GB1423273A - Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates - Google Patents
Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediatesInfo
- Publication number
- GB1423273A GB1423273A GB5392573A GB5392573A GB1423273A GB 1423273 A GB1423273 A GB 1423273A GB 5392573 A GB5392573 A GB 5392573A GB 5392573 A GB5392573 A GB 5392573A GB 1423273 A GB1423273 A GB 1423273A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- dihydroxy
- prostaglandins
- cis
- keto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 title 1
- 230000002906 microbiologic effect Effects 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000589564 Flavobacterium sp. Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011916 stereoselective reduction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/85—Flavobacterium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1423273 Prostaglandins G D SEARLE & CO 21 Nov 1973 [21 Nov 1972] 53925/73 Heading C2C cis-11,15-Dihydroxy prostaglandins are obtained by the stereoselective reduction of 11- hydroxy-15-keto prostaglandins by contacting, in an aqueous medium, the 11-hydroxy-15-keto prostaglandin with Flavobacterium sp. NRRL B-5641, or with enzymes derived therefrom, and isolating the required cis compound. The examples relate to the production of dl-cis- 11,15 - dihydroxy - 9 - oxoprosta - 8(12),13- dienoic acid, which can be resolved into individual enantiomers by known methods, and which is an intermediate in the production of d,l - 11α, 15(5) - dihydroxy - 9 - oxoprostanoic acid, a compound having hypotensive activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00308480A US3799841A (en) | 1972-11-21 | 1972-11-21 | Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1423273A true GB1423273A (en) | 1976-02-04 |
Family
ID=23194152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5392573A Expired GB1423273A (en) | 1972-11-21 | 1973-11-21 | Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US3799841A (en) |
| DE (1) | DE2357815A1 (en) |
| GB (1) | GB1423273A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1430191A (en) * | 1973-01-15 | 1976-03-31 | Ici Ltd | Reduction process for the preparation of prostaglandins and intermediates therefor |
| US3868306A (en) * | 1973-11-12 | 1975-02-25 | Wisconsin Alumni Res Found | Method for preparing 3(s or r)-hydroxy-1-iodo-1-trans-octene |
| DE2853637A1 (en) * | 1978-12-08 | 1980-06-12 | Schering Ag | MICROBIOLOGICAL REDUCTION OF 15-KETO-PROSTAGLANDIN INTERMEDIATE PRODUCTS |
-
1972
- 1972-11-21 US US00308480A patent/US3799841A/en not_active Expired - Lifetime
-
1973
- 1973-11-20 DE DE2357815A patent/DE2357815A1/en not_active Withdrawn
- 1973-11-21 GB GB5392573A patent/GB1423273A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3799841A (en) | 1974-03-26 |
| DE2357815A1 (en) | 1974-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |