GB1381339A - Process for preventing reversion during preparation of nucleus ester salts - Google Patents
Process for preventing reversion during preparation of nucleus ester saltsInfo
- Publication number
- GB1381339A GB1381339A GB5396872A GB5396872A GB1381339A GB 1381339 A GB1381339 A GB 1381339A GB 5396872 A GB5396872 A GB 5396872A GB 5396872 A GB5396872 A GB 5396872A GB 1381339 A GB1381339 A GB 1381339A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- ester
- alkyl
- imino
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1381339 Cephalosporins ELI LILLY & CO 22 Nov 1972 [30 Nov 1971 (2)] 53968/72 Heading C2C A process for preventing reversion of an imino halide of a 7-acylamidodesacetoxycephalosporinate ester of the formula where R is the residue of an acyl group and R 5 is the residue of an ester group, to a 7-acylamidodesacetoxycephalosporinate ester of the formula during treatment of the imino halide with an alcohol or thiol for the production of 7-aminodesacetoxycephalosporinate ester hydrohalides, comprises reacting the imino halide in an inert organic liquid diluent in the presence of hydrogen halide with alcohols or thiols of formulµ or wherein X represents 0 or 5; each of Y and Z is alkyl such that the alcohol or thiol has from 4 to 12 carbon atoms; or Y and Z are taken together with the carbon atom to which they are bonded to denote a cycloalkyl group having from 5 to 8 ring-forming carbon atoms; each of W and Z<SP>1</SP> is H or C 1 -C 2 alkyl, and each of R 1 and R 2 is H or a hydrocarbon moiety such that the 1,3-diol has from 3 to 15 carbon atoms; and each of R 3 and R 4 is H or alkyl such that the molecule has from 2 to 12 carbon atoms. The imino chloride of 4-nitrobenzyl 7-phenoxy-acetamido - 3 - methyl - 3 - cephem - 4 - carboxylate is prepared by reaction of 4-nitrobenzyl 7- phenoxyacetamido - 3 - methyl - 3 - cephem- 4-carboxylate with PCl 5 .
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US203398A US3868368A (en) | 1971-11-30 | 1971-11-30 | Process for preparing a 7-aminocephalosporin ester |
| US00203399A US3845043A (en) | 1971-11-30 | 1971-11-30 | Preventing reversion during preparation of nucleus ester salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1381339A true GB1381339A (en) | 1975-01-22 |
Family
ID=26898573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5396872A Expired GB1381339A (en) | 1971-11-30 | 1972-11-22 | Process for preventing reversion during preparation of nucleus ester salts |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5638595B2 (en) |
| AR (1) | AR192529A1 (en) |
| AT (1) | AT324551B (en) |
| BE (1) | BE791925A (en) |
| BG (2) | BG22402A3 (en) |
| CA (1) | CA985672A (en) |
| CH (1) | CH554372A (en) |
| CS (1) | CS188154B2 (en) |
| DD (1) | DD100958A5 (en) |
| DE (1) | DE2258079C3 (en) |
| ES (1) | ES409114A1 (en) |
| FR (1) | FR2163132A5 (en) |
| GB (1) | GB1381339A (en) |
| HU (1) | HU166394B (en) |
| IE (1) | IE36879B1 (en) |
| IL (1) | IL40897A (en) |
| NL (1) | NL173958C (en) |
| PH (1) | PH10235A (en) |
| PL (1) | PL89692B1 (en) |
| SE (1) | SE416400B (en) |
| YU (1) | YU36969B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT378774B (en) * | 1982-08-06 | 1985-09-25 | Biochemie Gmbh | METHOD FOR DEACYLATING PENICILLINES AND CEPHALOSPORINES |
| JPS59226670A (en) * | 1983-06-03 | 1984-12-19 | Jeol Ltd | Transistor inverter |
-
0
- BE BE791925D patent/BE791925A/en not_active IP Right Cessation
-
1972
- 1972-11-20 CA CA156,957A patent/CA985672A/en not_active Expired
- 1972-11-22 IE IE1621/72A patent/IE36879B1/en unknown
- 1972-11-22 IL IL40897A patent/IL40897A/en unknown
- 1972-11-22 GB GB5396872A patent/GB1381339A/en not_active Expired
- 1972-11-27 DE DE2258079A patent/DE2258079C3/en not_active Expired
- 1972-11-27 PH PH14119A patent/PH10235A/en unknown
- 1972-11-28 FR FR7242257A patent/FR2163132A5/fr not_active Expired
- 1972-11-28 NL NLAANVRAGE7216158,A patent/NL173958C/en not_active IP Right Cessation
- 1972-11-28 YU YU2970/72A patent/YU36969B/en unknown
- 1972-11-29 ES ES409114A patent/ES409114A1/en not_active Expired
- 1972-11-29 HU HUEI444A patent/HU166394B/hu unknown
- 1972-11-29 DD DD167181A patent/DD100958A5/xx unknown
- 1972-11-29 PL PL1972159178A patent/PL89692B1/en unknown
- 1972-11-29 SE SE7215532A patent/SE416400B/en unknown
- 1972-11-29 AT AT1017272A patent/AT324551B/en not_active IP Right Cessation
- 1972-11-29 CH CH1737772A patent/CH554372A/en not_active IP Right Cessation
- 1972-11-30 BG BG27793A patent/BG22402A3/xx unknown
- 1972-11-30 BG BG22014A patent/BG23008A3/xx unknown
- 1972-11-30 JP JP12028672A patent/JPS5638595B2/ja not_active Expired
- 1972-11-30 AR AR245396A patent/AR192529A1/en active
- 1972-11-30 CS CS728189A patent/CS188154B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7216158A (en) | 1973-06-04 |
| BG22402A3 (en) | 1977-02-20 |
| YU36969B (en) | 1984-08-31 |
| CH554372A (en) | 1974-09-30 |
| HU166394B (en) | 1975-03-28 |
| JPS5638595B2 (en) | 1981-09-08 |
| CS188154B2 (en) | 1979-02-28 |
| IL40897A0 (en) | 1973-01-30 |
| JPS4862792A (en) | 1973-09-01 |
| AR192529A1 (en) | 1973-02-21 |
| NL173958B (en) | 1983-11-01 |
| DE2258079C3 (en) | 1980-11-20 |
| PH10235A (en) | 1976-10-08 |
| NL173958C (en) | 1984-04-02 |
| DD100958A5 (en) | 1973-10-12 |
| BG23008A3 (en) | 1977-05-20 |
| IE36879L (en) | 1973-05-30 |
| PL89692B1 (en) | 1976-12-31 |
| BE791925A (en) | 1973-05-28 |
| ES409114A1 (en) | 1976-04-01 |
| IL40897A (en) | 1976-06-30 |
| YU297072A (en) | 1982-06-18 |
| DE2258079B2 (en) | 1980-03-27 |
| DE2258079A1 (en) | 1973-06-07 |
| AT324551B (en) | 1975-09-10 |
| CA985672A (en) | 1976-03-16 |
| IE36879B1 (en) | 1977-03-16 |
| FR2163132A5 (en) | 1973-07-20 |
| SE416400B (en) | 1980-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |