GB1379677A - Quinazoline derivative - Google Patents

Quinazoline derivative

Info

Publication number
GB1379677A
GB1379677A GB2906372A GB2906372A GB1379677A GB 1379677 A GB1379677 A GB 1379677A GB 2906372 A GB2906372 A GB 2906372A GB 2906372 A GB2906372 A GB 2906372A GB 1379677 A GB1379677 A GB 1379677A
Authority
GB
United Kingdom
Prior art keywords
methyl
isopropyl
quinazolinone
fluorophenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2906372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1379677A publication Critical patent/GB1379677A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1379677 1-Isopropyl-4-(4<SP>1</SP>-fluorophenyl)-7- methyl-2(1H)-quinazolinone SANDOZ Ltd 21 June 1972 [24 June 1971 18 Nov 1971] 29063/72 Heading C2C Novel 1 - isopropyl - 4 - (4<SP>1</SP> - fluorophenyl)- 7-methyl-2(1H)-quinazolinone is prepared (a) by reacting an alkyl (C 1-4 ) N-isopropyl-N-[2- (4<SP>1</SP> - fluorobenzoyl) - 5 - methyl - phenyl] carbamate with an ammonium salt of a C 1-4 aliphatic mono- or di-carboxylic acid or (b) by cyclizing 2 - N - isopropylamino - 4 - methyl- 4<SP>1</SP>-fluorobenzophenone with urea. Alkyl (C 1-4 ) N-isopropyl-N-[2-(4<SP>1</SP>-fluorobenzoyl) - 5 - methyl - phenyl]carbamates are prepared by reacting 2-N-isopropylamino-4- methyl-4<SP>1</SP>-fluorobenzophenone with a C 1-4 alkyl chloro- or bromo-formate. Pharmaceutical compositions having antiinflammatory and analgesic activity comprise, as active ingredient, 1-isopropyl-4-(4<SP>1</SP>-fluorophenyl - 7 - methyl - 2(1H) - quinazolinone, in association with a pharmaceutically acceptable diluent or carrier. Reference has been directed by the Comptroller to Specifications 1,248,430 and 1,181,570.
GB2906372A 1971-06-24 1972-06-21 Quinazoline derivative Expired GB1379677A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15646071A 1971-06-24 1971-06-24
US20014171A 1971-11-18 1971-11-18

Publications (1)

Publication Number Publication Date
GB1379677A true GB1379677A (en) 1975-01-08

Family

ID=26853204

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2906372A Expired GB1379677A (en) 1971-06-24 1972-06-21 Quinazoline derivative

Country Status (9)

Country Link
AU (1) AU4390572A (en)
BE (1) BE785283R (en)
CH (1) CH569722A5 (en)
DE (1) DE2230393C3 (en)
FR (1) FR2143345B2 (en)
GB (1) GB1379677A (en)
HK (1) HK23180A (en)
IE (1) IE36500B1 (en)
IL (1) IL39743A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453648A1 (en) * 1979-04-10 1980-11-07 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON A QUINAZOLINONE EXERCISING ANALGESIC ACTION AND A MYOTONOLYTIC AGENT

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1066039A4 (en) * 1998-03-02 2003-02-26 Cocensys Inc Substituted quinazolines and analogs and the use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453648A1 (en) * 1979-04-10 1980-11-07 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON A QUINAZOLINONE EXERCISING ANALGESIC ACTION AND A MYOTONOLYTIC AGENT
US4442084A (en) * 1979-04-10 1984-04-10 Sandoz Ltd. Analgesic and myotonolytic preparations

Also Published As

Publication number Publication date
BE785283R (en) 1972-12-22
DE2230393B2 (en) 1978-04-13
FR2143345A2 (en) 1973-02-02
IL39743A0 (en) 1972-08-30
AU4390672A (en) 1974-01-03
CH569722A5 (en) 1975-11-28
HK23180A (en) 1980-05-09
DE2230393C3 (en) 1978-12-07
IL39743A (en) 1976-04-30
AU4390572A (en) 1974-01-03
FR2143345B2 (en) 1977-03-25
IE36500B1 (en) 1976-11-24
DE2230393A1 (en) 1973-01-11
IE36500L (en) 1972-12-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee