GB1377379A - Production of 7-amino-3-methylcephem compounds - Google Patents

Production of 7-amino-3-methylcephem compounds

Info

Publication number
GB1377379A
GB1377379A GB5942471A GB5942471A GB1377379A GB 1377379 A GB1377379 A GB 1377379A GB 5942471 A GB5942471 A GB 5942471A GB 5942471 A GB5942471 A GB 5942471A GB 1377379 A GB1377379 A GB 1377379A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
ester
cephem
methyl
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5942471A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1377379A publication Critical patent/GB1377379A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/929—Fusarium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1377379 Deacylating cephalosporins TAKEDA YAKUHIN KOGYO KKC 21 Dec 1971 [25 Dec 1970] 59424/71 Heading C2C A method of producing 7-amino-3-methyl-3- 3 - cephem - 4 - carboxylic acid, or an ester thereof, comprises bringing a 7-acylamido-3- methyl-3-cephem-4-carboxylic acid, or an ester thereof, the acyl portion of the 7-acylamido group being phenylacetyl or phenoxyacetyl, into contact with a culture broth of a microorganism, or enzyme-containing processed matter thereof, the microorganism belonging to one of the genera Arthrinium, Aspergillus, Aureobasidium, Anthracobia, Ascotricha, Acremonium, Actinomucor, Alternaria, Aegerita, Beauveria, Botryotinia, Byssochlamys, Botyrosphaeria, Corynespora, Cunninghamella, Cylindrocarpon, Cylindrocladium, Colletotrichum, Cylindrocephalum, Cercospora, Ceratocystis, Cephalosporium, Cladosporium, Coniochaeta, Chaetomium, Chrysosporium, Cephaloascus, Diaporthe, Daedaleopsis, Dactylaria, Emericellopsis, Fusarium, Griphosphaeria, Gibberella, Glomerella, Isaria, Microascus, Neurospora, Pestalotiopsis, Pyrenophora, Pseudoplea, Papularia, Pleospora, Pellicularia, Rosellinia, Septoria, Sclerotium, Sartorya, Trichometasphaeria, Taphrina, Talaromyces, Verticillium, Nocardia, Streptomyces, Escherichia, Bacillus, Xanthomonas, Pseudomonas, Protaminobacter, Mycoplana, Aeromonas, Acetobacter, Rhodotorula, Cryptococcus, Nadeonia, Saccharomycodes and Saccharomyces, and being capable of producing 7 - amino - 3 - methyl - 3 - cephem- 4-carboxylic acid, or its ester, from the 7-acylamido - 3 - methyl - 3 - cephem - 4 - carboxylic acid, or its ester, by the hydrolysis in an aqueous medium of the acid amide linkage alone in case of the 4-carboxylic acid, or by the hydrolysis in an aqueous medium of the acid amide linkage alone or the hydrolyses in an aqueous medium of both the acid amide linkage and the carboxylic acid ester linkage in the case of the 4-carboxylic acid ester.
GB5942471A 1970-12-25 1971-12-21 Production of 7-amino-3-methylcephem compounds Expired GB1377379A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP45129648A JPS4948760B1 (en) 1970-12-25 1970-12-25

Publications (1)

Publication Number Publication Date
GB1377379A true GB1377379A (en) 1974-12-11

Family

ID=15014700

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5942471A Expired GB1377379A (en) 1970-12-25 1971-12-21 Production of 7-amino-3-methylcephem compounds

Country Status (13)

Country Link
US (1) US3749641A (en)
JP (1) JPS4948760B1 (en)
AT (1) AT320144B (en)
AU (1) AU467458B2 (en)
BE (1) BE777261A (en)
CA (1) CA1013692A (en)
CH (1) CH565186A5 (en)
DE (1) DE2163791C2 (en)
FR (1) FR2120839A5 (en)
GB (1) GB1377379A (en)
HU (1) HU166646B (en)
NL (1) NL175642C (en)
SE (1) SE402123B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5341232B2 (en) * 1972-06-17 1978-11-01
US4059573A (en) * 1973-08-01 1977-11-22 Glaxo Laboratories Limited Extraction of N-blocked amino acids from aqueous media
JPS5417032B2 (en) * 1974-01-23 1979-06-27
US4001600A (en) * 1975-06-02 1977-01-04 Watkins-Johnson Company Interconnecting circuit for ebs diodes and method
US3972774A (en) * 1975-07-28 1976-08-03 Eli Lilly And Company Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters
JPS52143289A (en) * 1976-05-24 1977-11-29 Meiji Seika Kaisha Ltd Production of 7-amino-cephem derivatives by filamentous fungi
US4230799A (en) * 1977-02-09 1980-10-28 Schering Corporation Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
US4316958A (en) * 1979-02-10 1982-02-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing optically active cephalosporin analogs
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
US4316955A (en) * 1980-11-10 1982-02-23 Eli Lilly And Company Enzymatic deesterification of cephalosporin methyl esters
US4618583A (en) * 1984-11-19 1986-10-21 E. R. Squibb & Sons, Inc. Method of preparing L-(+)-β-hydroxyisobutyric acid by fermentation
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
US5229274A (en) * 1989-06-27 1993-07-20 Merck & Co., Inc. Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme
GB9216759D0 (en) * 1992-08-07 1992-09-23 Finpael Spa Process for the production of 7-amino thiazolyl cephalosporins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD74282A (en) *
FR1357977A (en) * 1963-05-20 1964-04-10 Merck & Co Inc Process for the enzymatic production of 7-aminocephalosphalosporanic acid
US3284451A (en) * 1965-07-22 1966-11-08 Bristol Myers Co Activated esters of 7-amino-cephalosporanic acid
NL150798B (en) * 1967-08-07 1976-09-15 Koninklijke Gist Spiritus PROCESS FOR THE PREPARATION OF 7-AMINOCEPHALOSORANIC ACID AND ITS DERIVATIVES.
US3522250A (en) * 1968-10-15 1970-07-28 American Home Prod Derivatives of 7-aminocephalosporanic acid

Also Published As

Publication number Publication date
AU467458B2 (en) 1975-12-04
AT320144B (en) 1975-01-27
FR2120839A5 (en) 1972-08-18
NL175642C (en) 1984-12-03
DE2163791A1 (en) 1972-07-20
CH565186A5 (en) 1975-08-15
SE402123B (en) 1978-06-19
NL7117696A (en) 1972-06-27
HU166646B (en) 1975-04-28
AU3737171A (en) 1973-06-28
BE777261A (en) 1972-04-17
CA1013692A (en) 1977-07-12
JPS4948760B1 (en) 1974-12-23
US3749641A (en) 1973-07-31
NL175642B (en) 1984-07-02
DE2163791C2 (en) 1985-02-21

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Legal Events

Date Code Title Description
414F Notice of opposition given (sect. 14/1949)
414A Case decided by the comptroller ** specification amended (sect. 14/1949)
PS Patent sealed [section 19, patents act 1949]
SP Amendment (slips) printed
PE20 Patent expired after termination of 20 years