GB1395131A - Benzamide derivatives - Google Patents

Benzamide derivatives

Info

Publication number
GB1395131A
GB1395131A GB2820373A GB2820373A GB1395131A GB 1395131 A GB1395131 A GB 1395131A GB 2820373 A GB2820373 A GB 2820373A GB 2820373 A GB2820373 A GB 2820373A GB 1395131 A GB1395131 A GB 1395131A
Authority
GB
United Kingdom
Prior art keywords
methoxy
chlorobenzamide
reacting
amino
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2820373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOC DETUDES SCIENTIFIQUES ET INDUSTRIELLES DE
Original Assignee
SOC DETUDES SCIENTIFIQUES ET INDUSTRIELLES DE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOC DETUDES SCIENTIFIQUES ET INDUSTRIELLES DE filed Critical SOC DETUDES SCIENTIFIQUES ET INDUSTRIELLES DE
Publication of GB1395131A publication Critical patent/GB1395131A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1395131 N - [2 - (N,N - diethylamino)ethyl]- 2 - methoxy - 4 - amino - 5 - chlorobenzamide SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 13 June 1973 [20 June 1972] 28203/73 Heading C2C N - [2 - (N<SP>1</SP>,N<SP>1</SP> - diethylamino)ethyl] - 2- methoxy - 4 - amino - 5 - chlorobenzamide is prepared by reacting a C 1-3 alkyl 2-methoxy-4- acetamido-5-chlorobenzoate with ethanolamine, reacting the resulting novel N-(2-hydroxyethyl)- 2 - methoxy - 4 - acetamido - 5 - chlorobenzamide with thionyl chloride, followed by alkaline hydrolysis, and reacting the resulting novel N - (2 - chloroethyl) - 2 - methoxy - 4 - amino - 5- chlorobenzamide with diethylamine; and may subsequently be converted to its pharmaceutically acceptable mineral or organic acid addition salts or quaternary ammonium salts.
GB2820373A 1972-06-20 1973-06-13 Benzamide derivatives Expired GB1395131A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7222288A FR2277815A1 (en) 1972-06-20 1972-06-20 NEW PROCESS FOR THE PREPARATION OF N (DIETHYLAMINOETHYL) 2-METHOXY 4-AMINO 5-CHLOROBENZAMIDE

Publications (1)

Publication Number Publication Date
GB1395131A true GB1395131A (en) 1975-05-21

Family

ID=9100526

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2820373A Expired GB1395131A (en) 1972-06-20 1973-06-13 Benzamide derivatives

Country Status (26)

Country Link
JP (3) JPS5522468B2 (en)
KR (1) KR780000231B1 (en)
AT (1) AT350044B (en)
AU (1) AU468921B2 (en)
BE (1) BE801038A (en)
BG (3) BG22073A3 (en)
CA (1) CA1001170A (en)
CH (1) CH568277A5 (en)
CS (1) CS167389B2 (en)
DD (1) DD107441A5 (en)
DE (1) DE2330373A1 (en)
DK (1) DK131030B (en)
ES (1) ES415952A1 (en)
FI (1) FI56677C (en)
FR (1) FR2277815A1 (en)
GB (1) GB1395131A (en)
HU (1) HU166936B (en)
IE (1) IE37800B1 (en)
IL (1) IL42499A (en)
LU (1) LU67805A1 (en)
MC (1) MC1007A1 (en)
NO (1) NO135092C (en)
RO (1) RO64465A (en)
SE (5) SE402452B (en)
YU (1) YU36691B (en)
ZA (1) ZA734127B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523076A1 (en) * 1984-06-28 1986-01-09 Bristol-Myers Co., New York, N.Y. SUBSTITUTED BENZAMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
CN113698321A (en) * 2021-09-30 2021-11-26 内蒙古康普药业有限公司 New metoclopramide diamine impurity and application

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5881689U (en) * 1981-11-25 1983-06-02 富士電機冷機株式会社 Cup type vending machine
JPS59155682U (en) * 1983-04-05 1984-10-19 東芝機器株式会社 beverage vending machine
JPH02148390A (en) * 1988-11-30 1990-06-07 Fuji Electric Co Ltd Automatic vending machine for hot commodity
US10539725B2 (en) 2016-11-30 2020-01-21 Samsung Electronics Co., Ltd. Optical filter and camera module and electronic device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523076A1 (en) * 1984-06-28 1986-01-09 Bristol-Myers Co., New York, N.Y. SUBSTITUTED BENZAMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
CN113698321A (en) * 2021-09-30 2021-11-26 内蒙古康普药业有限公司 New metoclopramide diamine impurity and application

Also Published As

Publication number Publication date
JPS553341B2 (en) 1980-01-24
JPS553340B2 (en) 1980-01-24
DE2330373A1 (en) 1974-01-17
NO135092B (en) 1976-11-01
SE7602735L (en) 1976-02-27
NO135092C (en) 1977-02-09
ES415952A1 (en) 1976-02-01
FI56677B (en) 1979-11-30
CH568277A5 (en) 1975-10-31
SE421069B (en) 1981-11-23
BE801038A (en) 1973-12-18
ZA734127B (en) 1974-05-29
HU166936B (en) 1975-06-28
BG22073A3 (en) 1976-11-25
AU468921B2 (en) 1976-01-29
JPS4985039A (en) 1974-08-15
IL42499A (en) 1976-11-30
IL42499A0 (en) 1973-08-29
SE402452B (en) 1978-07-03
DK131030B (en) 1975-05-20
BG20570A3 (en) 1975-12-05
FI56677C (en) 1980-03-10
IE37800L (en) 1973-12-20
YU36691B (en) 1984-08-31
FR2277815B1 (en) 1978-10-20
CA1001170A (en) 1976-12-07
CS167389B2 (en) 1976-04-29
MC1007A1 (en) 1974-10-18
AT350044B (en) 1979-05-10
JPS5070334A (en) 1975-06-11
IE37800B1 (en) 1977-10-12
DD107441A5 (en) 1974-08-05
JPS5522468B2 (en) 1980-06-17
JPS5070333A (en) 1975-06-11
AU5699473A (en) 1974-12-19
YU160773A (en) 1982-06-18
SE7602736L (en) 1976-02-27
ATA531673A (en) 1978-10-15
DK131030C (en) 1975-10-20
SE7607357L (en) 1976-06-28
SE7607356L (en) 1976-06-28
KR780000231B1 (en) 1978-07-01
LU67805A1 (en) 1974-07-10
BG22074A3 (en) 1976-11-25
RO64465A (en) 1979-05-15
FR2277815A1 (en) 1976-02-06
SE421070B (en) 1981-11-23

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee