GB1456946A - 6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines - Google Patents

6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines

Info

Publication number
GB1456946A
GB1456946A GB4428475A GB4428475A GB1456946A GB 1456946 A GB1456946 A GB 1456946A GB 4428475 A GB4428475 A GB 4428475A GB 4428475 A GB4428475 A GB 4428475A GB 1456946 A GB1456946 A GB 1456946A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
acid addition
acceptable acid
formula iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4428475A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1456946A publication Critical patent/GB1456946A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Compounds of the formula III, in which R1 denotes hydrogen or chlorine, or their pharmaceutically acceptable acid addition salts are obtained by reacting a 2-thiabenzodiazepine of the formula I, preferably in an inert organic solvent, with a reagent of the formula IV, preferably at a temperature between 60 and 120 DEG C. After conventional working up of the compound of the formula II obtained, this is cyclised using a concentrated acid and the compound of the formula III is isolated. If the product is treated with a pharmacologically acceptable acid, the corresponding acid addition salt is obtained. The novel compounds have sedative and tranquillising action and can be administered in compositions which are formulated in a customary pharmacological manner. <IMAGE>
GB4428475A 1974-11-15 1975-10-28 6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines Expired GB1456946A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52423474A 1974-11-15 1974-11-15
US58445875A 1975-06-06 1975-06-06

Publications (1)

Publication Number Publication Date
GB1456946A true GB1456946A (en) 1976-12-01

Family

ID=27061425

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4428475A Expired GB1456946A (en) 1974-11-15 1975-10-28 6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines

Country Status (5)

Country Link
JP (1) JPS5176414A (en)
CH (1) CH617937A5 (en)
DE (1) DE2547652A1 (en)
FR (1) FR2290905A1 (en)
GB (1) GB1456946A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3332830A1 (en) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. USE OF BENZODIAZEPINES TO COMBAT OR TREAT PANIC CONDITIONS
CA2071092A1 (en) * 1991-06-14 1992-12-15 Roger M. Freidinger 1,4-benzodiazepines with 5-membered heterocyclic rings
PT801651E (en) * 1995-01-06 2001-12-28 Hoffmann La Roche HYDROXIMETHYL-IMIDAZODIAZEPINS AND ITS ESTERS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2308280A1 (en) * 1971-11-15 1973-09-06 Ciba Geigy Ag PROCESS FOR THE PRODUCTION OF NEW DIAZEPIN DERIVATIVES
US3763179A (en) * 1972-05-05 1973-10-02 Upjohn Co 2-imidazol-1-yl benzophenones
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants

Also Published As

Publication number Publication date
FR2290905B1 (en) 1978-07-28
JPS5176414A (en) 1976-07-02
DE2547652A1 (en) 1976-05-20
CH617937A5 (en) 1980-06-30
FR2290905A1 (en) 1976-06-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee