GB1436357A - Tri-iodo benzene derivatives and their use as x-ray contrast - Google Patents
Tri-iodo benzene derivatives and their use as x-ray contrastInfo
- Publication number
- GB1436357A GB1436357A GB5683173A GB5683173A GB1436357A GB 1436357 A GB1436357 A GB 1436357A GB 5683173 A GB5683173 A GB 5683173A GB 5683173 A GB5683173 A GB 5683173A GB 1436357 A GB1436357 A GB 1436357A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- tri
- prepared
- ray contrast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RIWAPWDHHMWTRA-UHFFFAOYSA-N 1,2,3-triiodobenzene Chemical class IC1=CC=CC(I)=C1I RIWAPWDHHMWTRA-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- QZRGKCOWNLSUDK-UHFFFAOYSA-N Iodochlorine Chemical compound ICl QZRGKCOWNLSUDK-UHFFFAOYSA-N 0.000 abstract 1
- -1 Substituted Chemical class 0.000 abstract 1
- LUTSRLYCMSCGCS-BWOMAWGNSA-N [(3s,8r,9s,10r,13s)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,16-decahydrocyclopenta[a]phenanthren-3-yl] acetate Chemical compound C([C@@H]12)C[C@]3(C)C(=O)CC=C3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)C)C1 LUTSRLYCMSCGCS-BWOMAWGNSA-N 0.000 abstract 1
- 150000001448 anilines Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- VVRWYSXBSGZWPI-UHFFFAOYSA-N methyl 3-amino-5-[ethyl(hydroxy)carbamoyl]benzoate Chemical compound COC(C1=CC(=CC(=C1)C(N(O)CC)=O)N)=O VVRWYSXBSGZWPI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
Abstract
1436357 Substituted - N - gluconyl anilines LABORATOIRES ANDRE GUERBET 27 Nov 1974 [7 Dec 1973] 56831/73 Heading C2C [Also in Division A5] Novel compounds of Formula I wherein R<SP>1</SP> is H or C 1 -C 4 alkyl, R<SP>2</SP> is where each of R<SP>4</SP> and R<SP>6</SP> is H C 1 -C 4 alkyl or C 1 -C 4 hydroxyalkyl, R<SP>3</SP> is CONR<SP>6</SP>R<SP>7</SP> where each of R<SP>6</SP> and R<SP>7</SP> is as for R<SP>4</SP> and R<SP>5</SP> or in a radical of formula (II) wherein R<SP>7</SP> is H or C 1 -C 4 alkyl and R<SP>8</SP> is a C 1 -C 4 alkyl are prepared by action of an acid halide of formula HalCO-(CHOH) 5 H or a penta-acylated derivative is reacted with a compound of Formula III 2,4,6 - Tri - iodo - 3 - (N - methyl - carbamyl)- 5 - (N - hydroxyethylcarbamyl)- analine is prepared by reaction of iodine chloride on the dehalo compound obtained from methylamine and 3 - amino - 5 - (N - hydroxy - ethylcarbamyl)- benzoic acid methyl ester prepared from the acid and methanol.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5683173A GB1436357A (en) | 1973-12-07 | 1973-12-07 | Tri-iodo benzene derivatives and their use as x-ray contrast |
| CH1548874A CH593916A5 (en) | 1973-12-07 | 1974-11-21 | |
| FR7438334A FR2253509B1 (en) | 1973-12-07 | 1974-11-21 | |
| DE19742456685 DE2456685C3 (en) | 1973-12-07 | 1974-11-30 | Gluconic acid-2, 4, 6-trijodanilide, process for their preparation and their use as a contrast agent for X-rays |
| SE7415042A SE410966B (en) | 1973-12-07 | 1974-12-02 | IODED BENZENE DERIVATIVES FOR USE AS CONTRAST MEDIA FOR RADIOGRAPHY |
| DK630974AA DK137311B (en) | 1973-12-07 | 1974-12-04 | Triiodobenzene derivatives for use as X-ray contrast agents. |
| ES432566A ES432566A1 (en) | 1973-12-07 | 1974-12-04 | Tri-iodo benzene derivatives and their use as x-ray contrast |
| NO744400A NO139128C (en) | 1973-12-07 | 1974-12-05 | IODENZENE DERIVATIVES FOR USE IN X-RAY CONTRAST MEASURES |
| BR10247/74A BR7410247A (en) | 1973-12-07 | 1974-12-06 | PROCESS FOR PREPARING NEW BENZENE TRIIODATED DERIVATIVES |
| NL7415951A NL7415951A (en) | 1973-12-07 | 1974-12-06 | PROCESS FOR PREPARING NEW IODIUM DERIVES OF THE BENZENE SERIES. |
| BE151223A BE823029A (en) | 1973-12-07 | 1974-12-06 | OPACIFYING PRODUCT FOR RADIOGRAPHY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5683173A GB1436357A (en) | 1973-12-07 | 1973-12-07 | Tri-iodo benzene derivatives and their use as x-ray contrast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1436357A true GB1436357A (en) | 1976-05-19 |
Family
ID=10477658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5683173A Expired GB1436357A (en) | 1973-12-07 | 1973-12-07 | Tri-iodo benzene derivatives and their use as x-ray contrast |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE823029A (en) |
| BR (1) | BR7410247A (en) |
| CH (1) | CH593916A5 (en) |
| DK (1) | DK137311B (en) |
| ES (1) | ES432566A1 (en) |
| FR (1) | FR2253509B1 (en) |
| GB (1) | GB1436357A (en) |
| NL (1) | NL7415951A (en) |
| NO (1) | NO139128C (en) |
| SE (1) | SE410966B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364921A (en) | 1979-03-08 | 1982-12-21 | Schering, Aktiengesellschaft | Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125709A (en) * | 1974-10-04 | 1978-11-14 | Mallinckrodt, Inc. | Polyhydroxy-alkyl-3,5-disubstituted-2,4,6-triiodocarbanilates |
| GB1491129A (en) * | 1975-06-04 | 1977-11-09 | Guerbet Sa | Iodo-benzene derivatives and an x-ray contrast medium containing them |
| FR2512014A1 (en) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | BROMINATED COMPOUNDS FOR USE IN OPACIFYING PRODUCTS |
| FR2511871A1 (en) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | PROCESS FOR INCREASING THE TOLERANCE OF OPACIFYING PRODUCTS AND OPACIFYING PRODUCTS THUS OBTAINED |
-
1973
- 1973-12-07 GB GB5683173A patent/GB1436357A/en not_active Expired
-
1974
- 1974-11-21 FR FR7438334A patent/FR2253509B1/fr not_active Expired
- 1974-11-21 CH CH1548874A patent/CH593916A5/xx not_active IP Right Cessation
- 1974-12-02 SE SE7415042A patent/SE410966B/en unknown
- 1974-12-04 ES ES432566A patent/ES432566A1/en not_active Expired
- 1974-12-04 DK DK630974AA patent/DK137311B/en not_active IP Right Cessation
- 1974-12-05 NO NO744400A patent/NO139128C/en unknown
- 1974-12-06 BR BR10247/74A patent/BR7410247A/en unknown
- 1974-12-06 NL NL7415951A patent/NL7415951A/en not_active Application Discontinuation
- 1974-12-06 BE BE151223A patent/BE823029A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364921A (en) | 1979-03-08 | 1982-12-21 | Schering, Aktiengesellschaft | Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media |
Also Published As
| Publication number | Publication date |
|---|---|
| CH593916A5 (en) | 1977-12-30 |
| NO139128B (en) | 1978-10-02 |
| BR7410247A (en) | 1976-06-29 |
| DE2456685B2 (en) | 1976-02-26 |
| BE823029A (en) | 1975-06-06 |
| SE7415042L (en) | 1975-06-09 |
| NO139128C (en) | 1979-01-31 |
| ES432566A1 (en) | 1976-11-01 |
| NO744400L (en) | 1975-07-07 |
| DK137311B (en) | 1978-02-20 |
| FR2253509A1 (en) | 1975-07-04 |
| NL7415951A (en) | 1975-06-10 |
| DK137311C (en) | 1978-07-17 |
| DK630974A (en) | 1975-07-21 |
| FR2253509B1 (en) | 1979-08-10 |
| DE2456685A1 (en) | 1975-06-12 |
| SE410966B (en) | 1979-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |