GB1415597A - Polymer entrapped or encapsulated enzyme compositions - Google Patents
Polymer entrapped or encapsulated enzyme compositionsInfo
- Publication number
- GB1415597A GB1415597A GB519773A GB519773A GB1415597A GB 1415597 A GB1415597 A GB 1415597A GB 519773 A GB519773 A GB 519773A GB 519773 A GB519773 A GB 519773A GB 1415597 A GB1415597 A GB 1415597A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- enzyme
- tube
- hydroxy lower
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000790 Enzymes Proteins 0.000 title abstract 7
- 102000004190 Enzymes Human genes 0.000 title abstract 7
- 229920000642 polymer Polymers 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- -1 alkyl methacrylates Chemical class 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000001124 body fluid Anatomy 0.000 abstract 2
- 239000010839 body fluid Substances 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 abstract 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 108010046334 Urease Proteins 0.000 abstract 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 abstract 1
- 125000005250 alkyl acrylate group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 229920000139 polyethylene terephthalate Polymers 0.000 abstract 1
- 239000005020 polyethylene terephthalate Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000003014 reinforcing effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
- B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polymerisation Methods In General (AREA)
Abstract
1415597 Reactions with absorbed enzymes NATIONAL PATENT DEVELOPMENT CORP 1 Feb 1973 [11 Feb 1972] 5197/73 Heading B1X [Also in Divisions C3 and G1] A process for subjecting a substrate e.g. blood or body fluid containing an enzymesusceptible material to the action of an enzyme comprises permitting the enzyme-susceptible material of the substrate to come into contact with the enzyme entrapped or encapsulated within a water-insoluble hydrophilic polymer of a monomer of the group consisting of hydroxy lower alkyl (i.e. C 1 -C 3 ) acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy lower alkyl methacrylates with or without a proportion of vinyl pyrrolidone, acrylamide, methacrylamide, N- lower alkyl acrylamide, N-lower alkyl methacrylamide, N-hydroxy lower alkyl acrylamide, and N-hydroxy lower alkyl methacrylamide. The water insoluble hydrophilic polymer may be in the form of a hollow tube having a relatively thin overall internal semipermeable membrane coating of a polymer as above, but enzyme free, the semi-permeable membrane being permeable to the enzyme-susceptible material but not to the enzyme. In Fig. 3 a tube 18, shown in crosssection, comprises a lumen 20, a urease containing polymer layer 22 containing a reinforcing sheathing of polyethylene terephthalate and, optionally, inner and outer coatings of water insoluble hydroxyethyl methacrylate polymer. When a solution of urea is forced through the lumen of the tube the solution diffuses to the enzyme entrapped tube and ammonia diffuses out of the outer surface of the tube thus enabling the purification of body fluids e.g. blood to eliminate urea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22548972A | 1972-02-11 | 1972-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1415597A true GB1415597A (en) | 1975-11-26 |
Family
ID=22845087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB519773A Expired GB1415597A (en) | 1972-02-11 | 1973-02-01 | Polymer entrapped or encapsulated enzyme compositions |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS4892446A (en) |
| AU (1) | AU469805B2 (en) |
| BE (1) | BE795316A (en) |
| CA (1) | CA1007586A (en) |
| DE (1) | DE2305320B2 (en) |
| ES (1) | ES411763A1 (en) |
| FR (2) | FR2171109B1 (en) |
| GB (1) | GB1415597A (en) |
| IL (1) | IL41450A (en) |
| IT (1) | IT987011B (en) |
| NL (1) | NL7301897A (en) |
| ZA (1) | ZA73696B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2490505A1 (en) * | 1980-09-23 | 1982-03-26 | California Inst Of Techn | APPARATUS AND METHOD FOR THE SEQUENTIAL EXECUTION OF CHEMICAL PROCESSES |
| EP0872729A1 (en) * | 1997-04-17 | 1998-10-21 | AVL Medical Instruments | Biosensor with a permeable polyvinylchloride outer membrane |
| EP2737916A1 (en) * | 2011-07-27 | 2014-06-04 | Asahi Kasei Medical Co., Ltd. | Hollow fiber membrane type blood purifier |
| EP4013886A4 (en) * | 2019-08-29 | 2023-08-09 | Shamsuddin, Abulkalam, Mohammed | Screening method, device, and kit for detecting mucosal carbohydrates and associated conditions |
| US11944641B2 (en) | 2020-04-03 | 2024-04-02 | Lpoxy Therapeutics, Inc. | Treatment of inflammatory bowel diseases through administration of enteric aerobization therapy |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925157A (en) * | 1972-07-12 | 1975-12-09 | Pfizer | Immobilized enzymes |
| CH593992A5 (en) * | 1972-12-23 | 1977-12-30 | Roehm Gmbh | |
| JPS5631951B2 (en) * | 1973-09-12 | 1981-07-24 | ||
| JPS5631949B2 (en) * | 1973-09-12 | 1981-07-24 | ||
| GB1486305A (en) * | 1973-09-12 | 1977-09-21 | Carborundum Co | Porous cartridges with fixed enzymes |
| JPS5219327B2 (en) * | 1973-11-15 | 1977-05-27 | ||
| JPS50123833A (en) * | 1974-03-18 | 1975-09-29 | ||
| JPS5126285A (en) * | 1974-08-30 | 1976-03-04 | Japan Atomic Energy Res Inst | Koso mataha kintaiofukunda soseibutsu no seizohoho |
| JPS5215885A (en) * | 1975-07-23 | 1977-02-05 | Japan Atom Energy Res Inst | Process for immobilizing enzymes or microbial cells |
| JPS5215887A (en) * | 1975-07-23 | 1977-02-05 | Japan Atom Energy Res Inst | Process for immobilizing enzymes and microbial cells |
| DE2633259C3 (en) * | 1975-07-23 | 1984-11-15 | Japan Atomic Energy Research Institute, Tokio/Tokyo | Method for immobilizing enzymes or enzyme-containing cells |
| JPS5235773A (en) * | 1975-09-17 | 1977-03-18 | Omron Tateisi Electronics Co | Reactive semipermeable membrane |
| JPS5247983A (en) * | 1975-10-09 | 1977-04-16 | Kyowa Yuka Kk | Method of immobilizing yeast or microbial cells |
| JPS5294487A (en) * | 1976-01-31 | 1977-08-09 | Japan Atom Energy Res Inst | Production of compositions containing enzyme or microbial cells |
| JPS5296791A (en) * | 1976-02-09 | 1977-08-13 | Japan Atom Energy Res Inst | Preparation of composition including enzymes or microorganisms |
| WO1989002916A1 (en) * | 1987-09-28 | 1989-04-06 | Novo-Nordisk A/S | Method for immobilizing lipase |
| US10357757B2 (en) * | 2014-06-24 | 2019-07-23 | Medtronic, Inc. | Stacked sorbent assembly |
| KR20240095216A (en) * | 2021-09-29 | 2024-06-25 | 엘폭시 세라퓨틱스 인코퍼레이티드 | Intestinal aeration therapy |
-
0
- BE BE795316D patent/BE795316A/en unknown
-
1973
- 1973-01-31 FR FR7303304A patent/FR2171109B1/fr not_active Expired
- 1973-01-31 ZA ZA730696A patent/ZA73696B/en unknown
- 1973-02-01 GB GB519773A patent/GB1415597A/en not_active Expired
- 1973-02-02 IL IL41450A patent/IL41450A/en unknown
- 1973-02-03 DE DE19732305320 patent/DE2305320B2/en not_active Ceased
- 1973-02-09 IT IT20222/73A patent/IT987011B/en active
- 1973-02-09 CA CA163,426A patent/CA1007586A/en not_active Expired
- 1973-02-09 NL NL7301897A patent/NL7301897A/xx unknown
- 1973-02-09 AU AU52037/73A patent/AU469805B2/en not_active Expired
- 1973-02-10 ES ES411763A patent/ES411763A1/en not_active Expired
- 1973-02-11 JP JP48017002A patent/JPS4892446A/ja active Pending
-
1974
- 1974-05-17 FR FR7417192A patent/FR2245668A1/fr not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2490505A1 (en) * | 1980-09-23 | 1982-03-26 | California Inst Of Techn | APPARATUS AND METHOD FOR THE SEQUENTIAL EXECUTION OF CHEMICAL PROCESSES |
| EP0872729A1 (en) * | 1997-04-17 | 1998-10-21 | AVL Medical Instruments | Biosensor with a permeable polyvinylchloride outer membrane |
| US6214185B1 (en) | 1997-04-17 | 2001-04-10 | Avl Medical Instruments | Sensor with PVC cover membrane |
| EP2737916A1 (en) * | 2011-07-27 | 2014-06-04 | Asahi Kasei Medical Co., Ltd. | Hollow fiber membrane type blood purifier |
| EP2737916A4 (en) * | 2011-07-27 | 2014-12-10 | Asahi Kasei Medical Co Ltd | Hollow fiber membrane type blood purifier |
| EP4013886A4 (en) * | 2019-08-29 | 2023-08-09 | Shamsuddin, Abulkalam, Mohammed | Screening method, device, and kit for detecting mucosal carbohydrates and associated conditions |
| US11944641B2 (en) | 2020-04-03 | 2024-04-02 | Lpoxy Therapeutics, Inc. | Treatment of inflammatory bowel diseases through administration of enteric aerobization therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2305320B2 (en) | 1976-09-30 |
| IL41450A0 (en) | 1973-04-30 |
| IT987011B (en) | 1975-02-20 |
| JPS4892446A (en) | 1973-11-30 |
| FR2171109A1 (en) | 1973-09-21 |
| CA1007586A (en) | 1977-03-29 |
| BE795316A (en) | 1973-05-29 |
| AU469805B2 (en) | 1976-02-26 |
| ZA73696B (en) | 1974-09-25 |
| FR2245668A1 (en) | 1975-04-25 |
| ES411763A1 (en) | 1976-01-01 |
| DE2305320A1 (en) | 1973-08-30 |
| FR2171109B1 (en) | 1979-03-02 |
| AU5203773A (en) | 1974-08-15 |
| IL41450A (en) | 1976-10-31 |
| NL7301897A (en) | 1973-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |