GB1467740A - Derivatives of inbutylamine and processes for preparing the same - Google Patents
Derivatives of inbutylamine and processes for preparing the sameInfo
- Publication number
- GB1467740A GB1467740A GB2833676A GB2833676A GB1467740A GB 1467740 A GB1467740 A GB 1467740A GB 2833676 A GB2833676 A GB 2833676A GB 2833676 A GB2833676 A GB 2833676A GB 1467740 A GB1467740 A GB 1467740A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- acid
- general formula
- reacting
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/08—Monoamines containing alkyl groups having a different number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/126—Acids containing more than four carbon atoms
- C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1467740 1,1-Dialkyl-n-butylamines LABAZ 15 May 1975 [20 May 1974] 28336/76 Divided out of 1467739 Heading C2C Novel 1,1-dialkyl-n-butylamines of the general formula wherein R 1 is an ethyl or n-propyl group and R 2 is (a) an ethyl, isopropyl, isobutyl or tert. butyl group when R 1 is a n-propyl group and (b) a n-butyl or isobutyl group when R 1 is an ethyl group, and pharmaceutically acceptable acid addition salts thereof are prepared by treating an isocyanate of formamide of the general formula wherein A is -N=C=O or -NHCHO, with a strong acid in an appropriate medium, optionally treating the resulting acid addition salt with a base and optionally reacting the resulting free base with an acid to form a pharmaceutically acceptable salt. Novel 1,1 - di - n - propyl - n - butylamine acid fumarate is prepared by reacting the corresponding amine (1 mole) with fumaric acid (1 mole), the amine being prepared analogously to the amines (I). Isooyanates (II) are prepared by reacting an amide of the general formula with chlorine or bromine in an alkaline medium. 1,1 - Di - n - propyl - n - butyl isocyanate is prepared analogously. Formamides (II) are prepared by heating an alcohol of the general formula with an alkali metal cyanide in the presence of an acid. Alcohols (IV) are prepared by reacting an alkyl lithium with an appropriate dialkyl ketone in an anhydrous ether medium. Acids of the general formula are prepared by treating an alcohol (IV) with formic acid in a sulphuric acid medium.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE144519A BE815273A (en) | 1974-05-20 | 1974-05-20 | METHYLAMINE ACTIVE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1467740A true GB1467740A (en) | 1977-03-23 |
Family
ID=3842664
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2833676A Expired GB1467740A (en) | 1974-05-20 | 1975-05-15 | Derivatives of inbutylamine and processes for preparing the same |
| GB2073875A Expired GB1467739A (en) | 1974-05-20 | 1975-05-15 | Therapeutic compositions containing methylamine derivatives or their salts |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2073875A Expired GB1467739A (en) | 1974-05-20 | 1975-05-15 | Therapeutic compositions containing methylamine derivatives or their salts |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS569498B2 (en) |
| AR (1) | AR208548A1 (en) |
| AT (1) | AT341488B (en) |
| BE (1) | BE815273A (en) |
| CA (1) | CA1048549A (en) |
| CH (1) | CH605606A5 (en) |
| DE (1) | DE2522218C3 (en) |
| DK (1) | DK145779C (en) |
| ES (1) | ES437790A1 (en) |
| FI (1) | FI61182C (en) |
| FR (1) | FR2271811B1 (en) |
| GB (2) | GB1467740A (en) |
| HU (1) | HU173890B (en) |
| IE (1) | IE41032B1 (en) |
| IT (1) | IT1049427B (en) |
| NL (1) | NL172120C (en) |
| NO (1) | NO139733C (en) |
| OA (1) | OA05004A (en) |
| SE (1) | SE434262B (en) |
| SU (1) | SU1292666A3 (en) |
| YU (1) | YU39318B (en) |
| ZA (1) | ZA752863B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114235991A (en) * | 2021-11-27 | 2022-03-25 | 山东省烟台市农业科学研究院 | High performance liquid chromatography for determining sec-butylamine content |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201725A (en) * | 1974-05-20 | 1980-05-06 | Labaz | Secondary amines |
| GR61148B (en) * | 1976-06-03 | 1978-09-27 | Labaz | Preparation process of active methylamine derivatives |
| JPS5427369A (en) * | 1977-08-01 | 1979-03-01 | Hitachi Ltd | Pattern formation method |
| FR2470758A1 (en) | 1979-12-07 | 1981-06-12 | Sanofi Sa | METHOD FOR FIXING ALKYL GROUPS ON A CARBONIC CHAIN CARRYING A FUNCTIONAL GROUP |
| AU6497200A (en) * | 1999-07-30 | 2001-02-19 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
-
1974
- 1974-05-20 ES ES437790A patent/ES437790A1/en not_active Expired
- 1974-05-20 BE BE144519A patent/BE815273A/en not_active IP Right Cessation
-
1975
- 1975-04-30 IE IE974/75A patent/IE41032B1/en unknown
- 1975-05-02 ZA ZA00752863A patent/ZA752863B/en unknown
- 1975-05-09 HU HU75LA865A patent/HU173890B/en unknown
- 1975-05-14 YU YU1226/75A patent/YU39318B/en unknown
- 1975-05-15 SE SE7505606A patent/SE434262B/en not_active IP Right Cessation
- 1975-05-15 GB GB2833676A patent/GB1467740A/en not_active Expired
- 1975-05-15 CA CA75227044A patent/CA1048549A/en not_active Expired
- 1975-05-15 FR FR7515118A patent/FR2271811B1/fr not_active Expired
- 1975-05-15 GB GB2073875A patent/GB1467739A/en not_active Expired
- 1975-05-15 AT AT371575A patent/AT341488B/en not_active IP Right Cessation
- 1975-05-16 DK DK216575A patent/DK145779C/en active
- 1975-05-16 NL NLAANVRAGE7505853,A patent/NL172120C/en not_active IP Right Cessation
- 1975-05-16 NO NO75751771A patent/NO139733C/en unknown
- 1975-05-17 OA OA55502A patent/OA05004A/en unknown
- 1975-05-19 AR AR258840A patent/AR208548A1/en active
- 1975-05-20 IT IT23511/75A patent/IT1049427B/en active
- 1975-05-20 CH CH643975A patent/CH605606A5/fr not_active IP Right Cessation
- 1975-05-20 JP JP6086675A patent/JPS569498B2/ja not_active Expired
- 1975-05-20 FI FI751468A patent/FI61182C/en not_active IP Right Cessation
- 1975-05-20 DE DE2522218A patent/DE2522218C3/en not_active Expired
-
1983
- 1983-03-25 SU SU833567049A patent/SU1292666A3/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114235991A (en) * | 2021-11-27 | 2022-03-25 | 山东省烟台市农业科学研究院 | High performance liquid chromatography for determining sec-butylamine content |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |