GB1425295A - Alpha-aminoylidenephthalides and processes for their preparation - Google Patents

Alpha-aminoylidenephthalides and processes for their preparation

Info

Publication number
GB1425295A
GB1425295A GB305374A GB305374A GB1425295A GB 1425295 A GB1425295 A GB 1425295A GB 305374 A GB305374 A GB 305374A GB 305374 A GB305374 A GB 305374A GB 1425295 A GB1425295 A GB 1425295A
Authority
GB
United Kingdom
Prior art keywords
methyl
hydrogen
formula
aminoylidenephthalides
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB305374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LATVIISKY V NII KHIM REAKTIVOV
RIZH POLITEKHN I
Original Assignee
LATVIISKY V NII KHIM REAKTIVOV
RIZH POLITEKHN I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LATVIISKY V NII KHIM REAKTIVOV, RIZH POLITEKHN I filed Critical LATVIISKY V NII KHIM REAKTIVOV
Priority to GB305374A priority Critical patent/GB1425295A/en
Publication of GB1425295A publication Critical patent/GB1425295A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Abstract

1425295 α-Aminoylidenephthalides RIZHSKY ORDENA TRUDOVOGO KRASNOGO ZNAMENI POLITEKHNICHESKY INSTITUT and LATVIISKY FILIAL VSESOJUZNOGO ORDENA TRUDOVOGO KRASNOGO ZNAMENI NAUCHNO - ISSLEDOVATELSKY INSTITUT KHIMICHESKIKH REAKTIVOY I OSOBO CHISTYKH KHIMICHE SKIKH VESCHESTV 23 Jan 1974 03053/74 Heading C2C Novel α-aminoylidenephthalides of the formula wherein X is hydrogen or methoxy; R is methyl, phenyl, p-methoxyphenyl, p-chlorophenyl or p-bromophenyl; R<SP>1</SP> is hydrogen, methyl, ethyl or butyl; R<SP>11</SP> is hydrogen, methyl, ethyl, propyl, butyl, cyclohexyl, benzyl, phenyl, tolyl, p-methoxyphenyl, p-chlorophenyl or pbromophenyl; or R<SP>1</SP>R<SP>11</SP> is a radical of the formula -(CH 2 ) 2 -O-(CH 2 ) 2 -, -(CH 2 ) 4 - or -(CH 2 ) 5 -, are prepared by isomerizing a 2- amino-indanedione-1,3 of the formula in an organic solvent in the presence of a basic nucleophilic catalyst at the boiling temperature of the solvent. The catalyst is suitably sodium methoxide, ethoxide or phenoxide, a solution of potassium hydroxide in methanol or ethanol, piperidine or triethylamine. The novel compounds possess pharmaceutical properties.
GB305374A 1974-01-23 1974-01-23 Alpha-aminoylidenephthalides and processes for their preparation Expired GB1425295A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB305374A GB1425295A (en) 1974-01-23 1974-01-23 Alpha-aminoylidenephthalides and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB305374A GB1425295A (en) 1974-01-23 1974-01-23 Alpha-aminoylidenephthalides and processes for their preparation

Publications (1)

Publication Number Publication Date
GB1425295A true GB1425295A (en) 1976-02-18

Family

ID=9751094

Family Applications (1)

Application Number Title Priority Date Filing Date
GB305374A Expired GB1425295A (en) 1974-01-23 1974-01-23 Alpha-aminoylidenephthalides and processes for their preparation

Country Status (1)

Country Link
GB (1) GB1425295A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605738A (en) * 1982-11-18 1986-08-12 Shionogi & Co., Ltd. Production of 1-phthalidyl-5-fluorouracil derivatives
JP2014523416A (en) * 2011-06-16 2014-09-11 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー 1,3-Dioxoindene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof and pharmaceutical composition containing it as an antiviral active ingredient
US9790197B2 (en) 2012-12-14 2017-10-17 Katholieke Universiteit Leuven K.U. Leuven R & D Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
US9890133B2 (en) 2011-06-16 2018-02-13 Katholieke Universiteit Leuven K.U. Leuven R&D Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605738A (en) * 1982-11-18 1986-08-12 Shionogi & Co., Ltd. Production of 1-phthalidyl-5-fluorouracil derivatives
JP2014523416A (en) * 2011-06-16 2014-09-11 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー 1,3-Dioxoindene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof and pharmaceutical composition containing it as an antiviral active ingredient
JP2016185967A (en) * 2011-06-16 2016-10-27 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー 1,3-di-oxo-indene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof, and pharmaceutical composition containing the same as antiviral active ingredient
US9833423B2 (en) 2011-06-16 2017-12-05 Korea Research Institute Of Chemical Technology 1,3-Di-oxo-indene derivative, pharmaceutically acceptable salt or optical isomer thereof, preparation method thereof, and pharmaceutical composition containing same as an antiviral, active ingredient
US9890133B2 (en) 2011-06-16 2018-02-13 Katholieke Universiteit Leuven K.U. Leuven R&D Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
US9790197B2 (en) 2012-12-14 2017-10-17 Katholieke Universiteit Leuven K.U. Leuven R & D Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
US9951058B2 (en) 2012-12-14 2018-04-24 Katholieke Universiteit Leuven K.U. Leuven R & D Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee
PCNP Patent ceased through non-payment of renewal fee