GB1387080A - Antibiotics and the preparation thereof - Google Patents
Antibiotics and the preparation thereofInfo
- Publication number
- GB1387080A GB1387080A GB3353673A GB3353673A GB1387080A GB 1387080 A GB1387080 A GB 1387080A GB 3353673 A GB3353673 A GB 3353673A GB 3353673 A GB3353673 A GB 3353673A GB 1387080 A GB1387080 A GB 1387080A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steffimycin
- characteristic
- max
- absorption spectrum
- alcoholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1387080 Steffimycin B UPJOHN CO 13 July 1973 [28 Aug 1972] 33536/73 Heading C2A Steffimycin B, a compound which: (a) is effective in inhibiting the growth of various Gram-positive bacteria; (b) has an optical rotation [a]<SP>25</SP> D +94 (c, 2, CHCl 3 ); (c) has a characteristic ultraviolet absorption spectrum as follows: In ethanol # max. at 234 mÁ (a=47À3) sh at 254 mÁ (a=36À9) sh at 274 mÁ (a=33À3) In 0À1N alcoholic KOH # max. at 233 mÁ (a=53À7) sh at 259 mÁ (a=45À0) In 0À1N alcoholic HCl # max. at 234 mÁ (a=46À7) sh at 254 mÁ (a=36À6) sh at 274 mÁ (a=33À0) (d) has a characteristic infra-red absorption spectrum in mineral oil mull (Fig. 1, not shown); (e) has the following elemental analyses: C, 58À68; H, 5À58; O, 35À74; (f) has a characteristic nuclear magnetic resonance spectrum (Fig. 2, not shown); (g) has a characteristic R f in the chromatographic system (Fig. 3, not shown), which differentiates it from steffimycin; and (h) has a molecular weight of 588 as determined by mass spectrometry, and non- toxic base addition salts thereof, are prepared by cultivating Streptomyces elgreteus sp. n., having the identifying characteristics of NRRL 5634, or Steffimycin B-producing mutants thereof, in an aqueous nutrient medium under aerobic conditions until substantial antibiotic activity is imparted to the medium by the production of Steffimycin B, and isolating the Stefflmycin B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28390872A | 1972-08-28 | 1972-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1387080A true GB1387080A (en) | 1975-03-12 |
Family
ID=23088082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3353673A Expired GB1387080A (en) | 1972-08-28 | 1973-07-13 | Antibiotics and the preparation thereof |
Country Status (6)
Country | Link |
---|---|
US (1) | US3794721A (en) |
JP (1) | JPS5641231B2 (en) |
DE (1) | DE2339136A1 (en) |
FR (1) | FR2197574B1 (en) |
GB (1) | GB1387080A (en) |
NL (1) | NL7311551A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2354978A1 (en) * | 1976-06-17 | 1978-01-13 | Saint Gobain | PROCESS FOR COATING A SUPPORT, IN PARTICULAR WINDOWS, WITH A THIN COAT OF METAL OXIDE, AND APPLICATIONS OF THIS PROCESS |
US4264726A (en) * | 1979-04-06 | 1981-04-28 | The Upjohn Company | Process for producing 10═dihydrosteffimycin and 10═dihydrosteffimycin B and microorganisms for producing same |
US4209611A (en) * | 1979-04-06 | 1980-06-24 | The Upjohn Company | Dihydrosteffimycin compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3309273A (en) * | 1965-12-29 | 1967-03-14 | Upjohn Co | Antibiotic steffisburgensimycin and method of producing |
-
1972
- 1972-08-28 US US00283908A patent/US3794721A/en not_active Expired - Lifetime
-
1973
- 1973-07-13 GB GB3353673A patent/GB1387080A/en not_active Expired
- 1973-07-31 JP JP8550773A patent/JPS5641231B2/ja not_active Expired
- 1973-08-02 DE DE2339136A patent/DE2339136A1/en not_active Withdrawn
- 1973-08-22 NL NL7311551A patent/NL7311551A/xx not_active Application Discontinuation
- 1973-08-27 FR FR7330897A patent/FR2197574B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS4942895A (en) | 1974-04-22 |
DE2339136A1 (en) | 1974-03-14 |
US3794721A (en) | 1974-02-26 |
FR2197574B1 (en) | 1977-09-09 |
FR2197574A1 (en) | 1974-03-29 |
NL7311551A (en) | 1974-03-04 |
JPS5641231B2 (en) | 1981-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |