GB1435662A - Bleomycin derivatives - Google Patents
Bleomycin derivativesInfo
- Publication number
- GB1435662A GB1435662A GB1233274A GB1233274A GB1435662A GB 1435662 A GB1435662 A GB 1435662A GB 1233274 A GB1233274 A GB 1233274A GB 1233274 A GB1233274 A GB 1233274A GB 1435662 A GB1435662 A GB 1435662A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bleomycin
- amino acid
- isotope
- march
- marked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Abstract
1435662 Bleomycin derivatives PHILIPS GLOEILAMPENFABRIEKEN NV 20 March 1974 [22 March 1973] 12332/74 Heading C2C Novel bleomycin derivatives consisting of bleomycin coupled via an amido group to an amino acid, the amino acid being marked by a radio-active isotope, are prepared (a) by reacting an amino acid or ester thereof, marked with a radio-active isotope, with bleomycin in an aqueous medium in the presence of a carbodiimide or glutare dialdehyde or (b) by iodizing bleomycin, linked via an amido group to an amino acid containing a phenolic group, with the iodine isotope <SP>123</SP>I, <SP>125</SP>I or <SP>131</SP>I so that at least one atom of the isotope is introduced into the phenyl nucleus of the phenolic group. Injectable compositions for diagnostic examination of tumours comprise a bleomycin derivative as defined above and a suitable liquid carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7310292A FR2222103B1 (en) | 1973-03-22 | 1973-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1435662A true GB1435662A (en) | 1976-05-12 |
Family
ID=9116691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1233274A Expired GB1435662A (en) | 1973-03-22 | 1974-03-20 | Bleomycin derivatives |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS5029575A (en) |
BE (1) | BE812590A (en) |
DE (1) | DE2413052A1 (en) |
FR (1) | FR2222103B1 (en) |
GB (1) | GB1435662A (en) |
NL (1) | NL7403640A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474746A (en) * | 1980-08-08 | 1984-10-02 | State University Of New York | Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7801908A (en) * | 1978-02-21 | 1979-08-23 | Philips Nv | SELENOMETHIONINE-75SE CONTAINING SOLUTION, INCLUDING A THIOL AS A STABILIZER. |
JPH0261549A (en) * | 1988-08-26 | 1990-03-01 | Nok Corp | Manufacture of glucose oxidase immobilized oxygen transmission film |
-
1973
- 1973-03-22 FR FR7310292A patent/FR2222103B1/fr not_active Expired
-
1974
- 1974-03-19 DE DE19742413052 patent/DE2413052A1/en active Pending
- 1974-03-19 NL NL7403640A patent/NL7403640A/xx active Search and Examination
- 1974-03-20 GB GB1233274A patent/GB1435662A/en not_active Expired
- 1974-03-20 JP JP49031093A patent/JPS5029575A/ja active Pending
- 1974-03-20 BE BE142244A patent/BE812590A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474746A (en) * | 1980-08-08 | 1984-10-02 | State University Of New York | Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
Also Published As
Publication number | Publication date |
---|---|
FR2222103B1 (en) | 1976-08-13 |
NL7403640A (en) | 1974-09-24 |
FR2222103A1 (en) | 1974-10-18 |
DE2413052A1 (en) | 1974-10-03 |
JPS5029575A (en) | 1975-03-25 |
BE812590A (en) | 1974-09-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |