GB1434044A - Immobilised pentacyclic triterpenes - Google Patents

Immobilised pentacyclic triterpenes

Info

Publication number
GB1434044A
GB1434044A GB3404073A GB3404073A GB1434044A GB 1434044 A GB1434044 A GB 1434044A GB 3404073 A GB3404073 A GB 3404073A GB 3404073 A GB3404073 A GB 3404073A GB 1434044 A GB1434044 A GB 1434044A
Authority
GB
United Kingdom
Prior art keywords
activated
reaction
hexanediamine
carrier
oleanolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3404073A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biorex Laboratories Ltd
Original Assignee
Biorex Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Laboratories Ltd filed Critical Biorex Laboratories Ltd
Priority to GB3404073A priority Critical patent/GB1434044A/en
Priority to DE19742434385 priority patent/DE2434385A1/en
Priority to JP49082662A priority patent/JPS5031021A/ja
Publication of GB1434044A publication Critical patent/GB1434044A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1434044 Resin-drug composites BIOREX LABORATORIES Ltd 2 July 1974 [17 July 1973] 34040/73 Headings C3A C3P C3R and C3U [Also in Divisions C2 and D1] The invention comprises pharmaceutically active pentacyclic triterpenes which have been immobilized by chemical attachment to a polymeric organic or inorganic carrier; and their preparation by reacting the triterpene with the carrier, either of which may be chemically activated as appropriate. Specified triterpenes are glycyrrhetinic, 3-dehydroglycyrrhetinic, oleanolic, 11-oxo-oleanolic and ursolic acids and the hemisuccinates, hemiglutarates and amides thereof, and hederagenin. The examples relate exclusively to glycyrrhetinic acid hemisuccinate which may be activated by reaction with isobutyl chloroformate. The carrier may be a polysaccharide, e.g. agarose, a cross-linked dextran, starch, cellulose or cellulose acetate, these being activated by successive reactions of the diol system thereof with cyanogen bromide and 1,6-hexanediamine (R = hexamethylene). The carrier may also be chloromethylated "hydrocarbon" beads (activated by reaction with 1,6 - hexanediamine) chloromethylated polystyrene beads (unactivated), nylon (activated by reaction with 3-(dimethylamino)- propylamine), polyacrylamide (activated by diazotization followed by reaction with 1,6- hexanediamine), polyethylene terephthalate or ethylene-maleic anhydride copolymer (activated by reaction with 1,6-hexanediamine and cyclohexylcarbodiimide) or polyvinyl alcohol (activated by reaction with p-nitrobenzoyl chloride followed by reduction of the nitro group to amino with sodium dithionite).
GB3404073A 1973-07-17 1973-07-17 Immobilised pentacyclic triterpenes Expired GB1434044A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB3404073A GB1434044A (en) 1973-07-17 1973-07-17 Immobilised pentacyclic triterpenes
DE19742434385 DE2434385A1 (en) 1973-07-17 1974-07-17 FIXED TRITERPENS, METHOD FOR MANUFACTURING THEREOF AND MEDICINAL PREPARATIONS
JP49082662A JPS5031021A (en) 1973-07-17 1974-07-17

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3404073A GB1434044A (en) 1973-07-17 1973-07-17 Immobilised pentacyclic triterpenes

Publications (1)

Publication Number Publication Date
GB1434044A true GB1434044A (en) 1976-04-28

Family

ID=10360620

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3404073A Expired GB1434044A (en) 1973-07-17 1973-07-17 Immobilised pentacyclic triterpenes

Country Status (3)

Country Link
JP (1) JPS5031021A (en)
DE (1) DE2434385A1 (en)
GB (1) GB1434044A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101459070B1 (en) * 2013-12-09 2014-11-17 (주) 뉴메딕 Long lasting crosslinked polysaccharide gel formulation
CN108904447A (en) * 2018-08-15 2018-11-30 烟台大学 A kind of liver tumour targeted carrier material, micellar preparation and preparation method thereof
WO2024102456A1 (en) * 2022-11-09 2024-05-16 Cfd Research Corporation Compositions and methods for controlled release of therapeutic agents from articles

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07583B2 (en) * 1990-11-21 1995-01-11 北海道糖業株式会社 Water-soluble pentacyclic triterpene clathrate compound, method for producing the same, and food, beverage and oral composition using the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101459070B1 (en) * 2013-12-09 2014-11-17 (주) 뉴메딕 Long lasting crosslinked polysaccharide gel formulation
CN108904447A (en) * 2018-08-15 2018-11-30 烟台大学 A kind of liver tumour targeted carrier material, micellar preparation and preparation method thereof
CN108904447B (en) * 2018-08-15 2020-10-30 烟台大学 Liver tumor targeting carrier material, micelle preparation and preparation method thereof
WO2024102456A1 (en) * 2022-11-09 2024-05-16 Cfd Research Corporation Compositions and methods for controlled release of therapeutic agents from articles

Also Published As

Publication number Publication date
JPS5031021A (en) 1975-03-27
DE2434385A1 (en) 1975-02-06

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee