GB1425081A - Antibiotics ws-3442a, b,c,d and e and n-acyl derivatives thereof - Google Patents
Antibiotics ws-3442a, b,c,d and e and n-acyl derivatives thereofInfo
- Publication number
- GB1425081A GB1425081A GB2930273A GB2930273A GB1425081A GB 1425081 A GB1425081 A GB 1425081A GB 2930273 A GB2930273 A GB 2930273A GB 2930273 A GB2930273 A GB 2930273A GB 1425081 A GB1425081 A GB 1425081A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotics
- medium
- antibiotic
- cephen
- oconh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/08—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin disubstituted in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1425081 Cephen compounds FUJISAWA PHARMACEUTICAL CO Ltd 20 June 1973 [27 June 1972 7 July 1972 20 July 1972 8 Feb 1973] 29302/73 Heading C2C Cephen antibiotics WS-3442 A, B, C, D and E having the general Formula (I): wherein (A) R is H and R<SP>1</SP> is H; (B) R is H and R<SP>1</SP> is -OCONH 2 ; (C) R is -OCH 3 and R<SP>1</SP> is -OCONH 2 ; (D) R is -OCH 3 and R<SP>1</SP> is H; and (E) R is H and R<SP>1</SP> is -OH, are prepared by aerobically cultivating Streptomyces wadayamensis (ATCC. 21948) or an antibiotic WS-3442- producing mutant thereof in an aqueous nutrient medium under aerated submerged conditions until substantial antibiotic activity is imparted to the medium, and then recovering the WS-3442 antibiotics from the medium. The WS-3442 antibiotics may be N-acylated to give novel cephem antibiotics of general Formula (II): wherein R is H or methoxy, R<SP>1</SP> is H, hydroxyl or caramoyloxy, and A is an acyl radical, by reacting one or more WS-3442 antibiotics, before or after separation from the fermentation medium, with an N-acylating agent. The compounds (II) have antibacterial activity and may be admixed with a pharmaceutical diluent or carrier to give antibiotic pharmaceutical compositions.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6462472A JPS552959B2 (en) | 1972-06-27 | 1972-06-27 | |
JP6856972A JPS5628520B2 (en) | 1972-07-07 | 1972-07-07 | |
JP7322372A JPS5443080B2 (en) | 1972-07-20 | 1972-07-20 | |
JP1630373A JPS5529680B2 (en) | 1973-02-08 | 1973-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1425081A true GB1425081A (en) | 1976-02-18 |
Family
ID=27456549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2930273A Expired GB1425081A (en) | 1972-06-27 | 1973-06-20 | Antibiotics ws-3442a, b,c,d and e and n-acyl derivatives thereof |
Country Status (5)
Country | Link |
---|---|
CH (2) | CH596227A5 (en) |
DE (1) | DE2332065C2 (en) |
FR (1) | FR2190420B1 (en) |
GB (1) | GB1425081A (en) |
NL (1) | NL7308948A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0095320A1 (en) * | 1982-05-21 | 1983-11-30 | Beecham Group Plc | A process for the preparation of beta-lactam compounds |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2400562T3 (en) | 2003-05-28 | 2013-04-10 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Cefem compound |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU35449B (en) * | 1968-07-01 | 1981-02-28 | Bristol Myers Co | Process for producing 7-amino-cephalosporanic acid |
-
1973
- 1973-06-20 GB GB2930273A patent/GB1425081A/en not_active Expired
- 1973-06-23 DE DE19732332065 patent/DE2332065C2/en not_active Expired
- 1973-06-26 FR FR7323350A patent/FR2190420B1/fr not_active Expired
- 1973-06-27 CH CH366677A patent/CH596227A5/xx not_active IP Right Cessation
- 1973-06-27 CH CH939273A patent/CH596308A5/xx not_active IP Right Cessation
- 1973-06-27 NL NL7308948A patent/NL7308948A/xx not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0095320A1 (en) * | 1982-05-21 | 1983-11-30 | Beecham Group Plc | A process for the preparation of beta-lactam compounds |
Also Published As
Publication number | Publication date |
---|---|
FR2190420B1 (en) | 1977-07-15 |
DE2332065A1 (en) | 1974-01-17 |
CH596308A5 (en) | 1978-03-15 |
FR2190420A1 (en) | 1974-02-01 |
NL7308948A (en) | 1974-01-02 |
DE2332065C2 (en) | 1984-11-22 |
CH596227A5 (en) | 1978-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |