GB1472667A - Nucleosidic antibiotic and derivatives thereof - Google Patents
Nucleosidic antibiotic and derivatives thereofInfo
- Publication number
- GB1472667A GB1472667A GB1720675A GB1720675A GB1472667A GB 1472667 A GB1472667 A GB 1472667A GB 1720675 A GB1720675 A GB 1720675A GB 1720675 A GB1720675 A GB 1720675A GB 1472667 A GB1472667 A GB 1472667A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- phosphono
- group
- substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- -1 nitro, hydroxy, amino Chemical group 0.000 abstract 2
- 230000026731 phosphorylation Effects 0.000 abstract 2
- 238000006366 phosphorylation reaction Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241001304058 Streptomyces platensis subsp. clarensis Species 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 abstract 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/903—Streptomyces platensis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
1472667 1-Substituted 5-methyl-5-azauracils UPJOHN CO 25 April 1975 [20 May 1974] 17206/75 Headings C2C and C2P Novel 1-substituted 5-methyl-5-azauracils of the general formula wherein each of R and R<SP>1</SP> is a hydrogen atom, or each of R and R<SP>1</SP> is a C 2-18 hydrocarboncarboxylic acyl group, optionally substituted by halo, nitro, hydroxy, amino, cyano or thiocyanato, or C 2-8 alkoxycarbonyl, or one of R and R<SP>1</SP> is hydrogen and the other is phosphono or optionally substituted hydrocarbon-carboxylic acyl or alkoxycarbonyl as defined above, are prepared (a) when each of R and R<SP>1</SP> is a hydrogen atom, by cultivating Streptomyces platensis var. clarensis, having the identifying features of NRRL 8035, in an aqueous nutrient medium containing C and N sources under submerged aerobic conditions until substantial antibiotic activity is imparted to the medium; (b) when neither R nor R<SP>1</SP> is a phosphono group and at least one of them is other than hydrogen, by acylation of the product of (a); (c) when R is hydrogen and R<SP>1</SP> is a phosphono group, by phosphorylation of the product of (a); and (d) when R is a phosphono or acyl group and R<SP>1</SP> is a hydrogen atom, by phosphorylation or acylation of the 51-trityl derivative of the product of (a) and removal of the trityl group by mild acid hydrolysis. Antibacterial compositions comprise, as active ingredient, a 1-substituted 5-methyl-5-azauracil of the above general formula, together with a pharmaceutically acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US471322A US3907779A (en) | 1974-05-20 | 1974-05-20 | 5,6 Dihydro-5-azathymidine and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1472667A true GB1472667A (en) | 1977-05-04 |
Family
ID=23871167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1720675A Expired GB1472667A (en) | 1974-05-20 | 1975-04-25 | Nucleosidic antibiotic and derivatives thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3907779A (en) |
| JP (2) | JPS5851759B2 (en) |
| BE (1) | BE829268A (en) |
| CA (1) | CA1037889A (en) |
| DE (1) | DE2521197C2 (en) |
| FR (1) | FR2271838B1 (en) |
| GB (1) | GB1472667A (en) |
| NL (1) | NL7505708A (en) |
| ZA (1) | ZA752598B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022889A (en) * | 1974-05-20 | 1977-05-10 | The Upjohn Company | Therapeutic compositions of antibiotic U-44,590 and methods for using the same |
| US3988314A (en) * | 1975-10-10 | 1976-10-26 | The Upjohn Company | Compound U-50,228, derivatives thereof, and processes for preparation |
| US4171431A (en) * | 1976-08-19 | 1979-10-16 | The Upjohn Company | Nucleosides and process |
| US4140850A (en) * | 1977-08-29 | 1979-02-20 | The Upjohn Company | 2,2'-Anhydrotriazine nucleosides and process for preparing the same |
| US4239753A (en) * | 1978-12-12 | 1980-12-16 | The Upjohn Company | Composition of matter and process |
| US4477442A (en) * | 1978-12-12 | 1984-10-16 | The Upjohn Company | Composition of matter and process |
| US4423212A (en) * | 1980-12-18 | 1983-12-27 | The Upjohn Company | Nucleosides and process |
| JPH0411748Y2 (en) * | 1984-11-20 | 1992-03-24 | ||
| JPH04150878A (en) * | 1990-10-16 | 1992-05-25 | Goerling George | Training apparatus for golf-swing |
| AU649116B2 (en) * | 1991-03-27 | 1994-05-12 | Sankyo Company Limited | New compounds, named the "Leustroducins", their preparation and their therapeutic uses |
| US5707491A (en) * | 1993-06-16 | 1998-01-13 | Ranpak Corporation | Paper strengthened with solubilized collagen and method |
| US5700354A (en) * | 1993-06-16 | 1997-12-23 | Ranpak Corp. | Paper strengthened with solubilized collagen and method |
| US5316942A (en) * | 1993-06-16 | 1994-05-31 | Battelle Memorial Institute | Process for the production of low-cost soluble high-molecular weight collagen |
| US5711853A (en) * | 1993-06-16 | 1998-01-27 | Ranpak Corp. | Paper strengthened with solubilized collagen and method |
| US20070207973A1 (en) * | 2002-09-24 | 2007-09-06 | Koronis Pharmaceuticals, Incorporated | 1,3,5-Triazines for Treatment of Viral Diseases |
| AU2003278904A1 (en) * | 2002-09-24 | 2004-04-19 | Kornis Pharmaceuticals, Incorporated | 1, 3, 5-triazines for treatment of viral diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300478A (en) * | 1965-06-01 | 1967-01-24 | Upjohn Co | Arabinofuranosyl 2', 5'-and 3'-5'-dinucleoside phosphates and process therefor |
| US3457253A (en) * | 1965-06-01 | 1969-07-22 | Upjohn Co | 5',5'-di-(ara)-nucleoside phosphates |
-
1974
- 1974-05-20 US US471322A patent/US3907779A/en not_active Expired - Lifetime
-
1975
- 1975-04-22 ZA ZA00752598A patent/ZA752598B/en unknown
- 1975-04-24 CA CA225,567A patent/CA1037889A/en not_active Expired
- 1975-04-25 GB GB1720675A patent/GB1472667A/en not_active Expired
- 1975-05-01 JP JP50052100A patent/JPS5851759B2/en not_active Expired
- 1975-05-13 DE DE2521197A patent/DE2521197C2/en not_active Expired
- 1975-05-15 NL NL7505708A patent/NL7505708A/en not_active Application Discontinuation
- 1975-05-16 FR FR7515539A patent/FR2271838B1/fr not_active Expired
- 1975-05-20 BE BE156516A patent/BE829268A/en not_active IP Right Cessation
-
1983
- 1983-07-14 JP JP58127066A patent/JPS5948072A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2521197A1 (en) | 1975-12-11 |
| JPS5948072A (en) | 1984-03-19 |
| ZA752598B (en) | 1976-03-31 |
| JPS50148590A (en) | 1975-11-28 |
| NL7505708A (en) | 1975-11-24 |
| FR2271838A1 (en) | 1975-12-19 |
| DE2521197C2 (en) | 1984-09-13 |
| CA1037889A (en) | 1978-09-05 |
| AU8057975A (en) | 1976-11-04 |
| US3907779A (en) | 1975-09-23 |
| JPS5851759B2 (en) | 1983-11-18 |
| FR2271838B1 (en) | 1978-10-06 |
| BE829268A (en) | 1975-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |