R8 are as defined in Claim 6, by heating in the presence of a catalyst, giving polymers which contain at least 2% by weight of copolymerised compounds of the formula I. The polymers can be used for the production of shaped surgical aids which can be absorbed by living tissue.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43536574A | 1974-01-21 | 1974-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1494781A true GB1494781A (en) | 1977-12-14 |
Family
ID=23728099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1003/75A Expired GB1494781A (en) | 1974-01-21 | 1975-01-09 | Unsymmetrically substituted 1,4-dioxane-2,5-diones |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS50101367A (en) |
| AR (1) | AR205454A1 (en) |
| AT (1) | AT339902B (en) |
| BE (1) | BE824535A (en) |
| CA (1) | CA1052046A (en) |
| CH (1) | CH616417A5 (en) |
| CS (1) | CS196258B2 (en) |
| DD (1) | DD119259A5 (en) |
| DE (1) | DE2501448A1 (en) |
| DK (1) | DK15275A (en) |
| FR (1) | FR2279745A1 (en) |
| GB (1) | GB1494781A (en) |
| HU (1) | HU173692B (en) |
| IE (1) | IE40657B1 (en) |
| IN (1) | IN141151B (en) |
| IT (1) | IT1044114B (en) |
| NL (1) | NL7500689A (en) |
| PH (1) | PH12680A (en) |
| PL (1) | PL101805B1 (en) |
| RO (1) | RO70688A (en) |
| SE (1) | SE7500594L (en) |
| ZA (1) | ZA7538B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873371A1 (en) * | 2004-07-26 | 2006-01-27 | Sod Conseils Rech Applic | NEW METHOD OF SYNTHESIS OF 2,5 DIOXANE 1,4 DIONES |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56157422A (en) * | 1980-05-07 | 1981-12-04 | Mitsui Toatsu Chem Inc | Acetylated polyglycolic acid and preparation thereof |
| DE3778111D1 (en) * | 1986-10-24 | 1992-05-14 | Boehringer Ingelheim Kg | METHOD FOR PRODUCING AND CLEANING THERMOLABILE COMPOUNDS. |
| JPH02500593A (en) * | 1987-06-16 | 1990-03-01 | ベーリンガー インゲルハイム コマンディットゲゼルシャフト | Meso-lactide and its manufacturing method |
| EP0339882A1 (en) * | 1988-04-27 | 1989-11-02 | MITSUI TOATSU CHEMICALS, Inc. | Process for the production of lactide |
| DE4321355A1 (en) * | 1993-06-26 | 1995-01-05 | Basf Ag | Polylactide with long chain branches |
| DE4440095A1 (en) * | 1994-11-10 | 1996-05-15 | Braun B Surgical Gmbh | Surgical sutures, their use in surgery, and methods of making them |
| ATE212062T1 (en) | 1996-02-08 | 2002-02-15 | Oekologische Technologie Und S | METHOD FOR PRODUCING ORGANIC AMINIUM LACTATES AND THE USE THEREOF FOR PRODUCING DILACTIDE |
| WO2007133783A1 (en) * | 2006-05-15 | 2007-11-22 | Tyco Healthcare Group Lp | Halogenated cyclic lactones and polymers made therefrom |
| FI3392252T3 (en) | 2011-08-23 | 2024-01-08 | Libertas Bio Inc | Pyrimido- pyridazinone compounds and use thereof |
| RS57845B1 (en) * | 2012-02-09 | 2018-12-31 | Novus Int Inc | Heteroatom containing cyclic dimers |
-
1974
- 1974-12-24 CA CA216,765A patent/CA1052046A/en not_active Expired
- 1974-12-31 IE IE2680/74A patent/IE40657B1/en unknown
-
1975
- 1975-01-01 AR AR257269A patent/AR205454A1/en active
- 1975-01-02 ZA ZA00750038A patent/ZA7538B/en unknown
- 1975-01-03 IN IN23/CAL/1975A patent/IN141151B/en unknown
- 1975-01-09 GB GB1003/75A patent/GB1494781A/en not_active Expired
- 1975-01-10 PH PH16698A patent/PH12680A/en unknown
- 1975-01-13 RO RO7581101A patent/RO70688A/en unknown
- 1975-01-14 CS CS75253A patent/CS196258B2/en unknown
- 1975-01-15 DE DE19752501448 patent/DE2501448A1/en not_active Withdrawn
- 1975-01-20 DD DD183736A patent/DD119259A5/xx unknown
- 1975-01-20 CH CH61375A patent/CH616417A5/en not_active IP Right Cessation
- 1975-01-20 HU HU75AE436A patent/HU173692B/en unknown
- 1975-01-20 BE BE152494A patent/BE824535A/en unknown
- 1975-01-20 AT AT39075A patent/AT339902B/en not_active IP Right Cessation
- 1975-01-20 DK DK15275*BA patent/DK15275A/da not_active Application Discontinuation
- 1975-01-20 PL PL1975177442A patent/PL101805B1/en unknown
- 1975-01-20 IT IT47760/75A patent/IT1044114B/en active
- 1975-01-20 SE SE7500594A patent/SE7500594L/xx unknown
- 1975-01-21 FR FR7501823A patent/FR2279745A1/en active Granted
- 1975-01-21 JP JP50008413A patent/JPS50101367A/ja active Pending
- 1975-01-21 NL NL7500689A patent/NL7500689A/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873371A1 (en) * | 2004-07-26 | 2006-01-27 | Sod Conseils Rech Applic | NEW METHOD OF SYNTHESIS OF 2,5 DIOXANE 1,4 DIONES |
Also Published As
| Publication number | Publication date |
|---|---|
| RO70688A (en) | 1982-05-10 |
| NL7500689A (en) | 1975-07-23 |
| AR205454A1 (en) | 1976-05-07 |
| HU173692B (en) | 1979-07-28 |
| CS196258B2 (en) | 1980-03-31 |
| CH616417A5 (en) | 1980-03-31 |
| JPS50101367A (en) | 1975-08-11 |
| AT339902B (en) | 1977-11-10 |
| ATA39075A (en) | 1977-03-15 |
| IE40657L (en) | 1975-07-21 |
| DE2501448A1 (en) | 1975-07-24 |
| FR2279745B1 (en) | 1978-02-24 |
| IE40657B1 (en) | 1979-07-18 |
| DD119259A5 (en) | 1976-04-12 |
| ZA7538B (en) | 1976-01-28 |
| IT1044114B (en) | 1980-03-20 |
| PL101805B1 (en) | 1979-02-28 |
| FR2279745A1 (en) | 1976-02-20 |
| AU7708575A (en) | 1976-07-08 |
| DK15275A (en) | 1975-09-15 |
| BE824535A (en) | 1975-07-22 |
| PH12680A (en) | 1979-07-18 |
| IN141151B (en) | 1977-01-22 |
| SE7500594L (en) | 1975-07-22 |
| CA1052046A (en) | 1979-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |