GB1393854A - Benzoic acid compounds and pharmaceutical compositions containing them - Google Patents

Benzoic acid compounds and pharmaceutical compositions containing them

Info

Publication number
GB1393854A
GB1393854A GB944373A GB944373A GB1393854A GB 1393854 A GB1393854 A GB 1393854A GB 944373 A GB944373 A GB 944373A GB 944373 A GB944373 A GB 944373A GB 1393854 A GB1393854 A GB 1393854A
Authority
GB
United Kingdom
Prior art keywords
methyl
chlorine
fluorine
benzoic acid
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB944373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to GB944373A priority Critical patent/GB1393854A/en
Publication of GB1393854A publication Critical patent/GB1393854A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups

Abstract

1393854 Pharmaceutical preparations containing benzoic acid derivatives PFIZER INC 26 Feb 1973 9443/73 Heading A5B [Also in Division C2] Pharmaceutical preparations suitable for treating atherosclerosis contain (I), (II) and/or (III) and/or salts thereof as active ingredient where X is fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl; R 1 is methyl, benzyl or substituted benzyl wherein the substituent is fluorine, chlorine, methyl, methoxy, trifluoromethyl or 3, 4-dimethoxy, or acylmethyl of the formula wherein R is alkyl containing from 1 to 4 carbon atoms or phenyl or substituted phenyl wherein the substituent is fluorine, chlorine, methyl, trifluoromethyl or methoxy; R 2 is methyl, 2-hydroxyethyl, allyl, methallyl, crotyl or acylmethyl of the formula wherein R is as defined above and; n is 0, 1 or 2; and R 3 is fluorine, chlorine, bromine or methyl. Administration is orally or parenterally.
GB944373A 1973-02-26 1973-02-26 Benzoic acid compounds and pharmaceutical compositions containing them Expired GB1393854A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB944373A GB1393854A (en) 1973-02-26 1973-02-26 Benzoic acid compounds and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB944373A GB1393854A (en) 1973-02-26 1973-02-26 Benzoic acid compounds and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1393854A true GB1393854A (en) 1975-05-14

Family

ID=9872058

Family Applications (1)

Application Number Title Priority Date Filing Date
GB944373A Expired GB1393854A (en) 1973-02-26 1973-02-26 Benzoic acid compounds and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB1393854A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020436A1 (en) * 1994-12-28 1996-07-04 Zeneca Limited Composition, compound and use
US5886044A (en) * 1995-02-17 1999-03-23 Smithkline Beecham Corporation IL-8 receptor antagonists
US6133319A (en) * 1996-06-27 2000-10-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
EP2266946A3 (en) * 2003-02-13 2012-12-12 Wellstat Therapeutics Corporation Compound For The Treatment Of Metabolic Disorders

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020436A1 (en) * 1994-12-28 1996-07-04 Zeneca Limited Composition, compound and use
US5925487A (en) * 1994-12-28 1999-07-20 Zeneca Limited Composition, compound and use
US5886044A (en) * 1995-02-17 1999-03-23 Smithkline Beecham Corporation IL-8 receptor antagonists
US6180675B1 (en) 1995-02-17 2001-01-30 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6133319A (en) * 1996-06-27 2000-10-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6271261B1 (en) 1996-06-27 2001-08-07 Smithkline Beecham Corporation IL-8 receptor antagonists
EP2266946A3 (en) * 2003-02-13 2012-12-12 Wellstat Therapeutics Corporation Compound For The Treatment Of Metabolic Disorders

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee