GB1432904A - N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them - Google Patents
N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing themInfo
- Publication number
- GB1432904A GB1432904A GB3650274A GB3650274A GB1432904A GB 1432904 A GB1432904 A GB 1432904A GB 3650274 A GB3650274 A GB 3650274A GB 3650274 A GB3650274 A GB 3650274A GB 1432904 A GB1432904 A GB 1432904A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexyl
- prepared
- methylaminomethyl
- benzamides
- dibromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1432904 N - [2 - (N - cyclohexyl - N - methylaminomethyl) - 4,6 - dibromo] - benzamides J URIACH Y CIA SA 20 Aug 1974 [24 Aug 1973 26 July 1974 (9)] 36502/74 Heading C2C Novel compounds I in which R<SP>1</SP> is C 1 -C 5 alkyl and R 2 is hydrogen or C 1 -C 5 acyl are prepared by reacting 2-(N<SP>1</SP>- cyclohexyl - N<SP>1</SP> - methyl - aminomethyl) - 4,6- dibromoaniline with a compound II Compounds II are prepared by chlorinating the corresponding acid and those acids in which R 2 is C 1 -C 5 acyl are prepared by acylation of the corresponding compound where R 2 is hydrogen. 3 - Ethoxy - 4 - hydroxybenzoic acid is prepared by oxidation of 3-ethoxy-4-hydroxybenzaldehyde. Compounds I have mucolytic activity and form with a carrier a pharmaceutical composition which may be administered orally, parenterally or rectally.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES73418443A ES418443A1 (en) | 1973-08-24 | 1973-08-24 | Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429207A ES429207A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-butiroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429203A ES429203A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-isobutirexy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429201A ES429201A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-butyroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429200A ES429200A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429206A ES429206A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4-6-dibromo-phenyl) -3-metoxy-4-isobutiroxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429204A ES429204A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4-6-dibromo-phenyl) -3-etoxy-4-valerianoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429205A ES429205A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-etoxy-4-propioxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429199A ES429199A1 (en) | 1974-07-26 | 1974-07-26 | Process for the obtaining of N- (2- (n 'cyclohexyl-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-valerianoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
ES429202A ES429202A1 (en) | 1974-07-26 | 1974-07-26 | Procedure for the obtaining of N- (2- (n'-ciclohexil-n'-methyl-n'-methylen) -4,6-dibromo-phenyl) -3-metoxy-4-propionoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1432904A true GB1432904A (en) | 1976-04-22 |
Family
ID=27579289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3650274A Expired GB1432904A (en) | 1973-08-24 | 1974-08-20 | N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE2440596C3 (en) |
FR (1) | FR2259595B1 (en) |
GB (1) | GB1432904A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11547123B2 (en) | 2019-08-16 | 2023-01-10 | The Folger Coffee Company | Methods for reducing negative flavor attributes in coffee and compositions therefrom |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1248702B (en) * | 1990-06-06 | 1995-01-26 | Yason Srl | ANTITUSSIVE AGENT AND MUCOREGULATOR, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
-
1974
- 1974-08-20 GB GB3650274A patent/GB1432904A/en not_active Expired
- 1974-08-22 FR FR7428846A patent/FR2259595B1/fr not_active Expired
- 1974-08-23 DE DE2440596A patent/DE2440596C3/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11547123B2 (en) | 2019-08-16 | 2023-01-10 | The Folger Coffee Company | Methods for reducing negative flavor attributes in coffee and compositions therefrom |
Also Published As
Publication number | Publication date |
---|---|
FR2259595B1 (en) | 1978-07-28 |
DE2440596C3 (en) | 1980-01-03 |
DE2440596A1 (en) | 1975-03-27 |
FR2259595A1 (en) | 1975-08-29 |
DE2440596B2 (en) | 1979-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLE | Entries relating assignments, transmissions, licences in the register of patents | ||
PCNP | Patent ceased through non-payment of renewal fee |