GB1423021A - Methods and apparatuses for correcting coincidence count inaccuracies in a particle analyzer - Google Patents

Methods and apparatuses for correcting coincidence count inaccuracies in a particle analyzer

Info

Publication number
GB1423021A
GB1423021A GB1424273A GB1424273A GB1423021A GB 1423021 A GB1423021 A GB 1423021A GB 1424273 A GB1424273 A GB 1424273A GB 1424273 A GB1424273 A GB 1424273A GB 1423021 A GB1423021 A GB 1423021A
Authority
GB
United Kingdom
Prior art keywords
methods
count
computor
march
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1424273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Ltd
Coulter Electronics Inc
Original Assignee
Coulter Electronics Ltd
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/292,421 external-priority patent/US3949197A/en
Application filed by Coulter Electronics Ltd, Coulter Electronics Inc filed Critical Coulter Electronics Ltd
Publication of GB1423021A publication Critical patent/GB1423021A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N15/131—Details
    • G01N15/132—Circuits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G01N15/1427—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1024—Counting particles by non-optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1029—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1423021 Particle analysis COULTER ELECTRONICS Ltd 23 March 1973 [27 March 1972 26 Sept 1972] 14242/73 Heading G1N [Also in Division G4] The invention relates to the automatic STATISTICAL CORRECTION of the count from particle analysis apparatus, for errors due to coincidence of particles in the counting zone, by deriving TWO PARTICLE-PULSE COUNTS from the sample and entering them in a suitably programmed computor. The two counts may be obtained from (i) Two (or more) apertures having a known ratio of their "aperture critical volumes" Fig. 2 (not shown) (ii) two (or more) dilutions of the sample fed through a single aperture Fig. 3 (not shown) (iii) an artificial second count generated by delaying the pulse-train and adding it to the original train before counting Figs. 4 and 5 (not shown) (iv) a photo-electric sensor with a variable width light beam adjusted to provide two (or more) sensing zone volumes. Alternatively the apparatus could be programmed to determine a function used in the calculations and termed the CRITICAL VOLUME. The Specification derives the equations which the computor must solve for each of the four methods.
GB1424273A 1972-03-27 1973-03-23 Methods and apparatuses for correcting coincidence count inaccuracies in a particle analyzer Expired GB1423021A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23807972A 1972-03-27 1972-03-27
US05/292,421 US3949197A (en) 1972-09-26 1972-09-26 Methods and apparatuses for correcting coincidence count errors in a particle analyzer having a sensing zone through which the particles flow

Publications (1)

Publication Number Publication Date
GB1423021A true GB1423021A (en) 1976-01-28

Family

ID=26931325

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1424273A Expired GB1423021A (en) 1972-03-27 1973-03-23 Methods and apparatuses for correcting coincidence count inaccuracies in a particle analyzer

Country Status (11)

Country Link
JP (1) JPS5625611B2 (en)
AR (1) AR204610A1 (en)
BE (1) BE797228A (en)
CH (1) CH592303A5 (en)
DE (1) DE2314578C2 (en)
FR (1) FR2186135A5 (en)
GB (1) GB1423021A (en)
IL (1) IL41855A (en)
IT (1) IT1032020B (en)
NL (1) NL7304071A (en)
SE (1) SE391583B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412730A1 (en) * 2001-07-27 2004-04-28 Coulter International Corp. Particle count correction method and apparatus
CN114486689A (en) * 2022-04-15 2022-05-13 南京颐兰贝生物科技有限责任公司 Blood cell pulse counting error correction method and correction device

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2630780A1 (en) * 1975-07-09 1977-01-27 Coulter Electronics CORRECTION DEVICE FOR COINCIDENCE ERRORS IN PARTICLE EXAMINATION EQUIPMENT
JPS5338101A (en) * 1976-09-20 1978-04-07 Shimizu Construction Co Ltd Method of excavating inside of steel pipe pile
JPS5918511B2 (en) * 1981-04-13 1984-04-27 三井不動産建設株式会社 Cutting method using resonance

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412730A1 (en) * 2001-07-27 2004-04-28 Coulter International Corp. Particle count correction method and apparatus
EP1412730A4 (en) * 2001-07-27 2011-09-28 Beckman Coulter Inc Particle count correction method and apparatus
CN114486689A (en) * 2022-04-15 2022-05-13 南京颐兰贝生物科技有限责任公司 Blood cell pulse counting error correction method and correction device

Also Published As

Publication number Publication date
DE2314578A1 (en) 1973-10-11
AU5373673A (en) 1974-09-26
NL7304071A (en) 1973-10-01
BE797228A (en) 1973-07-16
AR204610A1 (en) 1976-02-20
DE2314578C2 (en) 1983-07-14
FR2186135A5 (en) 1974-01-04
SE391583B (en) 1977-02-21
IL41855A (en) 1977-05-31
CH592303A5 (en) 1977-10-31
JPS5625611B2 (en) 1981-06-13
JPS499282A (en) 1974-01-26
IL41855A0 (en) 1973-05-31
IT1032020B (en) 1979-05-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee