GB1434044A - Immobilised pentacyclic triterpenes - Google Patents
Immobilised pentacyclic triterpenesInfo
- Publication number
- GB1434044A GB1434044A GB3404073A GB3404073A GB1434044A GB 1434044 A GB1434044 A GB 1434044A GB 3404073 A GB3404073 A GB 3404073A GB 3404073 A GB3404073 A GB 3404073A GB 1434044 A GB1434044 A GB 1434044A
- Authority
- GB
- United Kingdom
- Prior art keywords
- activated
- reaction
- hexanediamine
- carrier
- oleanolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1434044 Resin-drug composites BIOREX LABORATORIES Ltd 2 July 1974 [17 July 1973] 34040/73 Headings C3A C3P C3R and C3U [Also in Divisions C2 and D1] The invention comprises pharmaceutically active pentacyclic triterpenes which have been immobilized by chemical attachment to a polymeric organic or inorganic carrier; and their preparation by reacting the triterpene with the carrier, either of which may be chemically activated as appropriate. Specified triterpenes are glycyrrhetinic, 3-dehydroglycyrrhetinic, oleanolic, 11-oxo-oleanolic and ursolic acids and the hemisuccinates, hemiglutarates and amides thereof, and hederagenin. The examples relate exclusively to glycyrrhetinic acid hemisuccinate which may be activated by reaction with isobutyl chloroformate. The carrier may be a polysaccharide, e.g. agarose, a cross-linked dextran, starch, cellulose or cellulose acetate, these being activated by successive reactions of the diol system thereof with cyanogen bromide and 1,6-hexanediamine (R = hexamethylene). The carrier may also be chloromethylated "hydrocarbon" beads (activated by reaction with 1,6 - hexanediamine) chloromethylated polystyrene beads (unactivated), nylon (activated by reaction with 3-(dimethylamino)- propylamine), polyacrylamide (activated by diazotization followed by reaction with 1,6- hexanediamine), polyethylene terephthalate or ethylene-maleic anhydride copolymer (activated by reaction with 1,6-hexanediamine and cyclohexylcarbodiimide) or polyvinyl alcohol (activated by reaction with p-nitrobenzoyl chloride followed by reduction of the nitro group to amino with sodium dithionite).
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3404073A GB1434044A (en) | 1973-07-17 | 1973-07-17 | Immobilised pentacyclic triterpenes |
DE19742434385 DE2434385A1 (en) | 1973-07-17 | 1974-07-17 | FIXED TRITERPENS, METHOD FOR MANUFACTURING THEREOF AND MEDICINAL PREPARATIONS |
JP49082662A JPS5031021A (en) | 1973-07-17 | 1974-07-17 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3404073A GB1434044A (en) | 1973-07-17 | 1973-07-17 | Immobilised pentacyclic triterpenes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1434044A true GB1434044A (en) | 1976-04-28 |
Family
ID=10360620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3404073A Expired GB1434044A (en) | 1973-07-17 | 1973-07-17 | Immobilised pentacyclic triterpenes |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS5031021A (en) |
DE (1) | DE2434385A1 (en) |
GB (1) | GB1434044A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101459070B1 (en) * | 2013-12-09 | 2014-11-17 | (주) 뉴메딕 | Long lasting crosslinked polysaccharide gel formulation |
CN108904447A (en) * | 2018-08-15 | 2018-11-30 | 烟台大学 | A kind of liver tumour targeted carrier material, micellar preparation and preparation method thereof |
WO2024102456A1 (en) * | 2022-11-09 | 2024-05-16 | Cfd Research Corporation | Compositions and methods for controlled release of therapeutic agents from articles |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07583B2 (en) * | 1990-11-21 | 1995-01-11 | 北海道糖業株式会社 | Water-soluble pentacyclic triterpene clathrate compound, method for producing the same, and food, beverage and oral composition using the same |
-
1973
- 1973-07-17 GB GB3404073A patent/GB1434044A/en not_active Expired
-
1974
- 1974-07-17 JP JP49082662A patent/JPS5031021A/ja active Pending
- 1974-07-17 DE DE19742434385 patent/DE2434385A1/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101459070B1 (en) * | 2013-12-09 | 2014-11-17 | (주) 뉴메딕 | Long lasting crosslinked polysaccharide gel formulation |
CN108904447A (en) * | 2018-08-15 | 2018-11-30 | 烟台大学 | A kind of liver tumour targeted carrier material, micellar preparation and preparation method thereof |
CN108904447B (en) * | 2018-08-15 | 2020-10-30 | 烟台大学 | Liver tumor targeting carrier material, micelle preparation and preparation method thereof |
WO2024102456A1 (en) * | 2022-11-09 | 2024-05-16 | Cfd Research Corporation | Compositions and methods for controlled release of therapeutic agents from articles |
Also Published As
Publication number | Publication date |
---|---|
JPS5031021A (en) | 1975-03-27 |
DE2434385A1 (en) | 1975-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |