GB1369247A - Amines the preparation thereof and their use in pharmaceutical compositions - Google Patents
Amines the preparation thereof and their use in pharmaceutical compositionsInfo
- Publication number
- GB1369247A GB1369247A GB3652271A GB3652271A GB1369247A GB 1369247 A GB1369247 A GB 1369247A GB 3652271 A GB3652271 A GB 3652271A GB 3652271 A GB3652271 A GB 3652271A GB 1369247 A GB1369247 A GB 1369247A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- carbon atoms
- alkoxy
- hydroxyalkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1369247 Diamine and triamine derivatives PFIZER Inc 3 Aug 1971 [7 Aug 1970 24 May 1971] 36522/71 Heading C2C [Also in Division A5] The invention comprises novel therapeutic compounds (I) and the di-N-oxides, methonium iodides and non- toxic acid addition salts thereof wherein R 1 is alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms or R 2 is alkyl of from 6 to 20 carbon atoms, aralkyl or aryloxyalkyl of from 12 to 24 carbon atoms or as Formula II above, R‹ is alkoxy of from 1 to 18 carbon atoms; each of R<SP>1</SP> and R<SP>11</SP> is hydrogen, alkyl, or alkoxy of from 1 to 18 carbon atoms; or R<SP>1</SP> and R<SP>11</SP>; when taken together, are methylenedioxy; provided that the total number of carbon atoms in R‹, R<SP>1</SP> and R<SP>11</SP> is from 5 to 48; R 3 is hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, phenylcarbamoyloxy-(alkyl), #- carboxyalkanoyloxy-(alkyl), allyl, alkanoyl of from 1 to 6 carbon atoms, alkanoyloxy-(alkyl), carbo alkoxy alkyl, carboxy (alkyl), alkoxy (alkyl) or gem-di-(alkoxy) alkyl; R 4 is hydrogen, alkyl of from 1 to 8 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, carbo alkoxy alkyl, alkanoyloxy-(alkyl), carboxy-(alkyl), alkoxy- (alkyl), phenylcarbamoyloxy-(alkyl), #-carboxyalkanoyloxy-(alkyl), allyl, dihydroxyalkyl of from 3 to 8 carbon atoms or morpholinoethyl; R 3 and R 4 when taken together with the nitrogen to which they are attached are morpholino; X is straight chain alkylene of from 2 to 6 carbon atoms or X<SP>1</SP> is X, phenylenedimethylene or m is 0 or 1, with the provisos that only one of X and X<SP>1</SP> is and when X<SP>1</SP> is phenylenedimethylene, m is 0; and when X is alkylene, m is 1 and each of R 1 and R 2 is as Formula II. They are made by standard methods.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6219270A | 1970-08-07 | 1970-08-07 | |
US14654871A | 1971-05-24 | 1971-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1369247A true GB1369247A (en) | 1974-10-02 |
Family
ID=26741969
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3652271A Expired GB1369247A (en) | 1970-08-07 | 1971-08-03 | Amines the preparation thereof and their use in pharmaceutical compositions |
GB1725573A Expired GB1369248A (en) | 1970-08-07 | 1971-08-03 | Amides the preparation thereof and their use in pharmacjeutical compositions |
GB1725773A Expired GB1369250A (en) | 1970-08-07 | 1971-08-03 | Amines the preparation thereof and their use in pharmacejtical compositions |
GB1725673A Expired GB1369249A (en) | 1970-08-07 | 1971-08-03 | Amines the preparation thereof and their use in pharmaceutical compositions |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1725573A Expired GB1369248A (en) | 1970-08-07 | 1971-08-03 | Amides the preparation thereof and their use in pharmacjeutical compositions |
GB1725773A Expired GB1369250A (en) | 1970-08-07 | 1971-08-03 | Amines the preparation thereof and their use in pharmacejtical compositions |
GB1725673A Expired GB1369249A (en) | 1970-08-07 | 1971-08-03 | Amines the preparation thereof and their use in pharmaceutical compositions |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS5950646B1 (en) |
AR (1) | AR194346A1 (en) |
AU (1) | AU465751B2 (en) |
BE (1) | BE770966A (en) |
CA (1) | CA1001158A (en) |
CH (2) | CH586184A5 (en) |
DE (2) | DE2139545C2 (en) |
ES (2) | ES393965A1 (en) |
FR (2) | FR2102116B1 (en) |
GB (4) | GB1369247A (en) |
NL (1) | NL172615C (en) |
PH (1) | PH13755A (en) |
SE (3) | SE399701B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0008696A1 (en) * | 1978-08-30 | 1980-03-19 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same |
US4987130A (en) * | 1987-02-06 | 1991-01-22 | Takeda Chemical Industries, Ltd. | Substituted amine derivatives, their production and use |
US5763495A (en) * | 1996-09-30 | 1998-06-09 | Albemarle Corporation | Widely-bridged alcohol polyethoxylates and their use |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4166132A (en) * | 1977-08-18 | 1979-08-28 | Pfizer Inc. | Antiviral amine derivatives of glycerol and propanediols |
EP0018741A3 (en) * | 1979-05-08 | 1981-05-27 | Imperial Chemical Industries Plc | Long chain amine derivatives and process for their preparation |
FR2507083A1 (en) * | 1981-06-04 | 1982-12-10 | Pos Lab | AMINO-1 DODECYCLOXY-3-PROPANE COLLYRY COMPOSITION FOR THE TREATMENT OF CONJUNCTIVITIS AND KERATIVES |
US4480092A (en) * | 1982-02-19 | 1984-10-30 | The B. F. Goodrich Company | Alkylated polyalkylenepolyamines, substituted oxo-piperazinyl-triazines |
FI832935A (en) * | 1982-08-20 | 1984-02-21 | Midit | DERIVATIVES AV W-AMINOSYROR, DERAS FRAMSTAELLNING SAMT DESSA DERIVAT INNEHAOLLANDE BLANDNINGAR |
US4504484A (en) * | 1982-11-04 | 1985-03-12 | Chevron Research Company | Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use |
JP2756000B2 (en) * | 1989-08-25 | 1998-05-25 | 花王株式会社 | Tertiary amino alcohol and method for producing the same |
GB9118105D0 (en) * | 1991-08-22 | 1991-10-09 | Exxon Chemical Patents Inc | Compounds and fuel compositions |
DE4302860A1 (en) * | 1993-01-22 | 1994-08-04 | Chemie Linz Deutschland | N-Cyclic and N, N'dicyclic ureas |
AT400566B (en) * | 1993-01-22 | 1996-01-25 | Chemie Linz Gmbh | Use and process for the preparation of N-cyclic and N,N'- dicyclic ureas |
RU2445094C1 (en) * | 2010-10-05 | 2012-03-20 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Interferon-inducing agent for treating acute respiratory viral infections (arvd) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3355355A (en) * | 1965-02-05 | 1967-11-28 | Smith Kline French Lab | Antiviral cycloalkylamine compositions and method |
US3531489A (en) * | 1968-10-18 | 1970-09-29 | Richardson Merrell Inc | Bis-basic esters and thioesters of fluoranthene |
-
1971
- 1971-08-03 GB GB3652271A patent/GB1369247A/en not_active Expired
- 1971-08-03 GB GB1725573A patent/GB1369248A/en not_active Expired
- 1971-08-03 GB GB1725773A patent/GB1369250A/en not_active Expired
- 1971-08-03 GB GB1725673A patent/GB1369249A/en not_active Expired
- 1971-08-04 CA CA119,768A patent/CA1001158A/en not_active Expired
- 1971-08-04 AU AU32007/71A patent/AU465751B2/en not_active Expired
- 1971-08-05 BE BE770966A patent/BE770966A/en not_active IP Right Cessation
- 1971-08-06 DE DE19712139545 patent/DE2139545C2/en not_active Expired
- 1971-08-06 SE SE1010771A patent/SE399701B/en unknown
- 1971-08-06 DE DE19712167223 patent/DE2167223C2/en not_active Expired
- 1971-08-06 ES ES393965A patent/ES393965A1/en not_active Expired
- 1971-08-06 NL NL7110906A patent/NL172615C/en not_active IP Right Cessation
- 1971-08-06 FR FR7128941A patent/FR2102116B1/fr not_active Expired
- 1971-08-06 CH CH906074A patent/CH586184A5/xx not_active IP Right Cessation
- 1971-08-06 AR AR23726471A patent/AR194346A1/en active
- 1971-08-06 CH CH1165771A patent/CH568959A5/xx not_active IP Right Cessation
- 1971-08-07 JP JP5987871A patent/JPS5950646B1/ja active Pending
-
1973
- 1973-10-16 ES ES419681A patent/ES419681A1/en not_active Expired
-
1974
- 1974-11-26 FR FR7438755A patent/FR2258848B1/fr not_active Expired
-
1975
- 1975-02-06 SE SE7501332A patent/SE425658B/en not_active IP Right Cessation
- 1975-02-06 SE SE7501333A patent/SE425657B/en not_active IP Right Cessation
-
1976
- 1976-09-17 PH PH18920A patent/PH13755A/en unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0008696A1 (en) * | 1978-08-30 | 1980-03-19 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same |
US4987130A (en) * | 1987-02-06 | 1991-01-22 | Takeda Chemical Industries, Ltd. | Substituted amine derivatives, their production and use |
US5763495A (en) * | 1996-09-30 | 1998-06-09 | Albemarle Corporation | Widely-bridged alcohol polyethoxylates and their use |
US5902772A (en) * | 1996-09-30 | 1999-05-11 | Albemarle Corporation | Widely-bridged alcohol polyethoxylates and their use |
Also Published As
Publication number | Publication date |
---|---|
AU3200771A (en) | 1973-02-08 |
SE399701B (en) | 1978-02-27 |
AR194346A1 (en) | 1973-07-13 |
GB1369250A (en) | 1974-10-02 |
SE7501332L (en) | 1975-02-06 |
ES393965A1 (en) | 1974-07-01 |
BE770966A (en) | 1972-02-07 |
FR2258848B1 (en) | 1978-07-07 |
FR2102116A1 (en) | 1972-04-07 |
DE2167223C2 (en) | 1982-11-18 |
FR2102116B1 (en) | 1978-08-18 |
NL172615C (en) | 1983-10-03 |
NL172615B (en) | 1983-05-02 |
JPS5950646B1 (en) | 1984-12-10 |
AU465751B2 (en) | 1973-02-08 |
ES419681A1 (en) | 1976-05-16 |
GB1369249A (en) | 1974-10-02 |
CH568959A5 (en) | 1975-11-14 |
PH13755A (en) | 1980-09-17 |
SE425658B (en) | 1982-10-25 |
CH586184A5 (en) | 1977-03-31 |
NL7110906A (en) | 1972-02-09 |
FR2258848A1 (en) | 1975-08-22 |
GB1369248A (en) | 1974-10-02 |
SE425657B (en) | 1982-10-25 |
SE7501333L (en) | 1975-02-06 |
DE2139545A1 (en) | 1972-03-30 |
DE2139545C2 (en) | 1986-03-27 |
CA1001158A (en) | 1976-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |