GB1480975A - Thiazole derivatives - Google Patents
Thiazole derivativesInfo
- Publication number
- GB1480975A GB1480975A GB20147/75A GB2014775A GB1480975A GB 1480975 A GB1480975 A GB 1480975A GB 20147/75 A GB20147/75 A GB 20147/75A GB 2014775 A GB2014775 A GB 2014775A GB 1480975 A GB1480975 A GB 1480975A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiazole derivatives
- synthesis
- natural prostaglandins
- novel
- carbalkoxyheptanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007979 thiazole derivatives Chemical class 0.000 title abstract 2
- 150000003180 prostaglandins Chemical group 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
- E21D23/00—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor
- E21D23/0004—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor along the working face
- E21D23/0017—Pile type supports
- E21D23/0021—Pile type supports comprising two walking elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
- E21D23/00—Mine roof supports for step- by- step movement, e.g. in combination with provisions for shifting of conveyors, mining machines, or guides therefor
- E21D23/04—Structural features of the supporting construction, e.g. linking members between adjacent frames or sets of props; Means for counteracting lateral sliding on inclined floor
- E21D23/0409—Aligning or guiding means for the supports or for the constitutive parts of the supports
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mining & Mineral Resources (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Geology (AREA)
- Architecture (AREA)
- Structural Engineering (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel thiazole derivatives with prostaglandin side chains, of the formula I are prepared starting from acetoacetic ester and 7-carbalkoxyheptanoyl chloride in a 13-stage synthesis, where the individual stages comprise known methods. The synthesis is described in the Patent Claim. The novel compounds exert on certain organs an effect which is similar to but more selective than that of the natural prostaglandins. In addition, they inhibit the activity of those enzymes which promote breakdown of the natural prostaglandins in the organism.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUGO1269A HU169072B (en) | 1974-05-14 | 1974-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1480975A true GB1480975A (en) | 1977-07-27 |
Family
ID=10996766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB20147/75A Expired GB1480975A (en) | 1974-05-14 | 1975-05-13 | Thiazole derivatives |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5163171A (en) |
AT (1) | AT351525B (en) |
BE (1) | BE828994A (en) |
CA (1) | CA1053683A (en) |
CH (1) | CH613959A5 (en) |
DD (1) | DD117462A1 (en) |
DE (1) | DE2521517A1 (en) |
DK (1) | DK144065C (en) |
FR (1) | FR2270872B1 (en) |
GB (1) | GB1480975A (en) |
HU (1) | HU169072B (en) |
NL (1) | NL7505585A (en) |
PL (1) | PL107592B1 (en) |
SE (1) | SE421918B (en) |
SU (1) | SU755197A3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022794A (en) * | 1976-05-24 | 1977-05-10 | Merck & Co., Inc. | Novel analogs of prostaglandins with 4-oxo-thiazolidinyl nucleus and method of preparation thereof |
DE2946810A1 (en) * | 1979-11-20 | 1981-05-27 | A. Nattermann & Cie GmbH, 5000 Köln | ALKENYL-THIENYL-ALKANIC CARBONIC ACID AND ITS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME |
-
1974
- 1974-05-14 HU HUGO1269A patent/HU169072B/hu unknown
-
1975
- 1975-05-12 CH CH603275A patent/CH613959A5/en not_active IP Right Cessation
- 1975-05-12 FR FR7514625A patent/FR2270872B1/fr not_active Expired
- 1975-05-13 GB GB20147/75A patent/GB1480975A/en not_active Expired
- 1975-05-13 AT AT366775A patent/AT351525B/en not_active IP Right Cessation
- 1975-05-13 BE BE156281A patent/BE828994A/en unknown
- 1975-05-13 NL NL7505585A patent/NL7505585A/en not_active Application Discontinuation
- 1975-05-13 SU SU752137627A patent/SU755197A3/en active
- 1975-05-13 DK DK210175A patent/DK144065C/en active
- 1975-05-13 SE SE7505494A patent/SE421918B/en unknown
- 1975-05-14 CA CA226,932A patent/CA1053683A/en not_active Expired
- 1975-05-14 PL PL1975180338A patent/PL107592B1/en unknown
- 1975-05-14 DD DD186029A patent/DD117462A1/xx unknown
- 1975-05-14 DE DE19752521517 patent/DE2521517A1/en not_active Withdrawn
- 1975-05-14 JP JP50057156A patent/JPS5163171A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
SE421918B (en) | 1982-02-08 |
JPS5163171A (en) | 1976-06-01 |
SU755197A3 (en) | 1980-08-07 |
DE2521517A1 (en) | 1975-11-27 |
DK144065C (en) | 1982-05-17 |
BE828994A (en) | 1975-09-01 |
DK210175A (en) | 1975-11-15 |
AU8113575A (en) | 1976-11-18 |
DK144065B (en) | 1981-11-30 |
FR2270872B1 (en) | 1978-10-06 |
HU169072B (en) | 1976-09-28 |
CH613959A5 (en) | 1979-10-31 |
DD117462A1 (en) | 1976-01-12 |
PL107592B1 (en) | 1980-02-29 |
AT351525B (en) | 1979-07-25 |
NL7505585A (en) | 1975-11-18 |
CA1053683A (en) | 1979-05-01 |
FR2270872A1 (en) | 1975-12-12 |
ATA366775A (en) | 1979-01-15 |
SE7505494L (en) | 1975-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
746 | Register noted 'licences of right' (sect. 46/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |