GB1432904A - N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them - Google Patents

N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them

Info

Publication number
GB1432904A
GB1432904A GB3650274A GB3650274A GB1432904A GB 1432904 A GB1432904 A GB 1432904A GB 3650274 A GB3650274 A GB 3650274A GB 3650274 A GB3650274 A GB 3650274A GB 1432904 A GB1432904 A GB 1432904A
Authority
GB
United Kingdom
Prior art keywords
cyclohexyl
prepared
methylaminomethyl
benzamides
dibromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3650274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES73418443A external-priority patent/ES418443A1/en
Priority claimed from ES429200A external-priority patent/ES429200A1/en
Priority claimed from ES429207A external-priority patent/ES429207A1/en
Priority claimed from ES429203A external-priority patent/ES429203A1/en
Priority claimed from ES429201A external-priority patent/ES429201A1/en
Priority claimed from ES429206A external-priority patent/ES429206A1/en
Priority claimed from ES429204A external-priority patent/ES429204A1/en
Priority claimed from ES429205A external-priority patent/ES429205A1/en
Priority claimed from ES429199A external-priority patent/ES429199A1/en
Priority claimed from ES429202A external-priority patent/ES429202A1/en
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Publication of GB1432904A publication Critical patent/GB1432904A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1432904 N - [2 - (N - cyclohexyl - N - methylaminomethyl) - 4,6 - dibromo] - benzamides J URIACH Y CIA SA 20 Aug 1974 [24 Aug 1973 26 July 1974 (9)] 36502/74 Heading C2C Novel compounds I in which R<SP>1</SP> is C 1 -C 5 alkyl and R 2 is hydrogen or C 1 -C 5 acyl are prepared by reacting 2-(N<SP>1</SP>- cyclohexyl - N<SP>1</SP> - methyl - aminomethyl) - 4,6- dibromoaniline with a compound II Compounds II are prepared by chlorinating the corresponding acid and those acids in which R 2 is C 1 -C 5 acyl are prepared by acylation of the corresponding compound where R 2 is hydrogen. 3 - Ethoxy - 4 - hydroxybenzoic acid is prepared by oxidation of 3-ethoxy-4-hydroxybenzaldehyde. Compounds I have mucolytic activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally.
GB3650274A 1973-08-24 1974-08-20 N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them Expired GB1432904A (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
ES73418443A ES418443A1 (en) 1973-08-24 1973-08-24 Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429207A ES429207A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-butiroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429203A ES429203A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-isobutirexy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429201A ES429201A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-butyroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429200A ES429200A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429206A ES429206A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4-6-dibromo-phenyl) -3-metoxy-4-isobutiroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429204A ES429204A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4-6-dibromo-phenyl) -3-etoxy-4-valerianoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429205A ES429205A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-propioxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429199A ES429199A1 (en) 1974-07-26 1974-07-26 Process for the obtaining of N- (2- (n 'cyclohexyl-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-valerianoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
ES429202A ES429202A1 (en) 1974-07-26 1974-07-26 Procedure for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-propionoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
GB1432904A true GB1432904A (en) 1976-04-22

Family

ID=27579289

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3650274A Expired GB1432904A (en) 1973-08-24 1974-08-20 N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them

Country Status (3)

Country Link
DE (1) DE2440596C3 (en)
FR (1) FR2259595B1 (en)
GB (1) GB1432904A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11547123B2 (en) 2019-08-16 2023-01-10 The Folger Coffee Company Methods for reducing negative flavor attributes in coffee and compositions therefrom

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248702B (en) * 1990-06-06 1995-01-26 Yason Srl ANTITUSSIVE AGENT AND MUCOREGULATOR, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11547123B2 (en) 2019-08-16 2023-01-10 The Folger Coffee Company Methods for reducing negative flavor attributes in coffee and compositions therefrom

Also Published As

Publication number Publication date
FR2259595B1 (en) 1978-07-28
DE2440596C3 (en) 1980-01-03
DE2440596A1 (en) 1975-03-27
FR2259595A1 (en) 1975-08-29
DE2440596B2 (en) 1979-05-10

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Legal Events

Date Code Title Description
PS Patent sealed
PLE Entries relating assignments, transmissions, licences in the register of patents
PCNP Patent ceased through non-payment of renewal fee