GB1446980A - A-aminooxy-carboxylic acid hydrazides - Google Patents

A-aminooxy-carboxylic acid hydrazides

Info

Publication number
GB1446980A
GB1446980A GB5027274A GB5027274A GB1446980A GB 1446980 A GB1446980 A GB 1446980A GB 5027274 A GB5027274 A GB 5027274A GB 5027274 A GB5027274 A GB 5027274A GB 1446980 A GB1446980 A GB 1446980A
Authority
GB
United Kingdom
Prior art keywords
radical
substituted
group
aminooxycarbohydrazide
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5027274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1446980A publication Critical patent/GB1446980A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
    • C07D307/73—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by amino or imino, or substituted amino or imino radicals

Abstract

Substituted alpha -aminooxycarbohydrazide derivatives of the formula I <IMAGE> are obtained by reacting an alpha -aminooxycarbohydrazide with a compound of the general formula X = O. The substituents have the following meaning: X is a cycloalkylidene radical or a methylene group which is substituted by an alkyl radical with 1-5 carbon atoms and/or phenyl or furyl radical which is optionally substituted by halogen, hydroxyl, nitro and/or amino groups; R is hydrogen or a benzyl radical Y is hydrogen Z is an acyl radical derived from a pyridinecarboxylic acid or Y and Z together are one of the substituents which X can represent. The compounds are valuable tuberculostatics. Compounds substituted on the hydrazide group by isonicotinoyl or 5-nitrofurfurylidene group are particularly effective.
GB5027274A 1973-11-29 1974-11-20 A-aminooxy-carboxylic acid hydrazides Expired GB1446980A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI530A HU167365B (en) 1973-11-29 1973-11-29

Publications (1)

Publication Number Publication Date
GB1446980A true GB1446980A (en) 1976-08-18

Family

ID=11000941

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5027274A Expired GB1446980A (en) 1973-11-29 1974-11-20 A-aminooxy-carboxylic acid hydrazides

Country Status (13)

Country Link
JP (2) JPS5951537B2 (en)
AT (1) AT340920B (en)
BE (1) BE822767A (en)
CA (1) CA1018171A (en)
CH (2) CH612926A5 (en)
CS (1) CS199568B2 (en)
DD (1) DD118874A5 (en)
DE (1) DE2455353C3 (en)
FR (1) FR2252845B1 (en)
GB (1) GB1446980A (en)
HU (1) HU167365B (en)
NL (1) NL7415589A (en)
SU (2) SU574146A3 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7414037B2 (en) 2004-03-30 2008-08-19 The Regents Of The University Of California Hydrazide-containing CFTR inhibitor compounds and uses thereof
EP2164326A1 (en) * 2007-05-31 2010-03-24 Euro-Celtique, S.A. Amide compounds and the use thereof
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US8236838B2 (en) 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8283351B2 (en) 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US8518934B2 (en) 2008-06-11 2013-08-27 Shonogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
US8552067B2 (en) 2006-12-22 2013-10-08 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor
US8563732B2 (en) 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
WO2014201446A2 (en) * 2013-06-14 2014-12-18 Hellmich Mark Use of hydrogen sulfide synthesis inhibitors for the therapy of colorectal cancers

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE52765T1 (en) * 1984-10-18 1990-06-15 Shell Int Research ALPHA AMINOOXY C4 ALKANOIC ACIDS AND ESTERS.
JPH0317434Y2 (en) * 1986-03-11 1991-04-12
US5002605A (en) * 1988-12-21 1991-03-26 Ici Americas Inc. Alkylidine aminooxyamide compounds useful in controlling undesirable vegetation
CN102276593B (en) * 2011-07-01 2013-10-30 华东师范大学 Heterocyclic ketene hydrazone compound and preparation method as well as tubercle bacillus resistant application

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7414037B2 (en) 2004-03-30 2008-08-19 The Regents Of The University Of California Hydrazide-containing CFTR inhibitor compounds and uses thereof
US7888332B2 (en) 2004-03-30 2011-02-15 The Regents Of The University Of California Hydrazide-containing CFTR inhibitor compounds and uses thereof
US8552067B2 (en) 2006-12-22 2013-10-08 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor
US8283351B2 (en) 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
EP2164326A4 (en) * 2007-05-31 2012-05-09 Euro Celtique Sa Amide compounds and the use thereof
EP2164326A1 (en) * 2007-05-31 2010-03-24 Euro-Celtique, S.A. Amide compounds and the use thereof
US8563732B2 (en) 2007-05-31 2013-10-22 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US8236838B2 (en) 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8796321B2 (en) 2008-04-21 2014-08-05 Path Drug Solutions Compounds, compositions and methods comprising oxadiazole derivatives
US8518934B2 (en) 2008-06-11 2013-08-27 Shonogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
WO2014201446A2 (en) * 2013-06-14 2014-12-18 Hellmich Mark Use of hydrogen sulfide synthesis inhibitors for the therapy of colorectal cancers
WO2014201446A3 (en) * 2013-06-14 2015-02-05 Hellmich Mark Use of hydrogen sulfide synthesis inhibitors for the therapy of colorectal cancers
US10335382B2 (en) 2013-06-14 2019-07-02 The Board Of Regents Of The University Of Texas System Use of hydrogen sulfide synthesis inhibitors for cancer therapy

Also Published As

Publication number Publication date
SU608472A3 (en) 1978-05-25
BE822767A (en) 1975-03-14
JPS5951537B2 (en) 1984-12-14
JPS57192365A (en) 1982-11-26
CS199568B2 (en) 1980-07-31
CH614954A5 (en) 1979-12-28
CH612926A5 (en) 1979-08-31
CA1018171A (en) 1977-09-27
FR2252845B1 (en) 1978-07-21
HU167365B (en) 1975-09-27
JPS5084523A (en) 1975-07-08
ATA940574A (en) 1977-05-15
SU574146A3 (en) 1977-09-25
AT340920B (en) 1978-01-10
DE2455353C3 (en) 1979-08-09
DD118874A5 (en) 1976-03-20
DE2455353A1 (en) 1975-06-05
DE2455353B2 (en) 1978-12-07
JPS5953264B2 (en) 1984-12-24
NL7415589A (en) 1975-06-02
FR2252845A1 (en) 1975-06-27

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee